U-shaped association between TC/HDL-C ratio and osteoporosis risk in older adults
Abstract This study aimed to evaluate the association between the total cholesterol to high-density lipoprotein cholesterol (TC/HDL-C) ratio and the risk of osteoporosis in older adults. A cross-sectional analysis was conducted using data from 7,465 individuals aged 60 and above from the 2005–2020 N...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-02-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-89537-5 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823862527071617024 |
|---|---|
| author | Chuanwei Zhao Xiaochun Zhang Xu Zhang Bo Zhao Yane Yang Mu Lin Wenli Qiao Zeyao Hu Haijie Yang |
| author_facet | Chuanwei Zhao Xiaochun Zhang Xu Zhang Bo Zhao Yane Yang Mu Lin Wenli Qiao Zeyao Hu Haijie Yang |
| author_sort | Chuanwei Zhao |
| collection | DOAJ |
| description | Abstract This study aimed to evaluate the association between the total cholesterol to high-density lipoprotein cholesterol (TC/HDL-C) ratio and the risk of osteoporosis in older adults. A cross-sectional analysis was conducted using data from 7,465 individuals aged 60 and above from the 2005–2020 National Health and Nutrition Examination Survey (NHANES). The TC/HDL-C ratio was calculated and divided into quartiles. Osteoporosis was defined by self-reported physician diagnosis or dual-energy x-ray absorptiometry (DXA) measurements. Multivariable logistic regression models assessed the association between the TC/HDL-C ratio and osteoporosis prevalence. Restricted cubic splines were used to explore non-linear associations and threshold effects. Among the participants, 1,608 had osteoporosis. A higher TC/HDL-C ratio was inversely associated with osteoporosis (OR: 0.92, 95% CI: 0.86–0.99, p = 0.02). The analysis revealed a U-shaped association (p for nonlinearity = 0.005) with a threshold at 4.66. Below this threshold, the TC/HDL-C ratio was negatively associated with osteoporosis (OR: 0.83, 95% CI: 0.72–0.94, p = 0.010), while no significant association was observed above the threshold. In sex-specific analyses, a U-shaped relationship was found in women, with a threshold at 4.35 (p for nonlinearity = 0.0016), but no significant association was found in men. The TC/HDL-C ratio demonstrates a U-shaped association with osteoporosis risk in older adults, particularly in women. Further longitudinal studies are required to validate these findings and determine optimal lipid management strategies for osteoporosis prevention. |
| format | Article |
| id | doaj-art-e73ee7a6d53d44d9984d26709ecef136 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-e73ee7a6d53d44d9984d26709ecef1362025-02-09T12:31:12ZengNature PortfolioScientific Reports2045-23222025-02-0115111110.1038/s41598-025-89537-5U-shaped association between TC/HDL-C ratio and osteoporosis risk in older adultsChuanwei Zhao0Xiaochun Zhang1Xu Zhang2Bo Zhao3Yane Yang4Mu Lin5Wenli Qiao6Zeyao Hu7Haijie Yang8Department of Cardiology, The Second People’s Hospital of BaoshanDepartment of Cardiology, The Second People’s Hospital of BaoshanDepartment of Cardiology, The Second People’s Hospital of BaoshanDepartment of Cardiology, The Second People’s Hospital of BaoshanDepartment of Cardiology, The Second People’s Hospital of BaoshanDepartment of Cardiology, The Second People’s Hospital of BaoshanDepartment of Cardiology, The Second People’s Hospital of BaoshanDepartment of Cardiology, The Second People’s Hospital of BaoshanDepartment of Cardiology, The Second People’s Hospital of BaoshanAbstract This study aimed to evaluate the association between the total cholesterol to high-density lipoprotein cholesterol (TC/HDL-C) ratio and the risk of osteoporosis in older adults. A cross-sectional analysis was conducted using data from 7,465 individuals aged 60 and above from the 2005–2020 National Health and Nutrition Examination Survey (NHANES). The TC/HDL-C ratio was calculated and divided into quartiles. Osteoporosis was defined by self-reported physician diagnosis or dual-energy x-ray absorptiometry (DXA) measurements. Multivariable logistic regression models assessed the association between the TC/HDL-C ratio and osteoporosis prevalence. Restricted cubic splines were used to explore non-linear associations and threshold effects. Among the participants, 1,608 had osteoporosis. A higher TC/HDL-C ratio was inversely associated with osteoporosis (OR: 0.92, 95% CI: 0.86–0.99, p = 0.02). The analysis revealed a U-shaped association (p for nonlinearity = 0.005) with a threshold at 4.66. Below this threshold, the TC/HDL-C ratio was negatively associated with osteoporosis (OR: 0.83, 95% CI: 0.72–0.94, p = 0.010), while no significant association was observed above the threshold. In sex-specific analyses, a U-shaped relationship was found in women, with a threshold at 4.35 (p for nonlinearity = 0.0016), but no significant association was found in men. The TC/HDL-C ratio demonstrates a U-shaped association with osteoporosis risk in older adults, particularly in women. Further longitudinal studies are required to validate these findings and determine optimal lipid management strategies for osteoporosis prevention.https://doi.org/10.1038/s41598-025-89537-5OsteoporosisTC/HDL-C ratioLipid metabolismElderly populationNHANES |
| spellingShingle | Chuanwei Zhao Xiaochun Zhang Xu Zhang Bo Zhao Yane Yang Mu Lin Wenli Qiao Zeyao Hu Haijie Yang U-shaped association between TC/HDL-C ratio and osteoporosis risk in older adults Scientific Reports Osteoporosis TC/HDL-C ratio Lipid metabolism Elderly population NHANES |
| title | U-shaped association between TC/HDL-C ratio and osteoporosis risk in older adults |
| title_full | U-shaped association between TC/HDL-C ratio and osteoporosis risk in older adults |
| title_fullStr | U-shaped association between TC/HDL-C ratio and osteoporosis risk in older adults |
| title_full_unstemmed | U-shaped association between TC/HDL-C ratio and osteoporosis risk in older adults |
| title_short | U-shaped association between TC/HDL-C ratio and osteoporosis risk in older adults |
| title_sort | u shaped association between tc hdl c ratio and osteoporosis risk in older adults |
| topic | Osteoporosis TC/HDL-C ratio Lipid metabolism Elderly population NHANES |
| url | https://doi.org/10.1038/s41598-025-89537-5 |
| work_keys_str_mv | AT chuanweizhao ushapedassociationbetweentchdlcratioandosteoporosisriskinolderadults AT xiaochunzhang ushapedassociationbetweentchdlcratioandosteoporosisriskinolderadults AT xuzhang ushapedassociationbetweentchdlcratioandosteoporosisriskinolderadults AT bozhao ushapedassociationbetweentchdlcratioandosteoporosisriskinolderadults AT yaneyang ushapedassociationbetweentchdlcratioandosteoporosisriskinolderadults AT mulin ushapedassociationbetweentchdlcratioandosteoporosisriskinolderadults AT wenliqiao ushapedassociationbetweentchdlcratioandosteoporosisriskinolderadults AT zeyaohu ushapedassociationbetweentchdlcratioandosteoporosisriskinolderadults AT haijieyang ushapedassociationbetweentchdlcratioandosteoporosisriskinolderadults |