Five-year Survey of Bacterial Culture Isolates and Their Antibiogram in Pediatric Patients of Rural Tertiary Care Hospital of Central Gujarat
Aims and background: Most studies related to bacterial infections and their profiles in pediatric patients focus only on the pediatric intensive care unit (PICU) setup. Therefore, we undertook this study to review data on positive culture isolates in patients from all pediatric areas of our center,...
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| Format: | Article |
| Language: | English |
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Jaypee Brothers Medical Publisher
2024-07-01
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| Series: | Pediatric Infectious Disease |
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| Online Access: | https://www.pidjournal.com/doi/PID/pdf/10.5005/jp-journals-10081-1434 |
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| author | Krutika R Tandon Prachi Vani Rahul Tandon Nirav Thakar Swati Kamani Amit Kumar |
| author_facet | Krutika R Tandon Prachi Vani Rahul Tandon Nirav Thakar Swati Kamani Amit Kumar |
| author_sort | Krutika R Tandon |
| collection | DOAJ |
| description | Aims and background: Most studies related to bacterial infections and their profiles in pediatric patients focus only on the pediatric intensive care unit (PICU) setup. Therefore, we undertook this study to review data on positive culture isolates in patients from all pediatric areas of our center, excluding the neonatal unit, for their profiles and antibiotic sensitivity patterns.
Materials and methods: This was a retrospective study (5 years: 2017–2021) from hospital records including indoor patients (1 month to 18 years) from the PICU and pediatric ward. A total of 1,380 cultures (from any site) were sent, of which 706 were positive, excluding contaminations. Pertinent details were entered into Microsoft Excel and analyzed.
Results: A total of 706 positive isolates were found in 468 patients, and the mean [interquartile range (IQR)] age was 63 (18, 144) months. Males were 65%. Among positive culture isolates, 30.9, 24.8, 17.3, 16.1, 1.6, and 8.9% were from blood, pus, urine, endotracheal tube/tracheostomy tube (ET/TT), cerebrospinal fluid (CSF), and others, respectively. The median (IQR) hospital stay was 10 (4, 22) days. Total deaths were 17 (3.6%). Among positive culture isolates, gram-negative organisms in 205 (43.8%), <i>Staphylococcus aureus</i> was found in 135 (28.8%), <i>Salmonella typhi</i> in 53 (11.3%), and <i>Candida</i> in 24 (5.1%) cultures. Gram-negative organisms showed variable sensitivity to β-lactam/β-lactamase inhibitors and carbapenems. Among <i>S. aureus</i> isolates, 74 (39%) were oxacillin-sensitive. Almost all <i>Salmonella</i> were sensitive to ceftriaxone.
Conclusion: <i>S. aureus</i> was the single top isolate, with oxacillin resistance in almost two-thirds of isolates, whereas other gram-negative organisms were common nosocomial isolates with variable sensitivity to β-lactamase inhibitors and carbapenems.
Clinical significance: It includes recent data on microorganism profiles and their antibiograms from the western part of India. |
| format | Article |
| id | doaj-art-e1eec78a4a3f435281cd28dbe044e34d |
| institution | Kabale University |
| issn | 2582-4988 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Jaypee Brothers Medical Publisher |
| record_format | Article |
| series | Pediatric Infectious Disease |
| spelling | doaj-art-e1eec78a4a3f435281cd28dbe044e34d2025-02-07T11:21:56ZengJaypee Brothers Medical PublisherPediatric Infectious Disease2582-49882024-07-0163808710.5005/jp-journals-10081-14342Five-year Survey of Bacterial Culture Isolates and Their Antibiogram in Pediatric Patients of Rural Tertiary Care Hospital of Central GujaratKrutika R Tandon0https://orcid.org/0000-0001-6572-9917Prachi Vani1https://orcid.org/0000-0002-4556-8148Rahul Tandon2https://orcid.org/0000-0003-0127-5594Nirav Thakar3https://orcid.org/0000-0002-4899-7511Swati Kamani4https://orcid.org/0009-0007-2491-1588Amit Kumar5https://orcid.org/0000-0001-8950-4448Krutika R Tandon, Department of Pediatrics, Pramukhswami Medical College (PSMC), Bhaikaka University, Karamsad, Gujarat, India, Phone: +91 9879531972Department of Pediatrics, Bhalej General Hospital, Anand, Gujarat, IndiaDepartment of Pediatrics, Pramukhswami Medical College (PSMC), Bhaikaka University, Karamsad, Gujarat, IndiaDepartment of Medicine, Bhalej General Hospital, Anand, Gujarat, IndiaDepartment of Pediatrics, Pramukhswami Medical College (PSMC), Bhaikaka University, Karamsad, Gujarat, IndiaDepartment of Pediatrics, Pramukhswami Medical College (PSMC), Bhaikaka University, Karamsad, Gujarat, IndiaAims and background: Most studies related to bacterial infections and their profiles in pediatric patients focus only on the pediatric intensive care unit (PICU) setup. Therefore, we undertook this study to review data on positive culture isolates in patients from all pediatric areas of our center, excluding the neonatal unit, for their profiles and antibiotic sensitivity patterns. Materials and methods: This was a retrospective study (5 years: 2017–2021) from hospital records including indoor patients (1 month to 18 years) from the PICU and pediatric ward. A total of 1,380 cultures (from any site) were sent, of which 706 were positive, excluding contaminations. Pertinent details were entered into Microsoft Excel and analyzed. Results: A total of 706 positive isolates were found in 468 patients, and the mean [interquartile range (IQR)] age was 63 (18, 144) months. Males were 65%. Among positive culture isolates, 30.9, 24.8, 17.3, 16.1, 1.6, and 8.9% were from blood, pus, urine, endotracheal tube/tracheostomy tube (ET/TT), cerebrospinal fluid (CSF), and others, respectively. The median (IQR) hospital stay was 10 (4, 22) days. Total deaths were 17 (3.6%). Among positive culture isolates, gram-negative organisms in 205 (43.8%), <i>Staphylococcus aureus</i> was found in 135 (28.8%), <i>Salmonella typhi</i> in 53 (11.3%), and <i>Candida</i> in 24 (5.1%) cultures. Gram-negative organisms showed variable sensitivity to β-lactam/β-lactamase inhibitors and carbapenems. Among <i>S. aureus</i> isolates, 74 (39%) were oxacillin-sensitive. Almost all <i>Salmonella</i> were sensitive to ceftriaxone. Conclusion: <i>S. aureus</i> was the single top isolate, with oxacillin resistance in almost two-thirds of isolates, whereas other gram-negative organisms were common nosocomial isolates with variable sensitivity to β-lactamase inhibitors and carbapenems. Clinical significance: It includes recent data on microorganism profiles and their antibiograms from the western part of India.https://www.pidjournal.com/doi/PID/pdf/10.5005/jp-journals-10081-1434community-acquired infectiongram-negative microorganismnosocomial infection<i>salmonella</i><i>staphylococcus</i> |
| spellingShingle | Krutika R Tandon Prachi Vani Rahul Tandon Nirav Thakar Swati Kamani Amit Kumar Five-year Survey of Bacterial Culture Isolates and Their Antibiogram in Pediatric Patients of Rural Tertiary Care Hospital of Central Gujarat Pediatric Infectious Disease community-acquired infection gram-negative microorganism nosocomial infection <i>salmonella</i> <i>staphylococcus</i> |
| title | Five-year Survey of Bacterial Culture Isolates and Their Antibiogram in Pediatric Patients of Rural Tertiary Care Hospital of Central Gujarat |
| title_full | Five-year Survey of Bacterial Culture Isolates and Their Antibiogram in Pediatric Patients of Rural Tertiary Care Hospital of Central Gujarat |
| title_fullStr | Five-year Survey of Bacterial Culture Isolates and Their Antibiogram in Pediatric Patients of Rural Tertiary Care Hospital of Central Gujarat |
| title_full_unstemmed | Five-year Survey of Bacterial Culture Isolates and Their Antibiogram in Pediatric Patients of Rural Tertiary Care Hospital of Central Gujarat |
| title_short | Five-year Survey of Bacterial Culture Isolates and Their Antibiogram in Pediatric Patients of Rural Tertiary Care Hospital of Central Gujarat |
| title_sort | five year survey of bacterial culture isolates and their antibiogram in pediatric patients of rural tertiary care hospital of central gujarat |
| topic | community-acquired infection gram-negative microorganism nosocomial infection <i>salmonella</i> <i>staphylococcus</i> |
| url | https://www.pidjournal.com/doi/PID/pdf/10.5005/jp-journals-10081-1434 |
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