EMT-driven plasticity prospectively increases cell–cell variability to promote therapeutic adaptation in breast cancer

EMT-driven plasticity prospectively increases cell–cell variability to promote therapeutic adaptation in breast cancer

Abstract Cellular plasticity enables cancer cells to adapt non-genetically, thereby preventing therapeutic success. The epithelial-mesenchymal transition (EMT) is a type of plasticity linked to resistance and metastasis. However, its exact impact on population diversity and its dynamics under chemot...

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Main Authors: Lauriane Muller, Frédérique Fauvet, Christelle Chassot, Francesca Angileri, Angèle Coutant, Cyril Dégletagne, Laurie Tonon, Pierre Saintigny, Alain Puisieux, Anne-Pierre Morel, Maria Ouzounova, Pierre Martinez
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Cancer Cell International
Online Access:https://doi.org/10.1186/s12935-025-03637-w
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