Sirtuin activators as an anti-aging intervention for longevity
Sirtuins are a family of NAD+-dependent class III histone deacetylases that regulate histones and other proteins. The mammalian sirtuins comprise seven members that have a role in energy metabolism, DNA repair, inflammation, cell survival, apoptosis, cellular senescence, oxidative stress, and mitoch...
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| Format: | Article |
| Language: | English |
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Open Exploration
2025-01-01
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| Series: | Exploration of Drug Science |
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| Online Access: | https://www.explorationpub.com/uploads/Article/A100881/100881.pdf |
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| author | Puja Sah Anita K. Rai Donkupar Syiem |
| author_facet | Puja Sah Anita K. Rai Donkupar Syiem |
| author_sort | Puja Sah |
| collection | DOAJ |
| description | Sirtuins are a family of NAD+-dependent class III histone deacetylases that regulate histones and other proteins. The mammalian sirtuins comprise seven members that have a role in energy metabolism, DNA repair, inflammation, cell survival, apoptosis, cellular senescence, oxidative stress, and mitochondrial production. Sirtuin modulation may have beneficial effects on aging and age-related diseases; thus, attracting a growing interest in discovering small molecules modifying their activity. A class of compounds both natural and chemically synthesized has emerged as sirtuin activators. This review discusses mammalian sirtuins in aging, the small molecules that activate sirtuins, modulation of sirtuin activity, and its impact in alleviating the effects of aging. |
| format | Article |
| id | doaj-art-e8b864680b05467a90e554c4f596d2eb |
| institution | Kabale University |
| issn | 2836-7677 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Open Exploration |
| record_format | Article |
| series | Exploration of Drug Science |
| spelling | doaj-art-e8b864680b05467a90e554c4f596d2eb2025-02-08T03:05:27ZengOpen ExplorationExploration of Drug Science2836-76772025-01-01310088110.37349/eds.2025.100881Sirtuin activators as an anti-aging intervention for longevityPuja Sah0https://orcid.org/0009-0000-4419-5979Anita K. Rai1https://orcid.org/0000-0001-6195-9280Donkupar Syiem2https://orcid.org/0000-0002-6569-2680Department of Biochemistry, North-Eastern Hill University, Shillong 793022, Meghalaya, IndiaDepartment of Biochemistry, North-Eastern Hill University, Shillong 793022, Meghalaya, IndiaDepartment of Biochemistry, North-Eastern Hill University, Shillong 793022, Meghalaya, IndiaSirtuins are a family of NAD+-dependent class III histone deacetylases that regulate histones and other proteins. The mammalian sirtuins comprise seven members that have a role in energy metabolism, DNA repair, inflammation, cell survival, apoptosis, cellular senescence, oxidative stress, and mitochondrial production. Sirtuin modulation may have beneficial effects on aging and age-related diseases; thus, attracting a growing interest in discovering small molecules modifying their activity. A class of compounds both natural and chemically synthesized has emerged as sirtuin activators. This review discusses mammalian sirtuins in aging, the small molecules that activate sirtuins, modulation of sirtuin activity, and its impact in alleviating the effects of aging.https://www.explorationpub.com/uploads/Article/A100881/100881.pdfsirtuinsactivatorsagingresveratrolnad+ |
| spellingShingle | Puja Sah Anita K. Rai Donkupar Syiem Sirtuin activators as an anti-aging intervention for longevity Exploration of Drug Science sirtuins activators aging resveratrol nad+ |
| title | Sirtuin activators as an anti-aging intervention for longevity |
| title_full | Sirtuin activators as an anti-aging intervention for longevity |
| title_fullStr | Sirtuin activators as an anti-aging intervention for longevity |
| title_full_unstemmed | Sirtuin activators as an anti-aging intervention for longevity |
| title_short | Sirtuin activators as an anti-aging intervention for longevity |
| title_sort | sirtuin activators as an anti aging intervention for longevity |
| topic | sirtuins activators aging resveratrol nad+ |
| url | https://www.explorationpub.com/uploads/Article/A100881/100881.pdf |
| work_keys_str_mv | AT pujasah sirtuinactivatorsasanantiaginginterventionforlongevity AT anitakrai sirtuinactivatorsasanantiaginginterventionforlongevity AT donkuparsyiem sirtuinactivatorsasanantiaginginterventionforlongevity |