Association between CYP2C19 polymorphism and proton pump inhibitors adverse drug reactions: a narrative review
Proton pump inhibitors (PPIs) are widely prescribed medications for the management of acid-related disorders, due to their effectiveness and favorable pharmacokinetics. However, the occurrence and severity of adverse drug reactions (ADRs) in patients using PPIs, particularly in relation to their ass...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-02-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1523399/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823857026578513920 |
|---|---|
| author | Asmaa Ibrahim Kazeem Yusuff Ahmed Awaisu Hazem Elewa |
| author_facet | Asmaa Ibrahim Kazeem Yusuff Ahmed Awaisu Hazem Elewa |
| author_sort | Asmaa Ibrahim |
| collection | DOAJ |
| description | Proton pump inhibitors (PPIs) are widely prescribed medications for the management of acid-related disorders, due to their effectiveness and favorable pharmacokinetics. However, the occurrence and severity of adverse drug reactions (ADRs) in patients using PPIs, particularly in relation to their association with CYP2C19 polymorphisms, are of great concern. This association has largely been investigated through observational studies, which have shown conflicting or weak findings. Therefore, this review aims to examine the current evidence regarding the long-term ADRs of PPIs and their link to CYP2C19 variants. |
| format | Article |
| id | doaj-art-ebaf508ede464564950198e96d344399 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-ebaf508ede464564950198e96d3443992025-02-12T05:14:57ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-02-011610.3389/fphar.2025.15233991523399Association between CYP2C19 polymorphism and proton pump inhibitors adverse drug reactions: a narrative reviewAsmaa IbrahimKazeem YusuffAhmed AwaisuHazem ElewaProton pump inhibitors (PPIs) are widely prescribed medications for the management of acid-related disorders, due to their effectiveness and favorable pharmacokinetics. However, the occurrence and severity of adverse drug reactions (ADRs) in patients using PPIs, particularly in relation to their association with CYP2C19 polymorphisms, are of great concern. This association has largely been investigated through observational studies, which have shown conflicting or weak findings. Therefore, this review aims to examine the current evidence regarding the long-term ADRs of PPIs and their link to CYP2C19 variants.https://www.frontiersin.org/articles/10.3389/fphar.2025.1523399/fullproton pump inhibitorsadverse drug reactionsCYP2C19 polymorphismpharmacogenomics (PGx)overuse and misuse |
| spellingShingle | Asmaa Ibrahim Kazeem Yusuff Ahmed Awaisu Hazem Elewa Association between CYP2C19 polymorphism and proton pump inhibitors adverse drug reactions: a narrative review Frontiers in Pharmacology proton pump inhibitors adverse drug reactions CYP2C19 polymorphism pharmacogenomics (PGx) overuse and misuse |
| title | Association between CYP2C19 polymorphism and proton pump inhibitors adverse drug reactions: a narrative review |
| title_full | Association between CYP2C19 polymorphism and proton pump inhibitors adverse drug reactions: a narrative review |
| title_fullStr | Association between CYP2C19 polymorphism and proton pump inhibitors adverse drug reactions: a narrative review |
| title_full_unstemmed | Association between CYP2C19 polymorphism and proton pump inhibitors adverse drug reactions: a narrative review |
| title_short | Association between CYP2C19 polymorphism and proton pump inhibitors adverse drug reactions: a narrative review |
| title_sort | association between cyp2c19 polymorphism and proton pump inhibitors adverse drug reactions a narrative review |
| topic | proton pump inhibitors adverse drug reactions CYP2C19 polymorphism pharmacogenomics (PGx) overuse and misuse |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1523399/full |
| work_keys_str_mv | AT asmaaibrahim associationbetweencyp2c19polymorphismandprotonpumpinhibitorsadversedrugreactionsanarrativereview AT kazeemyusuff associationbetweencyp2c19polymorphismandprotonpumpinhibitorsadversedrugreactionsanarrativereview AT ahmedawaisu associationbetweencyp2c19polymorphismandprotonpumpinhibitorsadversedrugreactionsanarrativereview AT hazemelewa associationbetweencyp2c19polymorphismandprotonpumpinhibitorsadversedrugreactionsanarrativereview |