Synthesis and kinetic evaluation of analogs of (E)-4-amino-3-methylbut-2-en-1-yl diphosphate, a potent inhibitor of the IspH metalloenzyme

Synthesis and kinetic evaluation of analogs of (E)-4-amino-3-methylbut-2-en-1-yl diphosphate, a potent inhibitor of the IspH metalloenzyme

Our previous research revealed that (E)-4-amino-3-methylbut-2-en-1-yl diphosphate (AMBPP) is one of the best inhibitors of IspH, a [4Fe–4S]-dependent enzyme involved in the methylerythritol phosphate pathway that is a valuable target for the discovery of new antibacterial and antiparasitic drugs as...

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Bibliographic Details
Main Authors: Petit, Benoît Eric, Jobelius, Hannah, Bianchino, Gabriella Ines, Guérin, Mélina, Borel, Franck, Chaignon, Philippe, Seemann, Myriam
Format: Article
Language:English
Published: Académie des sciences 2023-12-01
Series:Comptes Rendus. Chimie
Subjects:
MEP pathway
IspH
LytB
Iron–sulfur clusters
Inhibitor
(<i>E</i>)-4-amino-3-methylbut-2-en-1-yl diphosphate
Anti-infectives
Online Access:https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.254/
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