Functional segregation of rostral and caudal hippocampus in associative memory
IntroductionThe hippocampus plays a crucial role in episodic memory. Given its complexity, the hippocampus participates in multiple aspects of higher cognitive functions, among which are semantics-based encoding and retrieval. However, the “where,” “when” and “how” of distinct aspects of memory proc...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnhum.2025.1509163/full |
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| author | Alicia Nunez Vorobiova Matteo Feurra Enea Francesco Pavone Lennart Stieglitz Lukas Imbach Victoria Moiseeva Johannes Sarnthein Tommaso Fedele Tommaso Fedele Tommaso Fedele |
| author_facet | Alicia Nunez Vorobiova Matteo Feurra Enea Francesco Pavone Lennart Stieglitz Lukas Imbach Victoria Moiseeva Johannes Sarnthein Tommaso Fedele Tommaso Fedele Tommaso Fedele |
| author_sort | Alicia Nunez Vorobiova |
| collection | DOAJ |
| description | IntroductionThe hippocampus plays a crucial role in episodic memory. Given its complexity, the hippocampus participates in multiple aspects of higher cognitive functions, among which are semantics-based encoding and retrieval. However, the “where,” “when” and “how” of distinct aspects of memory processing in the hippocampus are still under debate.MethodsHere, we employed a visual associative memory task that involved encoding three levels of subjective congruence to delineate the differential involvement of the rostral and caudal portions (also referred as anterior/posterior portions) of the human hippocampus during memory encoding, recognition and associative recall.ResultsThrough stereo-EEG recordings in epilepsy patients we show that associative memory is reflected by rostral hippocampal activity during encoding, and caudal hippocampal activity during retrieval. In contrast, recognition memory encoding selectively activates the rostral hippocampus. The temporal dynamics of memory processing are manifested by gamma power increase, which partially overlaps with low-frequency power decrease during encoding and retrieval. Congruence levels modulate low-frequency activity prominently in the caudal hippocampus.DiscussionThese findings highlight an anatomical segregation in the hippocampus in accordance with the contributions of its partitions to associative and recognition memory. |
| format | Article |
| id | doaj-art-eb4927e14e16426a94679124b58a50b8 |
| institution | Kabale University |
| issn | 1662-5161 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj-art-eb4927e14e16426a94679124b58a50b82025-02-10T14:02:43ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612025-02-011910.3389/fnhum.2025.15091631509163Functional segregation of rostral and caudal hippocampus in associative memoryAlicia Nunez Vorobiova0Matteo Feurra1Enea Francesco Pavone2Lennart Stieglitz3Lukas Imbach4Victoria Moiseeva5Johannes Sarnthein6Tommaso Fedele7Tommaso Fedele8Tommaso Fedele9Department of Psychology, National Research University Higher School of Economics, Moscow, RussiaCentre for Cognition and Decision Making, Institute for Cognitive Neuroscience, HSE University, Moscow, RussiaBraintrends Ltd., Rome, ItalyUniversity Hospital Zurich, University of Zurich, Zurich, SwitzerlandSwiss Epilepsy Center, Zurich, SwitzerlandCentre for Cognition and Decision Making, Institute for Cognitive Neuroscience, HSE University, Moscow, RussiaUniversity Hospital Zurich, University of Zurich, Zurich, SwitzerlandCentre for Cognition and Decision Making, Institute for Cognitive Neuroscience, HSE University, Moscow, RussiaSwiss Epilepsy Center, Zurich, SwitzerlandChildren's Hospital, University of Zurich, Zurich, SwitzerlandIntroductionThe hippocampus plays a crucial role in episodic memory. Given its complexity, the hippocampus participates in multiple aspects of higher cognitive functions, among which are semantics-based encoding and retrieval. However, the “where,” “when” and “how” of distinct aspects of memory processing in the hippocampus are still under debate.MethodsHere, we employed a visual associative memory task that involved encoding three levels of subjective congruence to delineate the differential involvement of the rostral and caudal portions (also referred as anterior/posterior portions) of the human hippocampus during memory encoding, recognition and associative recall.ResultsThrough stereo-EEG recordings in epilepsy patients we show that associative memory is reflected by rostral hippocampal activity during encoding, and caudal hippocampal activity during retrieval. In contrast, recognition memory encoding selectively activates the rostral hippocampus. The temporal dynamics of memory processing are manifested by gamma power increase, which partially overlaps with low-frequency power decrease during encoding and retrieval. Congruence levels modulate low-frequency activity prominently in the caudal hippocampus.DiscussionThese findings highlight an anatomical segregation in the hippocampus in accordance with the contributions of its partitions to associative and recognition memory.https://www.frontiersin.org/articles/10.3389/fnhum.2025.1509163/fullhippocampusmemoryepilepsystereo-EEGassociative memory |
| spellingShingle | Alicia Nunez Vorobiova Matteo Feurra Enea Francesco Pavone Lennart Stieglitz Lukas Imbach Victoria Moiseeva Johannes Sarnthein Tommaso Fedele Tommaso Fedele Tommaso Fedele Functional segregation of rostral and caudal hippocampus in associative memory Frontiers in Human Neuroscience hippocampus memory epilepsy stereo-EEG associative memory |
| title | Functional segregation of rostral and caudal hippocampus in associative memory |
| title_full | Functional segregation of rostral and caudal hippocampus in associative memory |
| title_fullStr | Functional segregation of rostral and caudal hippocampus in associative memory |
| title_full_unstemmed | Functional segregation of rostral and caudal hippocampus in associative memory |
| title_short | Functional segregation of rostral and caudal hippocampus in associative memory |
| title_sort | functional segregation of rostral and caudal hippocampus in associative memory |
| topic | hippocampus memory epilepsy stereo-EEG associative memory |
| url | https://www.frontiersin.org/articles/10.3389/fnhum.2025.1509163/full |
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