The Potential of Antibodies Against the Phosphatidylserine / Prothrombin Complex as a Biomarker in Antiphospholipid Syndrome
Introduction Antibodies against the phosphatidylserine/prothrombin complex aPS/PT are autoantibodies recognizing an epitope formed in the phosphatidylserine/prothrombin complex as a result of conformational changes resulting from the combination and not present in any of the initial components o...
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Kazimierz Wielki University
2025-02-01
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| Series: | Journal of Education, Health and Sport |
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| Online Access: | https://apcz.umk.pl/JEHS/article/view/57631 |
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| author | Piotr Pasek Witold Czyż Julia Kulbacka Julia Kacperczyk Marta Chuncia-Ileczko Michalina Wójcikiewicz Filip Arczewski Karol Dziedzic Maciej Wojszczyk Damian Zys Julia Ryniecka |
| author_facet | Piotr Pasek Witold Czyż Julia Kulbacka Julia Kacperczyk Marta Chuncia-Ileczko Michalina Wójcikiewicz Filip Arczewski Karol Dziedzic Maciej Wojszczyk Damian Zys Julia Ryniecka |
| author_sort | Piotr Pasek |
| collection | DOAJ |
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Introduction
Antibodies against the phosphatidylserine/prothrombin complex aPS/PT are autoantibodies recognizing an epitope formed in the phosphatidylserine/prothrombin complex as a result of conformational changes resulting from the combination and not present in any of the initial components of the complex. Its presence is predominantly observed in patients with thrombotic complications, particularly in those suffering from antiphospholipid syndrome (APS), systemic lupus erythematosus (SLE), and other connective tissue disorders. The new epitope is clinically relevant, as it plays a role in the mechanism and effects of autoantibody binding to phospholipids and their cofactors. Testing for aPS/PT, in conjunction with other APS markers, is recommended to assess the risk of thrombotic events.
Purpose
The object of this review is to assess whether aPS/PT complex serves as an effective diagnostic marker in the pathogenesis of complications associated with APS and other connective tissue disorders.
Material and methods
This review evaluates data from medical databases such as PubMed, NCBI or BMJ using the search term ‘aPS/PT’.
Conclusion
The presence of aPS/PT may be considered an independent risk factor for thrombosis. However, further research is needed to fully validate its clinical relevance in various clinical scenarios.
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| format | Article |
| id | doaj-art-e3934c1439cb414f877407be2d00061c |
| institution | Kabale University |
| issn | 2391-8306 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj-art-e3934c1439cb414f877407be2d00061c2025-02-06T08:18:20ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062025-02-017810.12775/JEHS.2025.78.57631The Potential of Antibodies Against the Phosphatidylserine / Prothrombin Complex as a Biomarker in Antiphospholipid SyndromePiotr Pasek0https://orcid.org/0009-0001-6218-9887Witold Czyżhttps://orcid.org/0009-0006-4442-9900Julia Kulbackahttps://orcid.org/0009-0005-1181-9104Julia Kacperczykhttps://orcid.org/0009-0007-6354-301XMarta Chuncia-Ileczkohttps://orcid.org/0009-0000-0913-9752Michalina Wójcikiewiczhttps://orcid.org/0009-0003-3671-1410Filip Arczewskihttps://orcid.org/0009-0008-5179-7255Karol Dziedzichttps://orcid.org/0009-0007-8317-723XMaciej Wojszczykhttps://orcid.org/0009-0002-8668-8821Damian Zyshttps://orcid.org/0009-0003-6578-6710Julia Rynieckahttps://orcid.org/0009-0000-5937-9498Copernicus Memorial Hospital, ul. Pabianicka 62, 93-513 Lodz, Poland Introduction Antibodies against the phosphatidylserine/prothrombin complex aPS/PT are autoantibodies recognizing an epitope formed in the phosphatidylserine/prothrombin complex as a result of conformational changes resulting from the combination and not present in any of the initial components of the complex. Its presence is predominantly observed in patients with thrombotic complications, particularly in those suffering from antiphospholipid syndrome (APS), systemic lupus erythematosus (SLE), and other connective tissue disorders. The new epitope is clinically relevant, as it plays a role in the mechanism and effects of autoantibody binding to phospholipids and their cofactors. Testing for aPS/PT, in conjunction with other APS markers, is recommended to assess the risk of thrombotic events. Purpose The object of this review is to assess whether aPS/PT complex serves as an effective diagnostic marker in the pathogenesis of complications associated with APS and other connective tissue disorders. Material and methods This review evaluates data from medical databases such as PubMed, NCBI or BMJ using the search term ‘aPS/PT’. Conclusion The presence of aPS/PT may be considered an independent risk factor for thrombosis. However, further research is needed to fully validate its clinical relevance in various clinical scenarios. https://apcz.umk.pl/JEHS/article/view/57631Antiphospholipid syndromeAnti-phosphatidylserine/prothrombin complex antibodiesSystemic Lupus ErythematosusLupus anticoagulantThrombosis |
| spellingShingle | Piotr Pasek Witold Czyż Julia Kulbacka Julia Kacperczyk Marta Chuncia-Ileczko Michalina Wójcikiewicz Filip Arczewski Karol Dziedzic Maciej Wojszczyk Damian Zys Julia Ryniecka The Potential of Antibodies Against the Phosphatidylserine / Prothrombin Complex as a Biomarker in Antiphospholipid Syndrome Journal of Education, Health and Sport Antiphospholipid syndrome Anti-phosphatidylserine/prothrombin complex antibodies Systemic Lupus Erythematosus Lupus anticoagulant Thrombosis |
| title | The Potential of Antibodies Against the Phosphatidylserine / Prothrombin Complex as a Biomarker in Antiphospholipid Syndrome |
| title_full | The Potential of Antibodies Against the Phosphatidylserine / Prothrombin Complex as a Biomarker in Antiphospholipid Syndrome |
| title_fullStr | The Potential of Antibodies Against the Phosphatidylserine / Prothrombin Complex as a Biomarker in Antiphospholipid Syndrome |
| title_full_unstemmed | The Potential of Antibodies Against the Phosphatidylserine / Prothrombin Complex as a Biomarker in Antiphospholipid Syndrome |
| title_short | The Potential of Antibodies Against the Phosphatidylserine / Prothrombin Complex as a Biomarker in Antiphospholipid Syndrome |
| title_sort | potential of antibodies against the phosphatidylserine prothrombin complex as a biomarker in antiphospholipid syndrome |
| topic | Antiphospholipid syndrome Anti-phosphatidylserine/prothrombin complex antibodies Systemic Lupus Erythematosus Lupus anticoagulant Thrombosis |
| url | https://apcz.umk.pl/JEHS/article/view/57631 |
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