Organizing collective cell migration through guidance by followers
Morphogenesis, wound healing, and some cancer metastases rely on the collective migration of groups of cells. In these processes, guidance and coordination between cells and tissues are critical. While strongly adherent epithelial cells have to move collectively, loosely organized mesenchymal cells...
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| Format: | Article |
| Language: | English |
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Académie des sciences
2023-12-01
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| Series: | Comptes Rendus Biologies |
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| Online Access: | https://comptes-rendus.academie-sciences.fr/biologies/articles/10.5802/crbiol.145/ |
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| author | Boutillon, Arthur |
| author_facet | Boutillon, Arthur |
| author_sort | Boutillon, Arthur |
| collection | DOAJ |
| description | Morphogenesis, wound healing, and some cancer metastases rely on the collective migration of groups of cells. In these processes, guidance and coordination between cells and tissues are critical. While strongly adherent epithelial cells have to move collectively, loosely organized mesenchymal cells can migrate as individual cells. Nevertheless, many of them migrate collectively. This article summarizes how migratory reactions to cell–cell contacts, also called “contact regulation of locomotion” behaviors, organize mesenchymal collective cell migration. It focuses on one recently discovered mechanism called “guidance by followers”, through which a cell is oriented by its immediate followers. In the gastrulating zebrafish embryo, during embryonic axis elongation, this phenomenon is responsible for the collective migration of the leading tissue, the polster, and its guidance by the following posterior axial mesoderm. Such guidance of migrating cells by followers ensures long-range coordination of movements and developmental robustness. Along with other “contact regulation of locomotion” behaviors, this mechanism contributes to organizing collective migration of loose populations of cells. |
| format | Article |
| id | doaj-art-e9fdccb9580d44798acb26cd9e437533 |
| institution | Kabale University |
| issn | 1768-3238 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Académie des sciences |
| record_format | Article |
| series | Comptes Rendus Biologies |
| spelling | doaj-art-e9fdccb9580d44798acb26cd9e4375332025-02-07T10:37:08ZengAcadémie des sciencesComptes Rendus Biologies1768-32382023-12-01346G211712610.5802/crbiol.14510.5802/crbiol.145Organizing collective cell migration through guidance by followers Boutillon, Arthur0https://orcid.org/0000-0002-0968-6059Cluster of Excellence Physics of Life, Technische Universität Dresden, 01062 Dresden, GermanyMorphogenesis, wound healing, and some cancer metastases rely on the collective migration of groups of cells. In these processes, guidance and coordination between cells and tissues are critical. While strongly adherent epithelial cells have to move collectively, loosely organized mesenchymal cells can migrate as individual cells. Nevertheless, many of them migrate collectively. This article summarizes how migratory reactions to cell–cell contacts, also called “contact regulation of locomotion” behaviors, organize mesenchymal collective cell migration. It focuses on one recently discovered mechanism called “guidance by followers”, through which a cell is oriented by its immediate followers. In the gastrulating zebrafish embryo, during embryonic axis elongation, this phenomenon is responsible for the collective migration of the leading tissue, the polster, and its guidance by the following posterior axial mesoderm. Such guidance of migrating cells by followers ensures long-range coordination of movements and developmental robustness. Along with other “contact regulation of locomotion” behaviors, this mechanism contributes to organizing collective migration of loose populations of cells.https://comptes-rendus.academie-sciences.fr/biologies/articles/10.5802/crbiol.145/Collective cell migrationEmbryonic developmentMechanosensationCell polarizationZebrafishMesenchymal cellMesoderm |
| spellingShingle | Boutillon, Arthur Organizing collective cell migration through guidance by followers Comptes Rendus Biologies Collective cell migration Embryonic development Mechanosensation Cell polarization Zebrafish Mesenchymal cell Mesoderm |
| title | Organizing collective cell migration through guidance by followers
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| title_full | Organizing collective cell migration through guidance by followers
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| title_fullStr | Organizing collective cell migration through guidance by followers
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| title_full_unstemmed | Organizing collective cell migration through guidance by followers
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| title_short | Organizing collective cell migration through guidance by followers
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| title_sort | organizing collective cell migration through guidance by followers |
| topic | Collective cell migration Embryonic development Mechanosensation Cell polarization Zebrafish Mesenchymal cell Mesoderm |
| url | https://comptes-rendus.academie-sciences.fr/biologies/articles/10.5802/crbiol.145/ |
| work_keys_str_mv | AT boutillonarthur organizingcollectivecellmigrationthroughguidancebyfollowers |