A Soft Landing Approach for the Centrifugal Microgel Synthesis Process
Centrifugal microencapsulation has been shown to be a promising encapsulation technique, satisfying at the same time many requirements needed for biomedical applications (monodispersity, controlled size, spherical shape, sterile production environment) and allowing a high capsules production rate, u...
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Académie des sciences
2023-02-01
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| Series: | Comptes Rendus. Mécanique |
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| Online Access: | https://comptes-rendus.academie-sciences.fr/mecanique/articles/10.5802/crmeca.154/ |
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| author | Badalan, Matei Adisson, Lucie Boldron, Arthur Achard, Jean-Luc Ghigliotti, Giovanni Balarac, Guillaume Bottausci, Frédéric |
| author_facet | Badalan, Matei Adisson, Lucie Boldron, Arthur Achard, Jean-Luc Ghigliotti, Giovanni Balarac, Guillaume Bottausci, Frédéric |
| author_sort | Badalan, Matei |
| collection | DOAJ |
| description | Centrifugal microencapsulation has been shown to be a promising encapsulation technique, satisfying at the same time many requirements needed for biomedical applications (monodispersity, controlled size, spherical shape, sterile production environment) and allowing a high capsules production rate, using only conventional lab material. Another important advantage of this technology is the ability to process highly viscous biopolymer solutions. The usage of such solutions is desirable in multiple biomedical applications, because they yield capsules with improved mechanical properties (stiffness and yield strength) and with optimised porosity, which increases the immunoprotection in the case of biomaterial encapsulation applied to cell therapy and enhances a prolonged dissolution behaviour in the case of drug delivery applications. However, previous studies have shown that spherical capsules cannot be obtained using highly viscous solutions, and a capsule tail is always present when such solutions are used. This represents a significant limitation of this technology, since capsule shape regularity is an important requirement for various biomedical applications (e.g. cell therapy implants, drug delivery). In this article we propose and validate experimentally an adaptation of the centrifugal microencapsulation, based on the concept of “soft landing” [1]. This technique allows the production of ellipsoidal and spherical capsules using very viscous (typically up to several tens of $Pa.s$) biopolymer solutions. |
| format | Article |
| id | doaj-art-e2a7cfd1768c4ef19e971417b995a25f |
| institution | Kabale University |
| issn | 1873-7234 |
| language | English |
| publishDate | 2023-02-01 |
| publisher | Académie des sciences |
| record_format | Article |
| series | Comptes Rendus. Mécanique |
| spelling | doaj-art-e2a7cfd1768c4ef19e971417b995a25f2025-02-07T13:46:51ZengAcadémie des sciencesComptes Rendus. Mécanique1873-72342023-02-01351G18310210.5802/crmeca.15410.5802/crmeca.154A Soft Landing Approach for the Centrifugal Microgel Synthesis ProcessBadalan, Matei0Adisson, Lucie1Boldron, Arthur2Achard, Jean-Luc3Ghigliotti, Giovanni4Balarac, Guillaume5Bottausci, Frédéric6Univ. Grenoble Alpes, CEA, LETI, Technologies for Healthcare and biology division, Microfluidic Systems and Bioengineering Lab, 38000 Grenoble, France; Univ. Grenoble Alpes, CNRS, Grenoble INP, LEGI, 38000 Grenoble, FranceUniv. Grenoble Alpes, CEA, LETI, Technologies for Healthcare and biology division, Microfluidic Systems and Bioengineering Lab, 38000 Grenoble, FranceUniv. Grenoble Alpes, CEA, LETI, Technologies for Healthcare and biology division, Microfluidic Systems and Bioengineering Lab, 38000 Grenoble, FranceUniv. Grenoble Alpes, CEA, LETI, Technologies for Healthcare and biology division, Microfluidic Systems and Bioengineering Lab, 38000 Grenoble, France; Univ. Grenoble Alpes, CNRS, Grenoble INP, LEGI, 38000 Grenoble, FranceUniv. Grenoble Alpes, CNRS, Grenoble INP, LEGI, 38000 Grenoble, FranceUniv. Grenoble Alpes, CNRS, Grenoble INP, LEGI, 38000 Grenoble, FranceUniv. Grenoble Alpes, CEA, LETI, Technologies for Healthcare and biology division, Microfluidic Systems and Bioengineering Lab, 38000 Grenoble, FranceCentrifugal microencapsulation has been shown to be a promising encapsulation technique, satisfying at the same time many requirements needed for biomedical applications (monodispersity, controlled size, spherical shape, sterile production environment) and allowing a high capsules production rate, using only conventional lab material. Another important advantage of this technology is the ability to process highly viscous biopolymer solutions. The usage of such solutions is desirable in multiple biomedical applications, because they yield capsules with improved mechanical properties (stiffness and yield strength) and with optimised porosity, which increases the immunoprotection in the case of biomaterial encapsulation applied to cell therapy and enhances a prolonged dissolution behaviour in the case of drug delivery applications. However, previous studies have shown that spherical capsules cannot be obtained using highly viscous solutions, and a capsule tail is always present when such solutions are used. This represents a significant limitation of this technology, since capsule shape regularity is an important requirement for various biomedical applications (e.g. cell therapy implants, drug delivery). In this article we propose and validate experimentally an adaptation of the centrifugal microencapsulation, based on the concept of “soft landing” [1]. This technique allows the production of ellipsoidal and spherical capsules using very viscous (typically up to several tens of $Pa.s$) biopolymer solutions.https://comptes-rendus.academie-sciences.fr/mecanique/articles/10.5802/crmeca.154/Alginate microcapsulesCentrifugal microfluidicsMicroencapsulationShape optimisationHigh viscosity |
| spellingShingle | Badalan, Matei Adisson, Lucie Boldron, Arthur Achard, Jean-Luc Ghigliotti, Giovanni Balarac, Guillaume Bottausci, Frédéric A Soft Landing Approach for the Centrifugal Microgel Synthesis Process Comptes Rendus. Mécanique Alginate microcapsules Centrifugal microfluidics Microencapsulation Shape optimisation High viscosity |
| title | A Soft Landing Approach for the Centrifugal Microgel Synthesis Process |
| title_full | A Soft Landing Approach for the Centrifugal Microgel Synthesis Process |
| title_fullStr | A Soft Landing Approach for the Centrifugal Microgel Synthesis Process |
| title_full_unstemmed | A Soft Landing Approach for the Centrifugal Microgel Synthesis Process |
| title_short | A Soft Landing Approach for the Centrifugal Microgel Synthesis Process |
| title_sort | soft landing approach for the centrifugal microgel synthesis process |
| topic | Alginate microcapsules Centrifugal microfluidics Microencapsulation Shape optimisation High viscosity |
| url | https://comptes-rendus.academie-sciences.fr/mecanique/articles/10.5802/crmeca.154/ |
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