Incidence and influencing factors of occupational pneumoconiosis: a systematic review and meta-analysis
Objectives To determine the incidence of pneumoconiosis worldwide and its influencing factors.Design Systematic review and meta-analysis.Setting Cohort studies on occupational pneumoconiosis.Participants PubMed, Embase, the Cochrane Library and Web of Science were searched until November 2021. Studi...
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BMJ Publishing Group
2023-03-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/13/3/e065114.full |
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| author | Xiao Yu Xinri Zhang Xuesen Su Xiaomei Kong |
| author_facet | Xiao Yu Xinri Zhang Xuesen Su Xiaomei Kong |
| author_sort | Xiao Yu |
| collection | DOAJ |
| description | Objectives To determine the incidence of pneumoconiosis worldwide and its influencing factors.Design Systematic review and meta-analysis.Setting Cohort studies on occupational pneumoconiosis.Participants PubMed, Embase, the Cochrane Library and Web of Science were searched until November 2021. Studies were selected for meta-analysis if they involved at least one variable investigated as an influencing factor for the incidence of pneumoconiosis and reported either the parameters and 95% CIs of the risk fit to the data, or sufficient information to allow for the calculation of those values.Primary outcome measures The pooled incidence of pneumoconiosis and risk ratio (RR) and 95% CIs of influencing factors.Results Our meta-analysis included 19 studies with a total of 335 424 participants, of whom 29 972 developed pneumoconiosis. The pooled incidence of pneumoconiosis was 0.093 (95% CI 0.085 to 0.135). We identified the following influencing factors: (1) male (RR 3.74; 95% CI 1.31 to 10.64; p=0.01), (2) smoking (RR 1.80; 95% CI 1.34 to 2.43; p=0.0001), (3) tunnelling category (RR 4.75; 95% CI 1.96 to 11.53; p<0.0001), (4) helping category (RR 0.07; 95% CI 0.13 to 0.16; p<0.0001), (5) age (the highest incidence occurs between the ages of 50 and 60), (6) duration of dust exposure (RR 4.59, 95% CI 2.41 to 8.74, p<0.01) and (7) cumulative total dust exposure (CTD) (RR 34.14, 95% CI 17.50 to 66.63, p<0.01). A dose–response analysis revealed a significant positive linear dose–response association between the risk of pneumoconiosis and duration of exposure and CTD (P-non-linearity=0.10, P-non-linearity=0.16; respectively). The Pearson correlation analysis revealed that silicosis incidence was highly correlated with cumulative silica exposure (r=0.794, p<0.001).Conclusion The incidence of pneumoconiosis in occupational workers was 0.093 and seven factors were found to be associated with the incidence, providing some insight into the prevention of pneumoconiosis.PROSPERO registration number CRD42022323233. |
| format | Article |
| id | doaj-art-e6a75a23d9a14e158656ed9824046226 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2023-03-01 |
| publisher | BMJ Publishing Group |
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| series | BMJ Open |
| spelling | doaj-art-e6a75a23d9a14e158656ed98240462262025-02-09T09:00:13ZengBMJ Publishing GroupBMJ Open2044-60552023-03-0113310.1136/bmjopen-2022-065114Incidence and influencing factors of occupational pneumoconiosis: a systematic review and meta-analysisXiao Yu0Xinri Zhang1Xuesen Su2Xiaomei Kong3The National Health Commission Key Laboratory of Pneumoconiosis (Shanxi, China) Project, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, ChinaThe National Health Commission Key Laboratory of Pneumoconiosis (Shanxi, China) Project, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, ChinaThe First College for Clinical Medicine, Shanxi Medical University, Taiyuan, Shanxi, ChinaThe National Health Commission Key Laboratory of Pneumoconiosis (Shanxi, China) Project, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, ChinaObjectives To determine the incidence of pneumoconiosis worldwide and its influencing factors.Design Systematic review and meta-analysis.Setting Cohort studies on occupational pneumoconiosis.Participants PubMed, Embase, the Cochrane Library and Web of Science were searched until November 2021. Studies were selected for meta-analysis if they involved at least one variable investigated as an influencing factor for the incidence of pneumoconiosis and reported either the parameters and 95% CIs of the risk fit to the data, or sufficient information to allow for the calculation of those values.Primary outcome measures The pooled incidence of pneumoconiosis and risk ratio (RR) and 95% CIs of influencing factors.Results Our meta-analysis included 19 studies with a total of 335 424 participants, of whom 29 972 developed pneumoconiosis. The pooled incidence of pneumoconiosis was 0.093 (95% CI 0.085 to 0.135). We identified the following influencing factors: (1) male (RR 3.74; 95% CI 1.31 to 10.64; p=0.01), (2) smoking (RR 1.80; 95% CI 1.34 to 2.43; p=0.0001), (3) tunnelling category (RR 4.75; 95% CI 1.96 to 11.53; p<0.0001), (4) helping category (RR 0.07; 95% CI 0.13 to 0.16; p<0.0001), (5) age (the highest incidence occurs between the ages of 50 and 60), (6) duration of dust exposure (RR 4.59, 95% CI 2.41 to 8.74, p<0.01) and (7) cumulative total dust exposure (CTD) (RR 34.14, 95% CI 17.50 to 66.63, p<0.01). A dose–response analysis revealed a significant positive linear dose–response association between the risk of pneumoconiosis and duration of exposure and CTD (P-non-linearity=0.10, P-non-linearity=0.16; respectively). The Pearson correlation analysis revealed that silicosis incidence was highly correlated with cumulative silica exposure (r=0.794, p<0.001).Conclusion The incidence of pneumoconiosis in occupational workers was 0.093 and seven factors were found to be associated with the incidence, providing some insight into the prevention of pneumoconiosis.PROSPERO registration number CRD42022323233.https://bmjopen.bmj.com/content/13/3/e065114.full |
| spellingShingle | Xiao Yu Xinri Zhang Xuesen Su Xiaomei Kong Incidence and influencing factors of occupational pneumoconiosis: a systematic review and meta-analysis BMJ Open |
| title | Incidence and influencing factors of occupational pneumoconiosis: a systematic review and meta-analysis |
| title_full | Incidence and influencing factors of occupational pneumoconiosis: a systematic review and meta-analysis |
| title_fullStr | Incidence and influencing factors of occupational pneumoconiosis: a systematic review and meta-analysis |
| title_full_unstemmed | Incidence and influencing factors of occupational pneumoconiosis: a systematic review and meta-analysis |
| title_short | Incidence and influencing factors of occupational pneumoconiosis: a systematic review and meta-analysis |
| title_sort | incidence and influencing factors of occupational pneumoconiosis a systematic review and meta analysis |
| url | https://bmjopen.bmj.com/content/13/3/e065114.full |
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