Diagnostic value of cerebrospinal fluid levels of D-lactate, tumour necrosis factor-alpha and interleukin-6, -8, and -17 in suspected nosocomial meningitis
Introduction: This study aimed to determine the diagnostic value of interleukin (IL)-6, IL-8, IL-17, tumour necrosis factor-alpha (TNF-α) and D-lactate levels in the cerebrospinal fluid (CSF) of nosocomial meningitis patients. Methods: The CSF levels of cytokines and D-lactate were compared across 2...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer – Medknow Publications
2024-08-01
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| Series: | Singapore Medical Journal |
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| Online Access: | https://journals.lww.com/10.11622/smedj.2021123 |
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| author | Sibel Yorulmaz Goktas Arzu Yılmaztepe Oral Emel Yılmaz Emin Halis Akalın Furkan Guvenc Guven Ozkaya Hasan Kocaeli Seref Dogan Selcuk Yılmazlar Haluk Barbaros Oral |
| author_facet | Sibel Yorulmaz Goktas Arzu Yılmaztepe Oral Emel Yılmaz Emin Halis Akalın Furkan Guvenc Guven Ozkaya Hasan Kocaeli Seref Dogan Selcuk Yılmazlar Haluk Barbaros Oral |
| author_sort | Sibel Yorulmaz Goktas |
| collection | DOAJ |
| description | Introduction:
This study aimed to determine the diagnostic value of interleukin (IL)-6, IL-8, IL-17, tumour necrosis factor-alpha (TNF-α) and D-lactate levels in the cerebrospinal fluid (CSF) of nosocomial meningitis patients.
Methods:
The CSF levels of cytokines and D-lactate were compared across 29 episodes of nosocomial meningitis, 38 episodes of pleocytosis (without meningitis) and 54 control subjects.
Results:
The CSF levels of IL-6, IL-8, and D-lactate were higher in the group with nosocomial meningitis compared to the control group and the group with pleocytosis without meningitis (P < 0.05). For IL-6 levels (threshold: >440 pg/mL), the sensitivity and specificity were 55.17% and 94.74%, respectively. For IL-8 levels (threshold: >1,249 pg/mL), the sensitivity and specificity were 44.83% and 84.21%, respectively. In patients with nosocomial meningitis, when the threshold of D-lactate levels was >1.05 μmol/mL, the sensitivity and specificity were 75.86% and 63.16%, respectively. In pleocytosis (without meningitis) CSF samples and in nosocomial meningitis CSF samples, the highest area under the receiver operating characteristic curve (AUC) was calculated for triple combination model of IL-6, IL-8 and D-lactate levels (AUC 0.801, P < 0.001) and double combination model of IL-6 and IL-8 (AUC 0.790, P < 0.001).
Conclusion:
Our study findings suggest that IL-6, IL-8 and D-lactate levels could be diagnostic markers for nosocomial meningitis. |
| format | Article |
| id | doaj-art-eb0cf287990f4a4aa08f159269de52b7 |
| institution | Kabale University |
| issn | 0037-5675 2737-5935 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | Wolters Kluwer – Medknow Publications |
| record_format | Article |
| series | Singapore Medical Journal |
| spelling | doaj-art-eb0cf287990f4a4aa08f159269de52b72025-02-09T10:23:48ZengWolters Kluwer – Medknow PublicationsSingapore Medical Journal0037-56752737-59352024-08-0165843043710.11622/smedj.2021123Diagnostic value of cerebrospinal fluid levels of D-lactate, tumour necrosis factor-alpha and interleukin-6, -8, and -17 in suspected nosocomial meningitisSibel Yorulmaz GoktasArzu Yılmaztepe OralEmel YılmazEmin Halis AkalınFurkan GuvencGuven OzkayaHasan KocaeliSeref DoganSelcuk YılmazlarHaluk Barbaros OralIntroduction: This study aimed to determine the diagnostic value of interleukin (IL)-6, IL-8, IL-17, tumour necrosis factor-alpha (TNF-α) and D-lactate levels in the cerebrospinal fluid (CSF) of nosocomial meningitis patients. Methods: The CSF levels of cytokines and D-lactate were compared across 29 episodes of nosocomial meningitis, 38 episodes of pleocytosis (without meningitis) and 54 control subjects. Results: The CSF levels of IL-6, IL-8, and D-lactate were higher in the group with nosocomial meningitis compared to the control group and the group with pleocytosis without meningitis (P < 0.05). For IL-6 levels (threshold: >440 pg/mL), the sensitivity and specificity were 55.17% and 94.74%, respectively. For IL-8 levels (threshold: >1,249 pg/mL), the sensitivity and specificity were 44.83% and 84.21%, respectively. In patients with nosocomial meningitis, when the threshold of D-lactate levels was >1.05 μmol/mL, the sensitivity and specificity were 75.86% and 63.16%, respectively. In pleocytosis (without meningitis) CSF samples and in nosocomial meningitis CSF samples, the highest area under the receiver operating characteristic curve (AUC) was calculated for triple combination model of IL-6, IL-8 and D-lactate levels (AUC 0.801, P < 0.001) and double combination model of IL-6 and IL-8 (AUC 0.790, P < 0.001). Conclusion: Our study findings suggest that IL-6, IL-8 and D-lactate levels could be diagnostic markers for nosocomial meningitis.https://journals.lww.com/10.11622/smedj.2021123cytokined-lactateil-6il-8il-17nosocomial meningitistnf-α |
| spellingShingle | Sibel Yorulmaz Goktas Arzu Yılmaztepe Oral Emel Yılmaz Emin Halis Akalın Furkan Guvenc Guven Ozkaya Hasan Kocaeli Seref Dogan Selcuk Yılmazlar Haluk Barbaros Oral Diagnostic value of cerebrospinal fluid levels of D-lactate, tumour necrosis factor-alpha and interleukin-6, -8, and -17 in suspected nosocomial meningitis Singapore Medical Journal cytokine d-lactate il-6 il-8 il-17 nosocomial meningitis tnf-α |
| title | Diagnostic value of cerebrospinal fluid levels of D-lactate, tumour necrosis factor-alpha and interleukin-6, -8, and -17 in suspected nosocomial meningitis |
| title_full | Diagnostic value of cerebrospinal fluid levels of D-lactate, tumour necrosis factor-alpha and interleukin-6, -8, and -17 in suspected nosocomial meningitis |
| title_fullStr | Diagnostic value of cerebrospinal fluid levels of D-lactate, tumour necrosis factor-alpha and interleukin-6, -8, and -17 in suspected nosocomial meningitis |
| title_full_unstemmed | Diagnostic value of cerebrospinal fluid levels of D-lactate, tumour necrosis factor-alpha and interleukin-6, -8, and -17 in suspected nosocomial meningitis |
| title_short | Diagnostic value of cerebrospinal fluid levels of D-lactate, tumour necrosis factor-alpha and interleukin-6, -8, and -17 in suspected nosocomial meningitis |
| title_sort | diagnostic value of cerebrospinal fluid levels of d lactate tumour necrosis factor alpha and interleukin 6 8 and 17 in suspected nosocomial meningitis |
| topic | cytokine d-lactate il-6 il-8 il-17 nosocomial meningitis tnf-α |
| url | https://journals.lww.com/10.11622/smedj.2021123 |
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