Pathology and diagnostic approaches to well-differentiated hepatocellular lesions: a narrative review

Well-differentiated hepatocellular lesions (WDHLs) are liver tumors or nonneoplastic lesions in which the cells closely resemble normal hepatocytes. These lesions often include focal nodular hyperplasia, hepatocellular adenoma, macroregenerative nodule, dysplastic nodule, and well-differentiated hep...

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Bibliographic Details
Main Authors: Joon Hyuk Choi, Swan N. Thung
Format: Article
Language:English
Published: Yeungnam University College of Medicine, Yeungnam University Institute Medical Science 2025-01-01
Series:Journal of Yeungnam Medical Science
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Online Access:http://www.e-jyms.org/upload/pdf/jyms-2024-00766.pdf
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Summary:Well-differentiated hepatocellular lesions (WDHLs) are liver tumors or nonneoplastic lesions in which the cells closely resemble normal hepatocytes. These lesions often include focal nodular hyperplasia, hepatocellular adenoma, macroregenerative nodule, dysplastic nodule, and well-differentiated hepatocellular carcinoma. The diagnosis of these lesions remains challenging because of their morphological similarities, particularly when examined using needle biopsy. The accurate diagnosis of WDHLs is crucial for patient management and prognosis. This review addresses the histopathological characteristics and diagnostic approaches of WDHLs.
ISSN:2799-8010