The rhabdoid variant of adrenocortical carcinoma-Report of three cases and literature review
Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy. Extensive rhabdoid morphology in ACC has been described recently in very few cases. The proportion of rhabdoid morphology and the role of SMARCB1/ INI1 expression in these tumor cells to diagnose the specific variant is not describe...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-07-01
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| Series: | Indian Journal of Pathology and Microbiology |
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| Online Access: | https://journals.lww.com/10.4103/ijpm.ijpm_515_21 |
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| author | Pavithra Ayyanar Mukund N. Sable Amit K. Adhya Manoj K. Das Madhabananda Kar Pritinanda Mishra |
| author_facet | Pavithra Ayyanar Mukund N. Sable Amit K. Adhya Manoj K. Das Madhabananda Kar Pritinanda Mishra |
| author_sort | Pavithra Ayyanar |
| collection | DOAJ |
| description | Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy. Extensive rhabdoid morphology in ACC has been described recently in very few cases. The proportion of rhabdoid morphology and the role of SMARCB1/ INI1 expression in these tumor cells to diagnose the specific variant is not described in the literature. We reviewed the clinicopathological features of nine cases of adrenocortical neoplasm. Out of which, three cases of ACC showed predominant rhabdoid morphology. Large discohesive cells with abundant cytoplasm containing eosinophilic inclusions, eccentric vesicular nucleus, and prominent nucleoli. INI1 immunostain was retained in all cases. We reported the rhabdoid variant of ACC, a novel entity, and its diagnostic approach from their histological mimickers. Identifying more cases of this entity will help to clearly understand the pathogenesis, biologic behaviour, and any specific molecular alterations in the future. |
| format | Article |
| id | doaj-art-e9f67fb00f5a4bfe84cd093fc5b4f7d4 |
| institution | Kabale University |
| issn | 0377-4929 |
| language | English |
| publishDate | 2023-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj-art-e9f67fb00f5a4bfe84cd093fc5b4f7d42025-02-07T13:35:16ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49292023-07-0166362763110.4103/ijpm.ijpm_515_21The rhabdoid variant of adrenocortical carcinoma-Report of three cases and literature reviewPavithra AyyanarMukund N. SableAmit K. AdhyaManoj K. DasMadhabananda KarPritinanda MishraAdrenocortical carcinoma (ACC) is a rare and aggressive malignancy. Extensive rhabdoid morphology in ACC has been described recently in very few cases. The proportion of rhabdoid morphology and the role of SMARCB1/ INI1 expression in these tumor cells to diagnose the specific variant is not described in the literature. We reviewed the clinicopathological features of nine cases of adrenocortical neoplasm. Out of which, three cases of ACC showed predominant rhabdoid morphology. Large discohesive cells with abundant cytoplasm containing eosinophilic inclusions, eccentric vesicular nucleus, and prominent nucleoli. INI1 immunostain was retained in all cases. We reported the rhabdoid variant of ACC, a novel entity, and its diagnostic approach from their histological mimickers. Identifying more cases of this entity will help to clearly understand the pathogenesis, biologic behaviour, and any specific molecular alterations in the future.https://journals.lww.com/10.4103/ijpm.ijpm_515_21adrenocortical carcinomainii1rhabdoid variantsmarcb1 |
| spellingShingle | Pavithra Ayyanar Mukund N. Sable Amit K. Adhya Manoj K. Das Madhabananda Kar Pritinanda Mishra The rhabdoid variant of adrenocortical carcinoma-Report of three cases and literature review Indian Journal of Pathology and Microbiology adrenocortical carcinoma inii1 rhabdoid variant smarcb1 |
| title | The rhabdoid variant of adrenocortical carcinoma-Report of three cases and literature review |
| title_full | The rhabdoid variant of adrenocortical carcinoma-Report of three cases and literature review |
| title_fullStr | The rhabdoid variant of adrenocortical carcinoma-Report of three cases and literature review |
| title_full_unstemmed | The rhabdoid variant of adrenocortical carcinoma-Report of three cases and literature review |
| title_short | The rhabdoid variant of adrenocortical carcinoma-Report of three cases and literature review |
| title_sort | rhabdoid variant of adrenocortical carcinoma report of three cases and literature review |
| topic | adrenocortical carcinoma inii1 rhabdoid variant smarcb1 |
| url | https://journals.lww.com/10.4103/ijpm.ijpm_515_21 |
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