L-shaped association between ankle-brachial index and coronary heart disease in Chinese adults with hypertension
Abstract Background Prior research has established that an ankle-brachial index (ABI) ≤ 0.9 is positively correlated with cardiovascular events, including coronary heart disease (CHD). The present study aimed to elucidate the dose–response relationship between ABI and CHD within a hypertensive popul...
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| Format: | Article |
| Language: | English |
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BMC
2025-02-01
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| Series: | European Journal of Medical Research |
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| Online Access: | https://doi.org/10.1186/s40001-025-02342-8 |
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| author | Wei Zhou Yumeng Shi Chao Yu Tao Wang Lingjuan Zhu Huihui Bao Xiaoshu Cheng |
| author_facet | Wei Zhou Yumeng Shi Chao Yu Tao Wang Lingjuan Zhu Huihui Bao Xiaoshu Cheng |
| author_sort | Wei Zhou |
| collection | DOAJ |
| description | Abstract Background Prior research has established that an ankle-brachial index (ABI) ≤ 0.9 is positively correlated with cardiovascular events, including coronary heart disease (CHD). The present study aimed to elucidate the dose–response relationship between ABI and CHD within a hypertensive population. Methods We conducted a cross-sectional analysis involving 10,900 hypertensive patients, with CHD as the primary outcome. A generalized additive model (GAM) and fitted smoothing curve were employed to assess linearity and delineate the dose–response association between ABI and CHD. Results The cohort had a mean (SD) age of 68.3 (9.25) years, with 5129 (47.06%) being male. CHD was present in 552 (5.06%) participants. The fully adjusted odds ratio (OR) for CHD associated with ABI levels was 0.75 (95%CI 0.33–1.71). An L-shaped relationship between ABI and CHD was identified, with an inflection point at 1.07. Below this threshold, ABI showed a negative correlation with CHD (OR: 0.27; 95%CI 0.08–0.84), whereas above it, the association was not significant (OR: 3.08; 95%CI 0.60–15.80). Conclusions In Chinese adults with hypertension, ABI exhibits a nonlinear, L-shaped association with CHD, with the inflection point at 1.07. |
| format | Article |
| id | doaj-art-e39f006dd3fd47fbae2bbb152fe9c897 |
| institution | Kabale University |
| issn | 2047-783X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj-art-e39f006dd3fd47fbae2bbb152fe9c8972025-02-09T12:26:40ZengBMCEuropean Journal of Medical Research2047-783X2025-02-013011810.1186/s40001-025-02342-8L-shaped association between ankle-brachial index and coronary heart disease in Chinese adults with hypertensionWei Zhou0Yumeng Shi1Chao Yu2Tao Wang3Lingjuan Zhu4Huihui Bao5Xiaoshu Cheng6Center for Prevention and Treatment of Cardiovascular Diseases, The Second Affiliated Hospital of Nanchang UniversitySchool of Public Health, The University of Hong KongCenter for Prevention and Treatment of Cardiovascular Diseases, The Second Affiliated Hospital of Nanchang UniversityCenter for Prevention and Treatment of Cardiovascular Diseases, The Second Affiliated Hospital of Nanchang UniversityCenter for Prevention and Treatment of Cardiovascular Diseases, The Second Affiliated Hospital of Nanchang UniversityCenter for Prevention and Treatment of Cardiovascular Diseases, The Second Affiliated Hospital of Nanchang UniversityCenter for Prevention and Treatment of Cardiovascular Diseases, The Second Affiliated Hospital of Nanchang UniversityAbstract Background Prior research has established that an ankle-brachial index (ABI) ≤ 0.9 is positively correlated with cardiovascular events, including coronary heart disease (CHD). The present study aimed to elucidate the dose–response relationship between ABI and CHD within a hypertensive population. Methods We conducted a cross-sectional analysis involving 10,900 hypertensive patients, with CHD as the primary outcome. A generalized additive model (GAM) and fitted smoothing curve were employed to assess linearity and delineate the dose–response association between ABI and CHD. Results The cohort had a mean (SD) age of 68.3 (9.25) years, with 5129 (47.06%) being male. CHD was present in 552 (5.06%) participants. The fully adjusted odds ratio (OR) for CHD associated with ABI levels was 0.75 (95%CI 0.33–1.71). An L-shaped relationship between ABI and CHD was identified, with an inflection point at 1.07. Below this threshold, ABI showed a negative correlation with CHD (OR: 0.27; 95%CI 0.08–0.84), whereas above it, the association was not significant (OR: 3.08; 95%CI 0.60–15.80). Conclusions In Chinese adults with hypertension, ABI exhibits a nonlinear, L-shaped association with CHD, with the inflection point at 1.07.https://doi.org/10.1186/s40001-025-02342-8Coronary heart diseaseAnkle-brachial indexHypertensionL-shaped curveStratified analysis |
| spellingShingle | Wei Zhou Yumeng Shi Chao Yu Tao Wang Lingjuan Zhu Huihui Bao Xiaoshu Cheng L-shaped association between ankle-brachial index and coronary heart disease in Chinese adults with hypertension European Journal of Medical Research Coronary heart disease Ankle-brachial index Hypertension L-shaped curve Stratified analysis |
| title | L-shaped association between ankle-brachial index and coronary heart disease in Chinese adults with hypertension |
| title_full | L-shaped association between ankle-brachial index and coronary heart disease in Chinese adults with hypertension |
| title_fullStr | L-shaped association between ankle-brachial index and coronary heart disease in Chinese adults with hypertension |
| title_full_unstemmed | L-shaped association between ankle-brachial index and coronary heart disease in Chinese adults with hypertension |
| title_short | L-shaped association between ankle-brachial index and coronary heart disease in Chinese adults with hypertension |
| title_sort | l shaped association between ankle brachial index and coronary heart disease in chinese adults with hypertension |
| topic | Coronary heart disease Ankle-brachial index Hypertension L-shaped curve Stratified analysis |
| url | https://doi.org/10.1186/s40001-025-02342-8 |
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