Lactobacillus fermentum B153 from human colostrum modulates intestinal immunity and gut microbiota in obese mice model
This study evaluated the effects of L. fermentum B153 (derived from human colostrum) on intestinal immunity and gut microbiota in a high-fat diet-induced obese mouse model. The results indicate that treatment with L. fermentum B153 significantly decreased the perirenal adipose index and increased th...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464625000040 |
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| author | Juqing Huang Xiaohui Cai Xiaoyan Liu Gongti Lai Xuefang Guan Bingyan Chen Qi Wang |
| author_facet | Juqing Huang Xiaohui Cai Xiaoyan Liu Gongti Lai Xuefang Guan Bingyan Chen Qi Wang |
| author_sort | Juqing Huang |
| collection | DOAJ |
| description | This study evaluated the effects of L. fermentum B153 (derived from human colostrum) on intestinal immunity and gut microbiota in a high-fat diet-induced obese mouse model. The results indicate that treatment with L. fermentum B153 significantly decreased the perirenal adipose index and increased the villus height to crypt depth (V/C) ratio in both the ileum and jejunum of obese mice. Intestinal inflammation induced by the high-fat diet was alleviated by L. fermentum B153, as evidenced by the upregulation of E-cadherin and IL-6 mRNA expression, alongside the downregulation of TNF-α mRNA expression. Furthermore, L. fermentum B153 significantly altered the gut microbiome composition of obese mice, characterized by a substantial increase in the relative abundance of the potentially beneficial genus Akkermansia and a notable decrease in the richness of potentially harmful bacteria (e.g., Lachnoclostridium, Romboutsia and Dubosiella). In conclusion, L. fermentum B153 positively modulated intestinal immunity and gut microbiota in obese mice. |
| format | Article |
| id | doaj-art-ef581f6fbae9490fb3f4ec18f7c1adc0 |
| institution | Kabale University |
| issn | 1756-4646 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj-art-ef581f6fbae9490fb3f4ec18f7c1adc02025-02-09T04:59:53ZengElsevierJournal of Functional Foods1756-46462025-02-01125106662Lactobacillus fermentum B153 from human colostrum modulates intestinal immunity and gut microbiota in obese mice modelJuqing Huang0Xiaohui Cai1Xiaoyan Liu2Gongti Lai3Xuefang Guan4Bingyan Chen5Qi Wang6Institute of Food Science and Technology, Fujian Academy of Agricultural Sciences, Fuzhou 350003, China; Key Laboratory of Processing of Subtropical Characteristic Fruits, Vegetables and Edible Fungi, Ministry of Agriculture and Rural Affairs of China, Fuzhou 350003, China; Fujian Key Laboratory of Agricultural Product (Food) Processing, Fuzhou 350003, ChinaCollege of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, ChinaBeijing Engineering and Technology Research Center of Food Additives, School of Food and Health, Beijing Technology and Business University, Beijing 100048, ChinaInstitute of Food Science and Technology, Fujian Academy of Agricultural Sciences, Fuzhou 350003, China; Key Laboratory of Processing of Subtropical Characteristic Fruits, Vegetables and Edible Fungi, Ministry of Agriculture and Rural Affairs of China, Fuzhou 350003, China; Fujian Key Laboratory of Agricultural Product (Food) Processing, Fuzhou 350003, ChinaInstitute of Food Science and Technology, Fujian Academy of Agricultural Sciences, Fuzhou 350003, China; Key Laboratory of Processing of Subtropical Characteristic Fruits, Vegetables and Edible Fungi, Ministry of Agriculture and Rural Affairs of China, Fuzhou 350003, China; Fujian Key Laboratory of Agricultural Product (Food) Processing, Fuzhou 350003, ChinaInstitute of Food Science and Technology, Fujian Academy of Agricultural Sciences, Fuzhou 350003, China; Key Laboratory of Processing of Subtropical Characteristic Fruits, Vegetables and Edible Fungi, Ministry of Agriculture and Rural Affairs of China, Fuzhou 350003, China; Fujian Key Laboratory of Agricultural Product (Food) Processing, Fuzhou 350003, ChinaInstitute of Food Science and Technology, Fujian Academy of Agricultural Sciences, Fuzhou 350003, China; Key Laboratory of Processing of Subtropical Characteristic Fruits, Vegetables and Edible Fungi, Ministry of Agriculture and Rural Affairs of China, Fuzhou 350003, China; Fujian Key Laboratory of Agricultural Product (Food) Processing, Fuzhou 350003, China; Corresponding author at: Institute of Food Science and Technology, Fujian Academy of Agricultural Sciences, Fuzhou 350003, China.This study evaluated the effects of L. fermentum B153 (derived from human colostrum) on intestinal immunity and gut microbiota in a high-fat diet-induced obese mouse model. The results indicate that treatment with L. fermentum B153 significantly decreased the perirenal adipose index and increased the villus height to crypt depth (V/C) ratio in both the ileum and jejunum of obese mice. Intestinal inflammation induced by the high-fat diet was alleviated by L. fermentum B153, as evidenced by the upregulation of E-cadherin and IL-6 mRNA expression, alongside the downregulation of TNF-α mRNA expression. Furthermore, L. fermentum B153 significantly altered the gut microbiome composition of obese mice, characterized by a substantial increase in the relative abundance of the potentially beneficial genus Akkermansia and a notable decrease in the richness of potentially harmful bacteria (e.g., Lachnoclostridium, Romboutsia and Dubosiella). In conclusion, L. fermentum B153 positively modulated intestinal immunity and gut microbiota in obese mice.http://www.sciencedirect.com/science/article/pii/S1756464625000040Lactobacillus fermentum B153 from human colostrumObesityGut microbiotaIntestinal immunity |
| spellingShingle | Juqing Huang Xiaohui Cai Xiaoyan Liu Gongti Lai Xuefang Guan Bingyan Chen Qi Wang Lactobacillus fermentum B153 from human colostrum modulates intestinal immunity and gut microbiota in obese mice model Journal of Functional Foods Lactobacillus fermentum B153 from human colostrum Obesity Gut microbiota Intestinal immunity |
| title | Lactobacillus fermentum B153 from human colostrum modulates intestinal immunity and gut microbiota in obese mice model |
| title_full | Lactobacillus fermentum B153 from human colostrum modulates intestinal immunity and gut microbiota in obese mice model |
| title_fullStr | Lactobacillus fermentum B153 from human colostrum modulates intestinal immunity and gut microbiota in obese mice model |
| title_full_unstemmed | Lactobacillus fermentum B153 from human colostrum modulates intestinal immunity and gut microbiota in obese mice model |
| title_short | Lactobacillus fermentum B153 from human colostrum modulates intestinal immunity and gut microbiota in obese mice model |
| title_sort | lactobacillus fermentum b153 from human colostrum modulates intestinal immunity and gut microbiota in obese mice model |
| topic | Lactobacillus fermentum B153 from human colostrum Obesity Gut microbiota Intestinal immunity |
| url | http://www.sciencedirect.com/science/article/pii/S1756464625000040 |
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