Associations between nutrient intake and osteoarthritis based on NHANES 1999 to 2018 cross sectional study
Abstract The relationship between nutrient intake and osteoarthritis (OA) remains unclear. This study utilized data from the National Health and Nutrition Examination Survey (NHANES) in a multi-cycle retrospective cohort study to explore the associations between the intake of six nutrients—carbohydr...
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Nature Portfolio
2025-02-01
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| Online Access: | https://doi.org/10.1038/s41598-025-88847-y |
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| author | Xiaofeng Lv Xinmin Deng Rui Lai Shanshan Liu Zihao Zou Xuechun Dai Yalan Luo Jian Luo Ying Li |
| author_facet | Xiaofeng Lv Xinmin Deng Rui Lai Shanshan Liu Zihao Zou Xuechun Dai Yalan Luo Jian Luo Ying Li |
| author_sort | Xiaofeng Lv |
| collection | DOAJ |
| description | Abstract The relationship between nutrient intake and osteoarthritis (OA) remains unclear. This study utilized data from the National Health and Nutrition Examination Survey (NHANES) in a multi-cycle retrospective cohort study to explore the associations between the intake of six nutrients—carbohydrates, dietary fiber, protein, fat, folate, niacin and OA. This study performed a cross-sectional analysis using NHANES data from 1999 to 2018 to investigate the relationship between the intake of six nutrients and OA. Univariate and multivariate weighted logistic regression models, along with restricted cubic splines (RCS), were applied to assess the associations between nutrient intake and OA. A total of 32,484 participants were included in the study, of whom 1864 were diagnosed with OA, resulting in a prevalence rate of 5.74%. Multivariate weighted logistic regression consistently demonstrated that dietary fiber, folic acid, and nicotinic acid intake were negatively associated with the presence of OA, while protein intake exhibited a J-shaped relationship with OA, and carbohydrate or fat intake showed no significant association with OA. Compared with participants in the lowest quartile (Q1), those in the highest quartile (Q4) of dietary fiber, folic acid, and nicotinic acid intake had 27%, 28%, and 33% lower odds of having OA, respectively, after adjusting for potential confounding factors. RCS analysis revealed that dietary fiber and nicotinic acid intake had a nonlinear relationship with the presence of OA, folic acid intake had a linear relationship with OA, and protein intake followed a J-shaped curve with OA. These results suggest that higher intake of dietary fiber, folic acid, and nicotinic acid is associated with a reduced likelihood of OA, while protein intake follows a J-shaped curve, with moderate intake offering the greatest protection. These findings highlight the importance of balancing protein intake and optimizing the consumption of other nutrients for the prevention and management of OA. Further research is needed to confirm these findings and clarify the underlying mechanisms. |
| format | Article |
| id | doaj-art-e82daf835b784ce49fbe8931673c1957 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-e82daf835b784ce49fbe8931673c19572025-02-09T12:33:38ZengNature PortfolioScientific Reports2045-23222025-02-011511910.1038/s41598-025-88847-yAssociations between nutrient intake and osteoarthritis based on NHANES 1999 to 2018 cross sectional studyXiaofeng Lv0Xinmin Deng1Rui Lai2Shanshan Liu3Zihao Zou4Xuechun Dai5Yalan Luo6Jian Luo7Ying Li8School of Acupuncture and Tuina, Chengdu University of Traditional Chinese MedicineSchool of Clinical Medicine, Chengdu University of Traditional Chinese MedicineSchool of Acupuncture and Tuina, Chengdu University of Traditional Chinese MedicineSichuan Integrative Medicine Hospital, ChengduSchool of Acupuncture and Tuina, Chengdu University of Traditional Chinese MedicineSchool of Acupuncture and Tuina, Chengdu University of Traditional Chinese MedicineSchool of Acupuncture and Tuina, Chengdu University of Traditional Chinese MedicineHospital of Chengdu University of Traditional Chinese MedicineSchool of Acupuncture and Tuina, Chengdu University of Traditional Chinese MedicineAbstract The relationship between nutrient intake and osteoarthritis (OA) remains unclear. This study utilized data from the National Health and Nutrition Examination Survey (NHANES) in a multi-cycle retrospective cohort study to explore the associations between the intake of six nutrients—carbohydrates, dietary fiber, protein, fat, folate, niacin and OA. This study performed a cross-sectional analysis using NHANES data from 1999 to 2018 to investigate the relationship between the intake of six nutrients and OA. Univariate and multivariate weighted logistic regression models, along with restricted cubic splines (RCS), were applied to assess the associations between nutrient intake and OA. A total of 32,484 participants were included in the study, of whom 1864 were diagnosed with OA, resulting in a prevalence rate of 5.74%. Multivariate weighted logistic regression consistently demonstrated that dietary fiber, folic acid, and nicotinic acid intake were negatively associated with the presence of OA, while protein intake exhibited a J-shaped relationship with OA, and carbohydrate or fat intake showed no significant association with OA. Compared with participants in the lowest quartile (Q1), those in the highest quartile (Q4) of dietary fiber, folic acid, and nicotinic acid intake had 27%, 28%, and 33% lower odds of having OA, respectively, after adjusting for potential confounding factors. RCS analysis revealed that dietary fiber and nicotinic acid intake had a nonlinear relationship with the presence of OA, folic acid intake had a linear relationship with OA, and protein intake followed a J-shaped curve with OA. These results suggest that higher intake of dietary fiber, folic acid, and nicotinic acid is associated with a reduced likelihood of OA, while protein intake follows a J-shaped curve, with moderate intake offering the greatest protection. These findings highlight the importance of balancing protein intake and optimizing the consumption of other nutrients for the prevention and management of OA. Further research is needed to confirm these findings and clarify the underlying mechanisms.https://doi.org/10.1038/s41598-025-88847-yOsteoarthritisNHANESCross-sectional studyRCSNutrients |
| spellingShingle | Xiaofeng Lv Xinmin Deng Rui Lai Shanshan Liu Zihao Zou Xuechun Dai Yalan Luo Jian Luo Ying Li Associations between nutrient intake and osteoarthritis based on NHANES 1999 to 2018 cross sectional study Scientific Reports Osteoarthritis NHANES Cross-sectional study RCS Nutrients |
| title | Associations between nutrient intake and osteoarthritis based on NHANES 1999 to 2018 cross sectional study |
| title_full | Associations between nutrient intake and osteoarthritis based on NHANES 1999 to 2018 cross sectional study |
| title_fullStr | Associations between nutrient intake and osteoarthritis based on NHANES 1999 to 2018 cross sectional study |
| title_full_unstemmed | Associations between nutrient intake and osteoarthritis based on NHANES 1999 to 2018 cross sectional study |
| title_short | Associations between nutrient intake and osteoarthritis based on NHANES 1999 to 2018 cross sectional study |
| title_sort | associations between nutrient intake and osteoarthritis based on nhanes 1999 to 2018 cross sectional study |
| topic | Osteoarthritis NHANES Cross-sectional study RCS Nutrients |
| url | https://doi.org/10.1038/s41598-025-88847-y |
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