Mouse colorectal cancer organoids: Lessons from syngeneic and orthotopic transplantation systems
Colorectal cancer (CRC) organoids provide more accurate and tissue-relevant models compared to conventional two-dimensional cultured cell cultures. Mouse CRC organoids, in particular, offer unique advantages over their human counterparts, as they can be transplanted into immunocompetent mice. These...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | European Journal of Cell Biology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0171933525000032 |
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| _version_ | 1825206987249418240 |
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| author | Yu Muta Yuki Nakanishi |
| author_facet | Yu Muta Yuki Nakanishi |
| author_sort | Yu Muta |
| collection | DOAJ |
| description | Colorectal cancer (CRC) organoids provide more accurate and tissue-relevant models compared to conventional two-dimensional cultured cell cultures. Mouse CRC organoids, in particular, offer unique advantages over their human counterparts, as they can be transplanted into immunocompetent mice. These syngeneic transplantation models create a robust system for studying cancer biology in the immunocompetent tumor microenvironment (TME). This article discusses the development and applications of these organoid systems, emphasizing their capacity to faithfully recapitulate in vivo tumor progression, metastasis, and the immune landscape. |
| format | Article |
| id | doaj-art-e6df3490eee349509e6638251fb9a39a |
| institution | Kabale University |
| issn | 0171-9335 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | European Journal of Cell Biology |
| spelling | doaj-art-e6df3490eee349509e6638251fb9a39a2025-02-07T04:46:38ZengElsevierEuropean Journal of Cell Biology0171-93352025-06-011042151478Mouse colorectal cancer organoids: Lessons from syngeneic and orthotopic transplantation systemsYu Muta0Yuki Nakanishi1Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, JapanCorresponding author.; Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, JapanColorectal cancer (CRC) organoids provide more accurate and tissue-relevant models compared to conventional two-dimensional cultured cell cultures. Mouse CRC organoids, in particular, offer unique advantages over their human counterparts, as they can be transplanted into immunocompetent mice. These syngeneic transplantation models create a robust system for studying cancer biology in the immunocompetent tumor microenvironment (TME). This article discusses the development and applications of these organoid systems, emphasizing their capacity to faithfully recapitulate in vivo tumor progression, metastasis, and the immune landscape.http://www.sciencedirect.com/science/article/pii/S0171933525000032Colorectal cancerCancer organoidsOrthotopic transplantationSyngeneic transplantationTumor microenvironmentTumor immunity |
| spellingShingle | Yu Muta Yuki Nakanishi Mouse colorectal cancer organoids: Lessons from syngeneic and orthotopic transplantation systems European Journal of Cell Biology Colorectal cancer Cancer organoids Orthotopic transplantation Syngeneic transplantation Tumor microenvironment Tumor immunity |
| title | Mouse colorectal cancer organoids: Lessons from syngeneic and orthotopic transplantation systems |
| title_full | Mouse colorectal cancer organoids: Lessons from syngeneic and orthotopic transplantation systems |
| title_fullStr | Mouse colorectal cancer organoids: Lessons from syngeneic and orthotopic transplantation systems |
| title_full_unstemmed | Mouse colorectal cancer organoids: Lessons from syngeneic and orthotopic transplantation systems |
| title_short | Mouse colorectal cancer organoids: Lessons from syngeneic and orthotopic transplantation systems |
| title_sort | mouse colorectal cancer organoids lessons from syngeneic and orthotopic transplantation systems |
| topic | Colorectal cancer Cancer organoids Orthotopic transplantation Syngeneic transplantation Tumor microenvironment Tumor immunity |
| url | http://www.sciencedirect.com/science/article/pii/S0171933525000032 |
| work_keys_str_mv | AT yumuta mousecolorectalcancerorganoidslessonsfromsyngeneicandorthotopictransplantationsystems AT yukinakanishi mousecolorectalcancerorganoidslessonsfromsyngeneicandorthotopictransplantationsystems |