Nanotechnology-driven electrochemical neurotransmitter sensing as a fundamental approach towards improving diagnostics and therapeutics: A review
Neurotransmitters (NTs) are endogenous chemical messengers that have a wide range of key roles throughout the nervous system. It is an important signal medium of neural transfers and equally influence physiological conditions. While, abnormal levels are linked with psychotic, physical, and neurodege...
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| Format: | Article |
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Elsevier
2025-06-01
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| Series: | Sensors and Actuators Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666053925000128 |
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| author | Mehr Un Nisa Asim Yaqub Muhammad Hashim Khan Fatima Yaseen Shahaab Jilani Huma Ajab Noor S. Shah Abdulaziz Al-Anazi |
| author_facet | Mehr Un Nisa Asim Yaqub Muhammad Hashim Khan Fatima Yaseen Shahaab Jilani Huma Ajab Noor S. Shah Abdulaziz Al-Anazi |
| author_sort | Mehr Un Nisa |
| collection | DOAJ |
| description | Neurotransmitters (NTs) are endogenous chemical messengers that have a wide range of key roles throughout the nervous system. It is an important signal medium of neural transfers and equally influence physiological conditions. While, abnormal levels are linked with psychotic, physical, and neurodegenerative disorders such as ADHD, autism and tourette syndrome. Therefore, their accurate and sensitive detection is of great importance. Traditional methods of NTs detection are limited to complex sample processing, high cost, and real-time diagnostics. However, an electrochemical sensing has been extensively utilized in the past few years for NTs detection, which shows better sensitivity, selectivity, and capacity for operation in complicated biological environments, constitutes a promising approach. In this review, the most successful and favorable electrochemical sensors based on innovations in electrode materials and nanostructured surfaces having substantial improvement in the analytical performances and overcoming challenges followed by future prospects in NTs detection have been reported. This review additionally looks at the progress accomplished in biosensors for neurotransmitter evaluations in microfluidic lab-on-a-chip systems, smart wearable devices and other advanced technologies for the goal of real-time, portable diagnosis in neuroscience and clinics. These advances are paving the way for more effective applications of electrochemical sensing in neuroscience and clinical diagnostics. |
| format | Article |
| id | doaj-art-e2102e4fb0834e5f9dad40ef56d14017 |
| institution | Kabale University |
| issn | 2666-0539 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Sensors and Actuators Reports |
| spelling | doaj-art-e2102e4fb0834e5f9dad40ef56d140172025-02-06T05:12:46ZengElsevierSensors and Actuators Reports2666-05392025-06-019100292Nanotechnology-driven electrochemical neurotransmitter sensing as a fundamental approach towards improving diagnostics and therapeutics: A reviewMehr Un Nisa0Asim Yaqub1Muhammad Hashim Khan2Fatima Yaseen3Shahaab Jilani4Huma Ajab5Noor S. Shah6Abdulaziz Al-Anazi7Department of Chemistry, COMSATS University Islamabad, Abbottabad Campus, 22060, PakistanDepartment of Environmental Sciences, COMSATS University Islamabad, Abbottabad, 22060, PakistanDepartment of Chemistry, COMSATS University Islamabad, Abbottabad Campus, 22060, PakistanDepartment of Chemistry, COMSATS University Islamabad, Abbottabad Campus, 22060, PakistanDepartment of Chemistry, COMSATS University Islamabad, Abbottabad Campus, 22060, PakistanDepartment of Chemistry, COMSATS University Islamabad, Abbottabad Campus, 22060, Pakistan; Corresponding authors.Department of Chemistry, COMSATS University Islamabad, Abbottabad Campus, 22060, Pakistan; Corresponding authors.Department of Chemical Engineering, College of Engineering, King Saud University, P.O. Box 800, Riyadh 11421, Saudi Arabia; Corresponding authors.Neurotransmitters (NTs) are endogenous chemical messengers that have a wide range of key roles throughout the nervous system. It is an important signal medium of neural transfers and equally influence physiological conditions. While, abnormal levels are linked with psychotic, physical, and neurodegenerative disorders such as ADHD, autism and tourette syndrome. Therefore, their accurate and sensitive detection is of great importance. Traditional methods of NTs detection are limited to complex sample processing, high cost, and real-time diagnostics. However, an electrochemical sensing has been extensively utilized in the past few years for NTs detection, which shows better sensitivity, selectivity, and capacity for operation in complicated biological environments, constitutes a promising approach. In this review, the most successful and favorable electrochemical sensors based on innovations in electrode materials and nanostructured surfaces having substantial improvement in the analytical performances and overcoming challenges followed by future prospects in NTs detection have been reported. This review additionally looks at the progress accomplished in biosensors for neurotransmitter evaluations in microfluidic lab-on-a-chip systems, smart wearable devices and other advanced technologies for the goal of real-time, portable diagnosis in neuroscience and clinics. These advances are paving the way for more effective applications of electrochemical sensing in neuroscience and clinical diagnostics.http://www.sciencedirect.com/science/article/pii/S2666053925000128NanomaterialsCompositesElectrochemicalSensorsNeurotransmitterHealthcare |
| spellingShingle | Mehr Un Nisa Asim Yaqub Muhammad Hashim Khan Fatima Yaseen Shahaab Jilani Huma Ajab Noor S. Shah Abdulaziz Al-Anazi Nanotechnology-driven electrochemical neurotransmitter sensing as a fundamental approach towards improving diagnostics and therapeutics: A review Sensors and Actuators Reports Nanomaterials Composites Electrochemical Sensors Neurotransmitter Healthcare |
| title | Nanotechnology-driven electrochemical neurotransmitter sensing as a fundamental approach towards improving diagnostics and therapeutics: A review |
| title_full | Nanotechnology-driven electrochemical neurotransmitter sensing as a fundamental approach towards improving diagnostics and therapeutics: A review |
| title_fullStr | Nanotechnology-driven electrochemical neurotransmitter sensing as a fundamental approach towards improving diagnostics and therapeutics: A review |
| title_full_unstemmed | Nanotechnology-driven electrochemical neurotransmitter sensing as a fundamental approach towards improving diagnostics and therapeutics: A review |
| title_short | Nanotechnology-driven electrochemical neurotransmitter sensing as a fundamental approach towards improving diagnostics and therapeutics: A review |
| title_sort | nanotechnology driven electrochemical neurotransmitter sensing as a fundamental approach towards improving diagnostics and therapeutics a review |
| topic | Nanomaterials Composites Electrochemical Sensors Neurotransmitter Healthcare |
| url | http://www.sciencedirect.com/science/article/pii/S2666053925000128 |
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