Association between pan-immune-inflammation value and coronary heart disease in elderly population: a cross-sectional study
BackgroundSystemic inflammation, immune and nutrition status are closely linked to the occurrence and development of coronary heart disease (CHD). Pan-immune-inflammation value (PIV) is a new method for evaluating systemic inflammation and immune status. Our objective is to explore the connection be...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1538643/full |
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| author | Ruicong Ma Jinyi Ren Xianmei Chen Xia Li Ying Zhao Yanchun Ding |
| author_facet | Ruicong Ma Jinyi Ren Xianmei Chen Xia Li Ying Zhao Yanchun Ding |
| author_sort | Ruicong Ma |
| collection | DOAJ |
| description | BackgroundSystemic inflammation, immune and nutrition status are closely linked to the occurrence and development of coronary heart disease (CHD). Pan-immune-inflammation value (PIV) is a new method for evaluating systemic inflammation and immune status. Our objective is to explore the connection between PIV and CHD especially in elderly people, as well as the diagnostic value of PIV combined with controlling nutritional status (COUNT) score for CHD.MethodsParticipants eligible for the study were sourced from NHANES data from 1999 to 2018. Logistic regression models were employed to evaluate the link between PIV and CHD. Additionally, restricted cubic spline was utilized to explore the correlations. Subgroup analysis was adopted in order to ensure the credibility of the results. The receiver operator characteristic (ROC) curve was used to explore the predictive value of PIV combined with COUNT score for CHD.Results41,713 individuals qualified for analysis. The individuals with CHD had higher levels of PIV. In the logistic regression model, PIV was positively related to CHD [Q4 vs. Q1, OR = 1.23 (1.03–1.48, P < 0.001)]. Restricted cubic spline indicated a positive non-linear relationship (P for overall <0.001, P for non-linear = 0.009). However, restricted cubic spline shows that this positive correlation is only significant in the elderly population aged 60 and above. Subgroup analysis shows that the relationship between PIV and CHD is more significant in the elderly population (P < 0.001). The ROC curve shows that PIV has better diagnostic value for CHD than other common inflammatory indicators. Furthermore, the combination of PIV and COUNT score is superior to PIV or COUNT score.ConclusionsA positive link between PIV and CHD, especially in the elderly. The combination of PIV and COUNT score has better diagnostic value for CHD. |
| format | Article |
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| institution | Kabale University |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-e335647a37f5427f85d10ee176173d6c2025-02-10T06:48:52ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-02-011210.3389/fcvm.2025.15386431538643Association between pan-immune-inflammation value and coronary heart disease in elderly population: a cross-sectional studyRuicong Ma0Jinyi Ren1Xianmei Chen2Xia Li3Ying Zhao4Yanchun Ding5Department of Cardiology, The Second Hospital of Dalian Medical University, Dalian, Liaoning, ChinaDepartment of Immunology, College of Basic Medical Science, Dalian Medical University, Dalian, Liaoning, ChinaDepartment of Immunology, College of Basic Medical Science, Dalian Medical University, Dalian, Liaoning, ChinaDepartment of Immunology, College of Basic Medical Science, Dalian Medical University, Dalian, Liaoning, ChinaMolecular Medical Laboratory, College of Basic Medical Science, Dalian Medical University, Dalian, ChinaDepartment of Cardiology, The Second Hospital of Dalian Medical University, Dalian, Liaoning, ChinaBackgroundSystemic inflammation, immune and nutrition status are closely linked to the occurrence and development of coronary heart disease (CHD). Pan-immune-inflammation value (PIV) is a new method for evaluating systemic inflammation and immune status. Our objective is to explore the connection between PIV and CHD especially in elderly people, as well as the diagnostic value of PIV combined with controlling nutritional status (COUNT) score for CHD.MethodsParticipants eligible for the study were sourced from NHANES data from 1999 to 2018. Logistic regression models were employed to evaluate the link between PIV and CHD. Additionally, restricted cubic spline was utilized to explore the correlations. Subgroup analysis was adopted in order to ensure the credibility of the results. The receiver operator characteristic (ROC) curve was used to explore the predictive value of PIV combined with COUNT score for CHD.Results41,713 individuals qualified for analysis. The individuals with CHD had higher levels of PIV. In the logistic regression model, PIV was positively related to CHD [Q4 vs. Q1, OR = 1.23 (1.03–1.48, P < 0.001)]. Restricted cubic spline indicated a positive non-linear relationship (P for overall <0.001, P for non-linear = 0.009). However, restricted cubic spline shows that this positive correlation is only significant in the elderly population aged 60 and above. Subgroup analysis shows that the relationship between PIV and CHD is more significant in the elderly population (P < 0.001). The ROC curve shows that PIV has better diagnostic value for CHD than other common inflammatory indicators. Furthermore, the combination of PIV and COUNT score is superior to PIV or COUNT score.ConclusionsA positive link between PIV and CHD, especially in the elderly. The combination of PIV and COUNT score has better diagnostic value for CHD.https://www.frontiersin.org/articles/10.3389/fcvm.2025.1538643/fullcoronary heart diseaseNHANESpan-immune-inflammation valuecontrolling nutritional status scoreelderly people |
| spellingShingle | Ruicong Ma Jinyi Ren Xianmei Chen Xia Li Ying Zhao Yanchun Ding Association between pan-immune-inflammation value and coronary heart disease in elderly population: a cross-sectional study Frontiers in Cardiovascular Medicine coronary heart disease NHANES pan-immune-inflammation value controlling nutritional status score elderly people |
| title | Association between pan-immune-inflammation value and coronary heart disease in elderly population: a cross-sectional study |
| title_full | Association between pan-immune-inflammation value and coronary heart disease in elderly population: a cross-sectional study |
| title_fullStr | Association between pan-immune-inflammation value and coronary heart disease in elderly population: a cross-sectional study |
| title_full_unstemmed | Association between pan-immune-inflammation value and coronary heart disease in elderly population: a cross-sectional study |
| title_short | Association between pan-immune-inflammation value and coronary heart disease in elderly population: a cross-sectional study |
| title_sort | association between pan immune inflammation value and coronary heart disease in elderly population a cross sectional study |
| topic | coronary heart disease NHANES pan-immune-inflammation value controlling nutritional status score elderly people |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1538643/full |
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