The curcumin-loaded zein-shellac nanoparticles using pH-driven method: Fabrication, characterization, and anti-inflammatory effect
Curcumin (Cur), a naturally occurring flavonoid compound, is known for its multiple health benefits. Nevertheless, its bioavailability is greatly restricted due to poor solubility and stability. In order to address this problem, phytic acid was used in a pH-driven method to create curcumin-loaded ze...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464625000349 |
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| author | Xinyi Lv Zijian Wu Limin Wang Peibo Guo Ao Qu Wenjing Liang Pengbo Zheng Yuan Li Wen Zhang |
| author_facet | Xinyi Lv Zijian Wu Limin Wang Peibo Guo Ao Qu Wenjing Liang Pengbo Zheng Yuan Li Wen Zhang |
| author_sort | Xinyi Lv |
| collection | DOAJ |
| description | Curcumin (Cur), a naturally occurring flavonoid compound, is known for its multiple health benefits. Nevertheless, its bioavailability is greatly restricted due to poor solubility and stability. In order to address this problem, phytic acid was used in a pH-driven method to create curcumin-loaded zein-shellac nanoparticles (Zein-SH-CurNPs). The results confirmed that the hydrophobic center of zein-shellac nanoparticles (Zein-SHNPs) effectively encapsulated curcumin, leading to the formation of spherical particles that exhibited an impressive encapsulation efficiency of 96.96 % and a loading capacity of 4.65 %. Curcumin-induced zein fluorescence quenching was found to be static using fluorescence spectroscopy. In vivo colitis experiments conducted on mice disclosed that Zein-SH-CurNP exhibits a protective effect against DSS-induced colitis. Notably, the levels of pro-inflammatory cytokines, namely tumor necrosis factor-α (TNF-α), mouse interleukin-6 (IL-6), and interleukin-1β (IL-1β), were significantly reduced. To summarize, the results suggest that the zein-shellac composites hold potential as advanced nano-delivery structures for insoluble bioactive substances. |
| format | Article |
| id | doaj-art-f1c7f2ff5d9b441982dfcb76579e4ea1 |
| institution | Kabale University |
| issn | 1756-4646 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj-art-f1c7f2ff5d9b441982dfcb76579e4ea12025-02-09T04:59:59ZengElsevierJournal of Functional Foods1756-46462025-02-01125106692The curcumin-loaded zein-shellac nanoparticles using pH-driven method: Fabrication, characterization, and anti-inflammatory effectXinyi Lv0Zijian Wu1Limin Wang2Peibo Guo3Ao Qu4Wenjing Liang5Pengbo Zheng6Yuan Li7Wen Zhang8Tianjin Key Laboratory of Food Science and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, China.Tianjin Key Laboratory of Food Science and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, China.; Key Lab of Agricultural Products Low Carbon Cold Chain, Ministry of Agriculture and Rural Affairs, Tianjin 300134, China.; Corresponding authors at: Tianjin University of Commerce, 409 Guangrong Road, Tianjin, 300134, PR China.Tianjin Key Laboratory of Food Science and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, China.Tianjin Key Laboratory of Food Science and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, China.Tianjin Key Laboratory of Food Science and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, China.Tianjin Key Laboratory of Food Science and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, China.Tianjin Key Laboratory of Food Science and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, China.College of Food Sciences and Nutritional Engineering, China Agricultural University, Beijing 100083, China.Tianjin Key Laboratory of Food Science and Biotechnology, School of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, China.; Key Lab of Agricultural Products Low Carbon Cold Chain, Ministry of Agriculture and Rural Affairs, Tianjin 300134, China.; Corresponding authors at: Tianjin University of Commerce, 409 Guangrong Road, Tianjin, 300134, PR China.Curcumin (Cur), a naturally occurring flavonoid compound, is known for its multiple health benefits. Nevertheless, its bioavailability is greatly restricted due to poor solubility and stability. In order to address this problem, phytic acid was used in a pH-driven method to create curcumin-loaded zein-shellac nanoparticles (Zein-SH-CurNPs). The results confirmed that the hydrophobic center of zein-shellac nanoparticles (Zein-SHNPs) effectively encapsulated curcumin, leading to the formation of spherical particles that exhibited an impressive encapsulation efficiency of 96.96 % and a loading capacity of 4.65 %. Curcumin-induced zein fluorescence quenching was found to be static using fluorescence spectroscopy. In vivo colitis experiments conducted on mice disclosed that Zein-SH-CurNP exhibits a protective effect against DSS-induced colitis. Notably, the levels of pro-inflammatory cytokines, namely tumor necrosis factor-α (TNF-α), mouse interleukin-6 (IL-6), and interleukin-1β (IL-1β), were significantly reduced. To summarize, the results suggest that the zein-shellac composites hold potential as advanced nano-delivery structures for insoluble bioactive substances.http://www.sciencedirect.com/science/article/pii/S1756464625000349CurcuminZeinShellacpH-driven methodBioaccessibilityInflammatory. |
| spellingShingle | Xinyi Lv Zijian Wu Limin Wang Peibo Guo Ao Qu Wenjing Liang Pengbo Zheng Yuan Li Wen Zhang The curcumin-loaded zein-shellac nanoparticles using pH-driven method: Fabrication, characterization, and anti-inflammatory effect Journal of Functional Foods Curcumin Zein Shellac pH-driven method Bioaccessibility Inflammatory. |
| title | The curcumin-loaded zein-shellac nanoparticles using pH-driven method: Fabrication, characterization, and anti-inflammatory effect |
| title_full | The curcumin-loaded zein-shellac nanoparticles using pH-driven method: Fabrication, characterization, and anti-inflammatory effect |
| title_fullStr | The curcumin-loaded zein-shellac nanoparticles using pH-driven method: Fabrication, characterization, and anti-inflammatory effect |
| title_full_unstemmed | The curcumin-loaded zein-shellac nanoparticles using pH-driven method: Fabrication, characterization, and anti-inflammatory effect |
| title_short | The curcumin-loaded zein-shellac nanoparticles using pH-driven method: Fabrication, characterization, and anti-inflammatory effect |
| title_sort | curcumin loaded zein shellac nanoparticles using ph driven method fabrication characterization and anti inflammatory effect |
| topic | Curcumin Zein Shellac pH-driven method Bioaccessibility Inflammatory. |
| url | http://www.sciencedirect.com/science/article/pii/S1756464625000349 |
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