Lactobacillus fermentum B153 from human colostrum modulates intestinal immunity and gut microbiota in obese mice model
This study evaluated the effects of L. fermentum B153 (derived from human colostrum) on intestinal immunity and gut microbiota in a high-fat diet-induced obese mouse model. The results indicate that treatment with L. fermentum B153 significantly decreased the perirenal adipose index and increased th...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-02-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464625000040 |
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| Summary: | This study evaluated the effects of L. fermentum B153 (derived from human colostrum) on intestinal immunity and gut microbiota in a high-fat diet-induced obese mouse model. The results indicate that treatment with L. fermentum B153 significantly decreased the perirenal adipose index and increased the villus height to crypt depth (V/C) ratio in both the ileum and jejunum of obese mice. Intestinal inflammation induced by the high-fat diet was alleviated by L. fermentum B153, as evidenced by the upregulation of E-cadherin and IL-6 mRNA expression, alongside the downregulation of TNF-α mRNA expression. Furthermore, L. fermentum B153 significantly altered the gut microbiome composition of obese mice, characterized by a substantial increase in the relative abundance of the potentially beneficial genus Akkermansia and a notable decrease in the richness of potentially harmful bacteria (e.g., Lachnoclostridium, Romboutsia and Dubosiella). In conclusion, L. fermentum B153 positively modulated intestinal immunity and gut microbiota in obese mice. |
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| ISSN: | 1756-4646 |