A novel truncated fusion gene ETV6::AC010198.2 in post-MPN acute myeloid leukemia caused by del(12)(p13p11)
The gene ETV6 has been confirmed to be a genetic susceptibility gene for thrombocytopenia and leukemia. Here, we report a long-chain noncoding RNA AC010198.2 as a novel fusion partner of ETV6, showing a karyotype of del(12)(p13p11), with poor prognosis in a post-MPN AML that has never been reported,...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1495182/full |
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| author | Jiao Lu Jiao Lu Guanqun Yang Qiurong Zhang Man Wang Man Wang Lijun Wang Lijun Wang Lu Chen Haoyue Chen Xin Jiang Chunhua Liu Tong Lin Qiaoyan Han Zefa Liu Shi Zhen Zhao Zeng Jinlan Pan Jiannong Cen Suning Chen Suning Chen Zheng Wang Zheng Wang Xingxia Zhang Miao Sun |
| author_facet | Jiao Lu Jiao Lu Guanqun Yang Qiurong Zhang Man Wang Man Wang Lijun Wang Lijun Wang Lu Chen Haoyue Chen Xin Jiang Chunhua Liu Tong Lin Qiaoyan Han Zefa Liu Shi Zhen Zhao Zeng Jinlan Pan Jiannong Cen Suning Chen Suning Chen Zheng Wang Zheng Wang Xingxia Zhang Miao Sun |
| author_sort | Jiao Lu |
| collection | DOAJ |
| description | The gene ETV6 has been confirmed to be a genetic susceptibility gene for thrombocytopenia and leukemia. Here, we report a long-chain noncoding RNA AC010198.2 as a novel fusion partner of ETV6, showing a karyotype of del(12)(p13p11), with poor prognosis in a post-MPN AML that has never been reported, which may be an vital initial event in the transformation of MPN to AML and deterioration of disease. |
| format | Article |
| id | doaj-art-e9d693ef80b847e08b1eac5388359fd7 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-e9d693ef80b847e08b1eac5388359fd72025-02-11T06:59:51ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-02-011510.3389/fonc.2025.14951821495182A novel truncated fusion gene ETV6::AC010198.2 in post-MPN acute myeloid leukemia caused by del(12)(p13p11)Jiao Lu0Jiao Lu1Guanqun Yang2Qiurong Zhang3Man Wang4Man Wang5Lijun Wang6Lijun Wang7Lu Chen8Haoyue Chen9Xin Jiang10Chunhua Liu11Tong Lin12Qiaoyan Han13Zefa Liu14Shi Zhen15Zhao Zeng16Jinlan Pan17Jiannong Cen18Suning Chen19Suning Chen20Zheng Wang21Zheng Wang22Xingxia Zhang23Miao Sun24Department of Hematology, Jingjiang People’s Hospital Affiliated to Yangzhou University, Taizhou, Jiangsu, ChinaNational Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Soochow University, Suzhou, ChinaChangshu Hospital Affiliated to Soochow University, Changshu No.1 People’s Hospital, Suzhou, Jiangsu, ChinaDepartment of Hematology, The Affiliated Zhangjiagang Hospital of Soochow University, Suzhou, Jiangsu, ChinaNational Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Soochow University, Suzhou, ChinaInstitute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, ChinaNational Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Soochow University, Suzhou, ChinaInstitute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, ChinaDepartment of Hematology, Jingjiang People’s Hospital Affiliated to Yangzhou University, Taizhou, Jiangsu, ChinaDepartment of Hematology, Jingjiang People’s Hospital Affiliated to Yangzhou University, Taizhou, Jiangsu, ChinaDepartment of Hematology, Jingjiang People’s Hospital Affiliated to Yangzhou University, Taizhou, Jiangsu, ChinaDepartment of Hematology, Jingjiang People’s Hospital Affiliated to Yangzhou University, Taizhou, Jiangsu, ChinaDepartment of Hematology, Jingjiang People’s Hospital Affiliated to Yangzhou University, Taizhou, Jiangsu, ChinaDepartment of Hematology, Jingjiang People’s Hospital Affiliated to Yangzhou University, Taizhou, Jiangsu, ChinaDepartment of Hematology, People’s Hospital of Xinghua City, Taizhou, Jiangsu, ChinaNational Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Soochow University, Suzhou, ChinaNational Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Soochow University, Suzhou, ChinaNational Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Soochow University, Suzhou, ChinaNational Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Soochow University, Suzhou, ChinaNational Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Soochow University, Suzhou, ChinaInstitute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, ChinaNational Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Soochow University, Suzhou, ChinaDepartment of Hematology, Suzhou Jsuniwell Medical Laboratory, Suzhou, ChinaDepartment of Hematology, Huai’an Hospital Affiliated to Xuzhou Medical College and Huai’an Second People’s Hospital, Huai’an, Jiangsu, ChinaDepartment of Hematology, Jingjiang People’s Hospital Affiliated to Yangzhou University, Taizhou, Jiangsu, ChinaThe gene ETV6 has been confirmed to be a genetic susceptibility gene for thrombocytopenia and leukemia. Here, we report a long-chain noncoding RNA AC010198.2 as a novel fusion partner of ETV6, showing a karyotype of del(12)(p13p11), with poor prognosis in a post-MPN AML that has never been reported, which may be an vital initial event in the transformation of MPN to AML and deterioration of disease.https://www.frontiersin.org/articles/10.3389/fonc.2025.1495182/fullAC010198.2novelMPNAMLETV6 |
| spellingShingle | Jiao Lu Jiao Lu Guanqun Yang Qiurong Zhang Man Wang Man Wang Lijun Wang Lijun Wang Lu Chen Haoyue Chen Xin Jiang Chunhua Liu Tong Lin Qiaoyan Han Zefa Liu Shi Zhen Zhao Zeng Jinlan Pan Jiannong Cen Suning Chen Suning Chen Zheng Wang Zheng Wang Xingxia Zhang Miao Sun A novel truncated fusion gene ETV6::AC010198.2 in post-MPN acute myeloid leukemia caused by del(12)(p13p11) Frontiers in Oncology AC010198.2 novel MPN AML ETV6 |
| title | A novel truncated fusion gene ETV6::AC010198.2 in post-MPN acute myeloid leukemia caused by del(12)(p13p11) |
| title_full | A novel truncated fusion gene ETV6::AC010198.2 in post-MPN acute myeloid leukemia caused by del(12)(p13p11) |
| title_fullStr | A novel truncated fusion gene ETV6::AC010198.2 in post-MPN acute myeloid leukemia caused by del(12)(p13p11) |
| title_full_unstemmed | A novel truncated fusion gene ETV6::AC010198.2 in post-MPN acute myeloid leukemia caused by del(12)(p13p11) |
| title_short | A novel truncated fusion gene ETV6::AC010198.2 in post-MPN acute myeloid leukemia caused by del(12)(p13p11) |
| title_sort | novel truncated fusion gene etv6 ac010198 2 in post mpn acute myeloid leukemia caused by del 12 p13p11 |
| topic | AC010198.2 novel MPN AML ETV6 |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1495182/full |
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