Family history of cardiovascular disease and death in patients with out-of-hospital cardiac arrest
Aim: How a family history of cardiovascular disease (CVD) or death influences the risk of out-of-hospital cardiac arrest (OHCA) is unknown. This study examined the prevalence of family histories of CVD and death in patients with OHCA and if these factors were associated with OHCA. Methods: Patients...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Resuscitation Plus |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666520425000268 |
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| author | Magnus Gylling Johanna Krøll Peder Emil Warming Carolina Malta Hansen Fredrik Folke Steen M. Hansen Lars Køber Christian Torp-Pedersen Rodrigue Garcia Jacob Tfelt-Hansen Peter E. Weeke |
| author_facet | Magnus Gylling Johanna Krøll Peder Emil Warming Carolina Malta Hansen Fredrik Folke Steen M. Hansen Lars Køber Christian Torp-Pedersen Rodrigue Garcia Jacob Tfelt-Hansen Peter E. Weeke |
| author_sort | Magnus Gylling |
| collection | DOAJ |
| description | Aim: How a family history of cardiovascular disease (CVD) or death influences the risk of out-of-hospital cardiac arrest (OHCA) is unknown. This study examined the prevalence of family histories of CVD and death in patients with OHCA and if these factors were associated with OHCA. Methods: Patients (<70 years) with OHCA’s of presumed cardiac origin and available kinship information were identified from the Danish Cardiac Arrest Register (2001–2014). Patients with OHCA were matched 1:4 (age, sex, and number of identifiable parents) with individuals from the background population (controls) to compare family histories (events in first-degree relatives before OHCA) of CVD, all-cause death, cardiovascular death, and premature death (death <60 years). In conditional multivariable logistic regressions, we examined associations between parental history and offspring OHCA risk. Results: Of 45,293 patients with OHCA 4,994, were eligible for inclusion (median age 50 years at OHCA, 76% male). Of these 47.7% had a family history of CVD (vs. 42.1% of controls), 68.2% of all-cause death (vs. 60.9%), 23% of premature death (vs. 15.8%) and 33.3% of cardiovascular death (vs. 27%) (p < 0.001 for all). A family history of a single parent with CVD (OR: 1.13, 95%CI: 1.05,1.23), all-cause death (OR: 1.42, 95%CI: 1.29,1.56), cardiovascular death (OR: 1.35, 95%CI: 1.24, 1.47), and premature death (OR: 1.45, 95%CI: 1.32,1.59) were all associated with OHCA (p < 0.001 for all). Conclusion: A family history of CVD and death is more common among patients with OHCA compared to a matched background population, as well as being significantly associated with OHCA. |
| format | Article |
| id | doaj-art-f1b5660389db4326bb1ff1a2d74b8020 |
| institution | Kabale University |
| issn | 2666-5204 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Resuscitation Plus |
| spelling | doaj-art-f1b5660389db4326bb1ff1a2d74b80202025-02-09T05:01:31ZengElsevierResuscitation Plus2666-52042025-03-0122100889Family history of cardiovascular disease and death in patients with out-of-hospital cardiac arrestMagnus Gylling0Johanna Krøll1Peder Emil Warming2Carolina Malta Hansen3Fredrik Folke4Steen M. Hansen5Lars Køber6Christian Torp-Pedersen7Rodrigue Garcia8Jacob Tfelt-Hansen9Peter E. Weeke10Copenhagen University Hospital – Rigshospitalet Copenhagen Denmark; Corresponding author at: Department of Cardiology, Copenhagen University Hospital, Rigshospitalet, Denmark.Copenhagen University Hospital – Rigshospitalet Copenhagen DenmarkCopenhagen University Hospital – Rigshospitalet Copenhagen DenmarkCopenhagen University Hospital – Rigshospitalet Copenhagen Denmark; Copenhagen University Hospital – Herlev and Gentofte Gentofte Denmark; Emergency Medical Services Capital Region of Denmark University of Copenhagen Denmark; Department of Clinical Medicine University of Copenhagen DenmarkCopenhagen University Hospital – Herlev and Gentofte Gentofte Denmark; Emergency Medical Services Capital Region of Denmark University of Copenhagen Denmark; Department of Clinical Medicine University of Copenhagen DenmarkAalborg University Hospital, Aalborg, DenmarkCopenhagen University Hospital – Rigshospitalet Copenhagen DenmarkCopenhagen University Hospital – North Zealand Hilleroed Denmark; Department of Public Health University of Copenhagen DenmarkCopenhagen University Hospital – Rigshospitalet Copenhagen Denmark; Portier University Hospital Portier France; Department of Public Health University of Copenhagen DenmarkCopenhagen University Hospital – Rigshospitalet Copenhagen Denmark; Section of Forensic Genetics Department of Forensic Medicine University of Copenhagen Copenhagen DenmarkCopenhagen University Hospital – Rigshospitalet Copenhagen Denmark; Novo Nordisk Soeborg DenmarkAim: How a family history of cardiovascular disease (CVD) or death influences the risk of out-of-hospital cardiac arrest (OHCA) is unknown. This study examined the prevalence of family histories of CVD and death in patients with OHCA and if these factors were associated with OHCA. Methods: Patients (<70 years) with OHCA’s of presumed cardiac origin and available kinship information were identified from the Danish Cardiac Arrest Register (2001–2014). Patients with OHCA were matched 1:4 (age, sex, and number of identifiable parents) with individuals from the background population (controls) to compare family histories (events in first-degree relatives before OHCA) of CVD, all-cause death, cardiovascular death, and premature death (death <60 years). In conditional multivariable logistic regressions, we examined associations between parental history and offspring OHCA risk. Results: Of 45,293 patients with OHCA 4,994, were eligible for inclusion (median age 50 years at OHCA, 76% male). Of these 47.7% had a family history of CVD (vs. 42.1% of controls), 68.2% of all-cause death (vs. 60.9%), 23% of premature death (vs. 15.8%) and 33.3% of cardiovascular death (vs. 27%) (p < 0.001 for all). A family history of a single parent with CVD (OR: 1.13, 95%CI: 1.05,1.23), all-cause death (OR: 1.42, 95%CI: 1.29,1.56), cardiovascular death (OR: 1.35, 95%CI: 1.24, 1.47), and premature death (OR: 1.45, 95%CI: 1.32,1.59) were all associated with OHCA (p < 0.001 for all). Conclusion: A family history of CVD and death is more common among patients with OHCA compared to a matched background population, as well as being significantly associated with OHCA.http://www.sciencedirect.com/science/article/pii/S2666520425000268Out-of-hospital cardiac arrestFamily HistoryEpidemiology |
| spellingShingle | Magnus Gylling Johanna Krøll Peder Emil Warming Carolina Malta Hansen Fredrik Folke Steen M. Hansen Lars Køber Christian Torp-Pedersen Rodrigue Garcia Jacob Tfelt-Hansen Peter E. Weeke Family history of cardiovascular disease and death in patients with out-of-hospital cardiac arrest Resuscitation Plus Out-of-hospital cardiac arrest Family History Epidemiology |
| title | Family history of cardiovascular disease and death in patients with out-of-hospital cardiac arrest |
| title_full | Family history of cardiovascular disease and death in patients with out-of-hospital cardiac arrest |
| title_fullStr | Family history of cardiovascular disease and death in patients with out-of-hospital cardiac arrest |
| title_full_unstemmed | Family history of cardiovascular disease and death in patients with out-of-hospital cardiac arrest |
| title_short | Family history of cardiovascular disease and death in patients with out-of-hospital cardiac arrest |
| title_sort | family history of cardiovascular disease and death in patients with out of hospital cardiac arrest |
| topic | Out-of-hospital cardiac arrest Family History Epidemiology |
| url | http://www.sciencedirect.com/science/article/pii/S2666520425000268 |
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