Decision-making and role preferences for receiving individual pharmacogenomic research results among participants at a Ugandan HIV research institute
Abstract Little is known about how people living with HIV should be engaged in the decision-making process for returning individual pharmacogenomic research results. This study explored the role people living with HIV want to play in making decisions about whether and how individual results of pharm...
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BMC
2025-02-01
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| Series: | BMC Medical Ethics |
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| Online Access: | https://doi.org/10.1186/s12910-025-01181-w |
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| author | Sylvia Nabukenya Catriona Waitt Adelline Twimukye Brian Mushabe Barbara Castelnuovo Stella Zawedde-Muyanja Richard Muhindo David Kyaddondo Erisa S. Mwaka |
| author_facet | Sylvia Nabukenya Catriona Waitt Adelline Twimukye Brian Mushabe Barbara Castelnuovo Stella Zawedde-Muyanja Richard Muhindo David Kyaddondo Erisa S. Mwaka |
| author_sort | Sylvia Nabukenya |
| collection | DOAJ |
| description | Abstract Little is known about how people living with HIV should be engaged in the decision-making process for returning individual pharmacogenomic research results. This study explored the role people living with HIV want to play in making decisions about whether and how individual results of pharmacogenomic research should be presented to them. A convergent parallel mixed methods study was conducted, comprising a survey of 221 research participants and five deliberative focus group discussions with 30 purposively selected research participants. Most participants (122, 55.2%) preferred the collaborative role, 67 (30.3%) preferred the active role and 32 (14.5%) preferred the passive role. Factors that significantly influenced preference for an active role compared with a collaborative role were marital status (OR: 0.282, p = 0.013), research experience (OR: 4.37, p = 0.028), and religion (OR: 2.346, p = 0.041). The reasons proffered for the active role included prior experience with antiretroviral treatment and increased exposure to research activities. The reasons given for preferring the passive role included limited level of awareness about the interaction between patients’ genes and drugs, trust in researchers to make the right decision, and fear of making decisions with harmful implications. Overall, findings from our study show that participants want to be engaged in the decision-making process. Research teams ought to provide adequate and simple information about the pharmacogenomic research and implications of the results to support participants’ informed decisions. |
| format | Article |
| id | doaj-art-e11fbb28696c4916bc595817ec8f4ee7 |
| institution | Kabale University |
| issn | 1472-6939 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Ethics |
| spelling | doaj-art-e11fbb28696c4916bc595817ec8f4ee72025-02-09T12:53:24ZengBMCBMC Medical Ethics1472-69392025-02-0126111110.1186/s12910-025-01181-wDecision-making and role preferences for receiving individual pharmacogenomic research results among participants at a Ugandan HIV research instituteSylvia Nabukenya0Catriona Waitt1Adelline Twimukye2Brian Mushabe3Barbara Castelnuovo4Stella Zawedde-Muyanja5Richard Muhindo6David Kyaddondo7Erisa S. Mwaka8Makerere University College of Health SciencesInfectious Diseases InstituteInfectious Diseases InstituteMakerere University College of Health SciencesInfectious Diseases InstituteInfectious Diseases InstituteInfectious Diseases InstituteMakerere University College of Health SciencesMakerere University College of Health SciencesAbstract Little is known about how people living with HIV should be engaged in the decision-making process for returning individual pharmacogenomic research results. This study explored the role people living with HIV want to play in making decisions about whether and how individual results of pharmacogenomic research should be presented to them. A convergent parallel mixed methods study was conducted, comprising a survey of 221 research participants and five deliberative focus group discussions with 30 purposively selected research participants. Most participants (122, 55.2%) preferred the collaborative role, 67 (30.3%) preferred the active role and 32 (14.5%) preferred the passive role. Factors that significantly influenced preference for an active role compared with a collaborative role were marital status (OR: 0.282, p = 0.013), research experience (OR: 4.37, p = 0.028), and religion (OR: 2.346, p = 0.041). The reasons proffered for the active role included prior experience with antiretroviral treatment and increased exposure to research activities. The reasons given for preferring the passive role included limited level of awareness about the interaction between patients’ genes and drugs, trust in researchers to make the right decision, and fear of making decisions with harmful implications. Overall, findings from our study show that participants want to be engaged in the decision-making process. Research teams ought to provide adequate and simple information about the pharmacogenomic research and implications of the results to support participants’ informed decisions.https://doi.org/10.1186/s12910-025-01181-wDecision-makingRole preferencesPharmacogenomicsIndividual research resultsPeople living with HIV |
| spellingShingle | Sylvia Nabukenya Catriona Waitt Adelline Twimukye Brian Mushabe Barbara Castelnuovo Stella Zawedde-Muyanja Richard Muhindo David Kyaddondo Erisa S. Mwaka Decision-making and role preferences for receiving individual pharmacogenomic research results among participants at a Ugandan HIV research institute BMC Medical Ethics Decision-making Role preferences Pharmacogenomics Individual research results People living with HIV |
| title | Decision-making and role preferences for receiving individual pharmacogenomic research results among participants at a Ugandan HIV research institute |
| title_full | Decision-making and role preferences for receiving individual pharmacogenomic research results among participants at a Ugandan HIV research institute |
| title_fullStr | Decision-making and role preferences for receiving individual pharmacogenomic research results among participants at a Ugandan HIV research institute |
| title_full_unstemmed | Decision-making and role preferences for receiving individual pharmacogenomic research results among participants at a Ugandan HIV research institute |
| title_short | Decision-making and role preferences for receiving individual pharmacogenomic research results among participants at a Ugandan HIV research institute |
| title_sort | decision making and role preferences for receiving individual pharmacogenomic research results among participants at a ugandan hiv research institute |
| topic | Decision-making Role preferences Pharmacogenomics Individual research results People living with HIV |
| url | https://doi.org/10.1186/s12910-025-01181-w |
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