Immune Tolerance Regulation Is Critical to Immune Homeostasis
The body’s immune response plays a critical role in defending against external or foreign antigens while also preserving tolerance to self-antigens. This equilibrium, referred to as immune homeostasis, is paramount for overall health. The regulatory mechanisms governing the maintenance of this delic...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/jimr/5006201 |
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| _version_ | 1825199989808168960 |
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| author | Lei Han Tianxiang Wu Qin Zhang Anning Qi Xiaohui Zhou |
| author_facet | Lei Han Tianxiang Wu Qin Zhang Anning Qi Xiaohui Zhou |
| author_sort | Lei Han |
| collection | DOAJ |
| description | The body’s immune response plays a critical role in defending against external or foreign antigens while also preserving tolerance to self-antigens. This equilibrium, referred to as immune homeostasis, is paramount for overall health. The regulatory mechanisms governing the maintenance of this delicate immune balance are notably complex. It is currently accepted that immune tolerance is a dynamic outcome regulated by multiple factors, including central and peripheral mechanisms. Its induction or elimination plays a significant role in autoimmune diseases, organ transplantation, and cancer therapy, markedly impacting various major diseases in modern clinical practice. Overall, our current understanding of immune tolerance is still very limited. In this review article, we summarized the main mechanisms that have been known to mediate immune tolerance so far, including endogenous immune tolerance, adaptive immune tolerance, other immune tolerance mechanisms, and the homeostasis of immune tolerance, identified the key factors that regulate immune tolerance, and provided new clues for immune system recovery in many autoimmune diseases, organ transplantation, and tumor therapy. |
| format | Article |
| id | doaj-art-e43641a2df9f44c1add801cfe30e1f78 |
| institution | Kabale University |
| issn | 2314-7156 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-e43641a2df9f44c1add801cfe30e1f782025-02-08T00:00:06ZengWileyJournal of Immunology Research2314-71562025-01-01202510.1155/jimr/5006201Immune Tolerance Regulation Is Critical to Immune HomeostasisLei Han0Tianxiang Wu1Qin Zhang2Anning Qi3Xiaohui Zhou4Department of PharmacySchool of Basic Medicine and Clinical PharmacySchool of Basic Medicine and Clinical PharmacyMedical LaboratorySchool of Basic Medicine and Clinical PharmacyThe body’s immune response plays a critical role in defending against external or foreign antigens while also preserving tolerance to self-antigens. This equilibrium, referred to as immune homeostasis, is paramount for overall health. The regulatory mechanisms governing the maintenance of this delicate immune balance are notably complex. It is currently accepted that immune tolerance is a dynamic outcome regulated by multiple factors, including central and peripheral mechanisms. Its induction or elimination plays a significant role in autoimmune diseases, organ transplantation, and cancer therapy, markedly impacting various major diseases in modern clinical practice. Overall, our current understanding of immune tolerance is still very limited. In this review article, we summarized the main mechanisms that have been known to mediate immune tolerance so far, including endogenous immune tolerance, adaptive immune tolerance, other immune tolerance mechanisms, and the homeostasis of immune tolerance, identified the key factors that regulate immune tolerance, and provided new clues for immune system recovery in many autoimmune diseases, organ transplantation, and tumor therapy.http://dx.doi.org/10.1155/jimr/5006201 |
| spellingShingle | Lei Han Tianxiang Wu Qin Zhang Anning Qi Xiaohui Zhou Immune Tolerance Regulation Is Critical to Immune Homeostasis Journal of Immunology Research |
| title | Immune Tolerance Regulation Is Critical to Immune Homeostasis |
| title_full | Immune Tolerance Regulation Is Critical to Immune Homeostasis |
| title_fullStr | Immune Tolerance Regulation Is Critical to Immune Homeostasis |
| title_full_unstemmed | Immune Tolerance Regulation Is Critical to Immune Homeostasis |
| title_short | Immune Tolerance Regulation Is Critical to Immune Homeostasis |
| title_sort | immune tolerance regulation is critical to immune homeostasis |
| url | http://dx.doi.org/10.1155/jimr/5006201 |
| work_keys_str_mv | AT leihan immunetoleranceregulationiscriticaltoimmunehomeostasis AT tianxiangwu immunetoleranceregulationiscriticaltoimmunehomeostasis AT qinzhang immunetoleranceregulationiscriticaltoimmunehomeostasis AT anningqi immunetoleranceregulationiscriticaltoimmunehomeostasis AT xiaohuizhou immunetoleranceregulationiscriticaltoimmunehomeostasis |