Omega-3 long chain fatty acids and their metabolites in pregnancy outcomes for the modulation of maternal inflammatory- associated causes of preterm delivery, chorioamnionitis and preeclampsia [version 3; peer review: 2 approved]
Preterm birth is a major cause of perinatal complications and neonatal deaths. Furthermore, in the field of obstetrics many clinical entities like uterine contractions or the occurrence of pre- eclampsia remain to be serious complications during pregnancy and represent a major psychological, financi...
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2024-12-01
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| author | Jose Miguel Rizo Theresa Steeb Johanna Eiblwieser Pedro Antonio Regidor |
| author_facet | Jose Miguel Rizo Theresa Steeb Johanna Eiblwieser Pedro Antonio Regidor |
| author_sort | Jose Miguel Rizo |
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| description | Preterm birth is a major cause of perinatal complications and neonatal deaths. Furthermore, in the field of obstetrics many clinical entities like uterine contractions or the occurrence of pre- eclampsia remain to be serious complications during pregnancy and represent a major psychological, financial, and economic burden for society. Several published guidelines, studies and recommendations have highlighted the importance of supplementation of omega-3 long chain polyunsaturated fatty acids (PUFAs) during pregnancy. This narrative review aims at giving an overview on the modern perception of inflammatory processes and the role of specialized pro-resolving mediators (SPMs) in their resolution, especially in obstetrics. Additionally, we highlight the possible role of SPMs in the prevention of obstetric complications through oral supplementation using enriched marine oil nutritional’s. The intake of PUFAs may result in an overall improvement of pregnancy outcomes by contributing to fetal brain growth and neurological development but more importantly though modulation of inflammation-associated pathologies. Especially the use of SPMs represents a promising approach for the management of obstetric and perinatal complications. SPMs are monohydroxylates derived from enriched marine oil nutritional’s that involve certain pro-resolutive metabolites of omega-3 long chains PUFAs and may contribute to an attenuation of inflammatory diseases. This may be obtained through various mechanisms necessary for a proper resolution of inflammation such as the termination of neutrophil tissue infiltration, initiation of phagocytosis, downregulation of pro-inflammatory cytokines or tissue regeneration. In this way, acute and chronic inflammatory diseases associated with serious obstetrical complications can be modulated, which might contribute to an improved pregnancy outcome. |
| format | Article |
| id | doaj-art-f2059b7def6d499891e5c00cd5cc0667 |
| institution | Kabale University |
| issn | 2046-1402 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
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| spelling | doaj-art-f2059b7def6d499891e5c00cd5cc06672025-02-09T01:00:01ZengF1000 Research LtdF1000Research2046-14022024-12-0113176157Omega-3 long chain fatty acids and their metabolites in pregnancy outcomes for the modulation of maternal inflammatory- associated causes of preterm delivery, chorioamnionitis and preeclampsia [version 3; peer review: 2 approved]Jose Miguel Rizo0Theresa Steeb1Johanna Eiblwieser2Pedro Antonio Regidor3https://orcid.org/0000-0002-9551-2847Chemo OTC, Madrid, Madrid, 28050, SpainMedical Department, Exeltis Germany, Ismaning, Adalperostr. 84, 85737, GermanyMedical Department, Exeltis Germany, Ismaning, Adalperostr. 84, 85737, GermanyMedical Department, Exeltis Healthcare, Ismaning, 85737, GermanyPreterm birth is a major cause of perinatal complications and neonatal deaths. Furthermore, in the field of obstetrics many clinical entities like uterine contractions or the occurrence of pre- eclampsia remain to be serious complications during pregnancy and represent a major psychological, financial, and economic burden for society. Several published guidelines, studies and recommendations have highlighted the importance of supplementation of omega-3 long chain polyunsaturated fatty acids (PUFAs) during pregnancy. This narrative review aims at giving an overview on the modern perception of inflammatory processes and the role of specialized pro-resolving mediators (SPMs) in their resolution, especially in obstetrics. Additionally, we highlight the possible role of SPMs in the prevention of obstetric complications through oral supplementation using enriched marine oil nutritional’s. The intake of PUFAs may result in an overall improvement of pregnancy outcomes by contributing to fetal brain growth and neurological development but more importantly though modulation of inflammation-associated pathologies. Especially the use of SPMs represents a promising approach for the management of obstetric and perinatal complications. SPMs are monohydroxylates derived from enriched marine oil nutritional’s that involve certain pro-resolutive metabolites of omega-3 long chains PUFAs and may contribute to an attenuation of inflammatory diseases. This may be obtained through various mechanisms necessary for a proper resolution of inflammation such as the termination of neutrophil tissue infiltration, initiation of phagocytosis, downregulation of pro-inflammatory cytokines or tissue regeneration. In this way, acute and chronic inflammatory diseases associated with serious obstetrical complications can be modulated, which might contribute to an improved pregnancy outcome.https://f1000research.com/articles/13-882/v3pregnancy; specialized pro-resolving mediators; polyunsaturated fatty acids; chronic inflammation; preterm birth; preeclampsia; amniotic inflammation; chorioamnionitiseng |
| spellingShingle | Jose Miguel Rizo Theresa Steeb Johanna Eiblwieser Pedro Antonio Regidor Omega-3 long chain fatty acids and their metabolites in pregnancy outcomes for the modulation of maternal inflammatory- associated causes of preterm delivery, chorioamnionitis and preeclampsia [version 3; peer review: 2 approved] F1000Research pregnancy; specialized pro-resolving mediators; polyunsaturated fatty acids; chronic inflammation; preterm birth; preeclampsia; amniotic inflammation; chorioamnionitis eng |
| title | Omega-3 long chain fatty acids and their metabolites in pregnancy outcomes for the modulation of maternal inflammatory- associated causes of preterm delivery, chorioamnionitis and preeclampsia [version 3; peer review: 2 approved] |
| title_full | Omega-3 long chain fatty acids and their metabolites in pregnancy outcomes for the modulation of maternal inflammatory- associated causes of preterm delivery, chorioamnionitis and preeclampsia [version 3; peer review: 2 approved] |
| title_fullStr | Omega-3 long chain fatty acids and their metabolites in pregnancy outcomes for the modulation of maternal inflammatory- associated causes of preterm delivery, chorioamnionitis and preeclampsia [version 3; peer review: 2 approved] |
| title_full_unstemmed | Omega-3 long chain fatty acids and their metabolites in pregnancy outcomes for the modulation of maternal inflammatory- associated causes of preterm delivery, chorioamnionitis and preeclampsia [version 3; peer review: 2 approved] |
| title_short | Omega-3 long chain fatty acids and their metabolites in pregnancy outcomes for the modulation of maternal inflammatory- associated causes of preterm delivery, chorioamnionitis and preeclampsia [version 3; peer review: 2 approved] |
| title_sort | omega 3 long chain fatty acids and their metabolites in pregnancy outcomes for the modulation of maternal inflammatory associated causes of preterm delivery chorioamnionitis and preeclampsia version 3 peer review 2 approved |
| topic | pregnancy; specialized pro-resolving mediators; polyunsaturated fatty acids; chronic inflammation; preterm birth; preeclampsia; amniotic inflammation; chorioamnionitis eng |
| url | https://f1000research.com/articles/13-882/v3 |
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