Evaluation of the Chetomin effect on histopathological features in a murine acute spinal cord injury model
Background: Several research studies have been focused on improving the treatment and prognosis of acute spinal cord injury, as part of this initiative we investigated the use of Chetomin to reduce the inflammatory response in this pathology. Methods: An experimental, prospective, cross-sectional st...
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| Language: | English |
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Elsevier
2025-01-01
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| Series: | World Neurosurgery: X |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590139724001455 |
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| author | Carlos César Bravo-Reyna Vladimir Miranda-Galván Gervith Reyes-Soto R. Vicuña Jorge Alanis-Mendizabal Manuel Escobar-Valderrama David Arango Claudia J. Bautista Victoria Ramírez Gonzalo Torres-Villalobos |
| author_facet | Carlos César Bravo-Reyna Vladimir Miranda-Galván Gervith Reyes-Soto R. Vicuña Jorge Alanis-Mendizabal Manuel Escobar-Valderrama David Arango Claudia J. Bautista Victoria Ramírez Gonzalo Torres-Villalobos |
| author_sort | Carlos César Bravo-Reyna |
| collection | DOAJ |
| description | Background: Several research studies have been focused on improving the treatment and prognosis of acute spinal cord injury, as part of this initiative we investigated the use of Chetomin to reduce the inflammatory response in this pathology. Methods: An experimental, prospective, cross-sectional study was performed using 42 Wistar rats where we analyzed the effect of Chetomin compared to methylprednisolone administered 1 and 8 h after the spinal cord injury in a murine model. Results: Chetomin administration 8h post-injury decreased IL-6 and VEGF expression; and, and its administration 1h post-injury decreased NF-kB expression. Conclusions: Chetomin has anti-inflammatory effects in acute spinal cord injury, whether these effects are observable with other proinflammatory markers should be investigated. |
| format | Article |
| id | doaj-art-f30ae18f3c4345e69b99468b89fe3974 |
| institution | Kabale University |
| issn | 2590-1397 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | World Neurosurgery: X |
| spelling | doaj-art-f30ae18f3c4345e69b99468b89fe39742025-02-10T04:34:50ZengElsevierWorld Neurosurgery: X2590-13972025-01-0125100414Evaluation of the Chetomin effect on histopathological features in a murine acute spinal cord injury modelCarlos César Bravo-Reyna0Vladimir Miranda-Galván1Gervith Reyes-Soto2R. Vicuña3Jorge Alanis-Mendizabal4Manuel Escobar-Valderrama5David Arango6Claudia J. Bautista7Victoria Ramírez8Gonzalo Torres-Villalobos9Department of Experimental Surgery, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan, Zip code 14080, Mexico; Corresponding author. Experimental Surgery Department. Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán”, Vasco de Quiroga # 15 Belisario Domínguez, Sección XVI, ZIP Code: 14080, Mexico.Department of Experimental Surgery, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan, Zip code 14080, MexicoOncologic Neurosurgery Unit, Instituto Nacional de Cancerología, Tlalpan, Zip code 14080, MexicoDepartment of Pathology, Hospital Central Sur de Alta Especialidad PEMEX Picacho, Tlalpan, Zip code 14140, MexicoDepartment of Experimental Surgery, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan, Zip code 14080, MexicoDepartment of Experimental Surgery, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan, Zip code 14080, MexicoDepartment of Experimental Surgery, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan, Zip code 14080, MexicoDepartment of Reproductive Biology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan, Zip code 14080, MexicoDepartment of Experimental Surgery, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan, Zip code 14080, MexicoDepartment of Experimental Surgery, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Tlalpan, Zip code 14080, MexicoBackground: Several research studies have been focused on improving the treatment and prognosis of acute spinal cord injury, as part of this initiative we investigated the use of Chetomin to reduce the inflammatory response in this pathology. Methods: An experimental, prospective, cross-sectional study was performed using 42 Wistar rats where we analyzed the effect of Chetomin compared to methylprednisolone administered 1 and 8 h after the spinal cord injury in a murine model. Results: Chetomin administration 8h post-injury decreased IL-6 and VEGF expression; and, and its administration 1h post-injury decreased NF-kB expression. Conclusions: Chetomin has anti-inflammatory effects in acute spinal cord injury, whether these effects are observable with other proinflammatory markers should be investigated.http://www.sciencedirect.com/science/article/pii/S2590139724001455ChetominHIF-1 αIL-6MethylprednisoloneSpinal cord injuryTNF-α |
| spellingShingle | Carlos César Bravo-Reyna Vladimir Miranda-Galván Gervith Reyes-Soto R. Vicuña Jorge Alanis-Mendizabal Manuel Escobar-Valderrama David Arango Claudia J. Bautista Victoria Ramírez Gonzalo Torres-Villalobos Evaluation of the Chetomin effect on histopathological features in a murine acute spinal cord injury model World Neurosurgery: X Chetomin HIF-1 α IL-6 Methylprednisolone Spinal cord injury TNF-α |
| title | Evaluation of the Chetomin effect on histopathological features in a murine acute spinal cord injury model |
| title_full | Evaluation of the Chetomin effect on histopathological features in a murine acute spinal cord injury model |
| title_fullStr | Evaluation of the Chetomin effect on histopathological features in a murine acute spinal cord injury model |
| title_full_unstemmed | Evaluation of the Chetomin effect on histopathological features in a murine acute spinal cord injury model |
| title_short | Evaluation of the Chetomin effect on histopathological features in a murine acute spinal cord injury model |
| title_sort | evaluation of the chetomin effect on histopathological features in a murine acute spinal cord injury model |
| topic | Chetomin HIF-1 α IL-6 Methylprednisolone Spinal cord injury TNF-α |
| url | http://www.sciencedirect.com/science/article/pii/S2590139724001455 |
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