Bifidobacterium fermentation with infant formulas is associated with benefits for gut and brain barrier function
The gut and blood-brain barrier are essential components of the microbiota-gut-brain axis and are influenced by diet, particularly in infancy. Breast milk supports gut and brain barrier function, but infant formulas often lack key protective components. Bifidobacterium is the predominant bacteria in...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-02-01
|
| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464625000039 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823864447229231104 |
|---|---|
| author | Emily G. Knox Paula Sánchez-Díaz Colin Buttimer Sarah-Jane Leigh Klara Vlckova Colin Hill Elaine Kennedy Jonathan O’Regan Seamus McSweeney David Goulding Maria Rodriguez Aburto Caitriona M. O’Driscoll John F. Cryan Eoin Gunnigle Gerard Clarke |
| author_facet | Emily G. Knox Paula Sánchez-Díaz Colin Buttimer Sarah-Jane Leigh Klara Vlckova Colin Hill Elaine Kennedy Jonathan O’Regan Seamus McSweeney David Goulding Maria Rodriguez Aburto Caitriona M. O’Driscoll John F. Cryan Eoin Gunnigle Gerard Clarke |
| author_sort | Emily G. Knox |
| collection | DOAJ |
| description | The gut and blood-brain barrier are essential components of the microbiota-gut-brain axis and are influenced by diet, particularly in infancy. Breast milk supports gut and brain barrier function, but infant formulas often lack key protective components. Bifidobacterium is the predominant bacteria in the infant gut microbiome. Here, we evaluated the impact of four infant formulas fermented with three Bifidobacterium strains, originally isolated from infant stool, on gut and BBB integrity. Cell-free supernatants from these fermentations were exposed to cultures of T84 colonocytes (gut barrier model) or bEnd.3 brain endothelial cells (BBB model), with and without lipopolysaccharide challenge. All three Bifidobacterium strains exhibited protective effects on both gut barrier and BBB integrity with a profile that depended on the infant formula. Taken together, this data indicates that the fermentation products of relevant Bifidobacterium strains with infant formulas may provide protection against barrier disruption. |
| format | Article |
| id | doaj-art-f31ca5a5f1f34bc4ab8d4cd7aeb277e2 |
| institution | Kabale University |
| issn | 1756-4646 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj-art-f31ca5a5f1f34bc4ab8d4cd7aeb277e22025-02-09T04:59:53ZengElsevierJournal of Functional Foods1756-46462025-02-01125106661Bifidobacterium fermentation with infant formulas is associated with benefits for gut and brain barrier functionEmily G. Knox0Paula Sánchez-Díaz1Colin Buttimer2Sarah-Jane Leigh3Klara Vlckova4Colin Hill5Elaine Kennedy6Jonathan O’Regan7Seamus McSweeney8David Goulding9Maria Rodriguez Aburto10Caitriona M. O’Driscoll11John F. Cryan12Eoin Gunnigle13Gerard Clarke14APC Microbiome Ireland, University College Cork, Cork T12 CY82, Ireland; Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork T12 CY82, Ireland; Department of Anatomy and Neuroscience, University College Cork, Cork T12 CY82, Ireland; School of Pharmacy, University College Cork, T12 K8AF, IrelandAPC Microbiome Ireland, University College Cork, Cork T12 CY82, Ireland; Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork T12 CY82, Ireland; Department of Anatomy and Neuroscience, University College Cork, Cork T12 CY82, IrelandAPC Microbiome Ireland, University College Cork, Cork T12 CY82, IrelandAPC Microbiome Ireland, University College Cork, Cork T12 CY82, Ireland; Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork T12 CY82, Ireland; Department of Anatomy and Neuroscience, University College Cork, Cork T12 CY82, IrelandAPC Microbiome Ireland, University College Cork, Cork T12 CY82, Ireland; Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork T12 CY82, Ireland; Department of Anatomy and Neuroscience, University College Cork, Cork T12 CY82, IrelandAPC Microbiome Ireland, University College Cork, Cork T12 CY82, Ireland; School of Microbiology, University College Cork, T12 YT20 Cork, IrelandWyeth Nutrionals Ireland Ltd., Askeaton, Co Limerick, V94 E7P9, IrelandWyeth Nutrionals Ireland Ltd., Askeaton, Co Limerick, V94 E7P9, IrelandWyeth Nutrionals Ireland Ltd., Askeaton, Co Limerick, V94 E7P9, IrelandWyeth Nutrionals Ireland Ltd., Askeaton, Co Limerick, V94 E7P9, IrelandAPC Microbiome Ireland, University College Cork, Cork T12 CY82, Ireland; Department of Anatomy and Neuroscience, University College Cork, Cork T12 CY82, IrelandSchool of Pharmacy, University College Cork, T12 K8AF, IrelandAPC Microbiome Ireland, University College Cork, Cork T12 CY82, Ireland; Department of Anatomy and Neuroscience, University College Cork, Cork T12 CY82, IrelandAPC Microbiome Ireland, University College Cork, Cork T12 CY82, Ireland; Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork T12 CY82, Ireland; Department of Anatomy and Neuroscience, University College Cork, Cork T12 CY82, IrelandAPC Microbiome Ireland, University College Cork, Cork T12 CY82, Ireland; Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork T12 CY82, Ireland; Corresponding author at: APC Microbiome Ireland, University College Cork, Cork T12 CY82, Ireland.The gut and blood-brain barrier are essential components of the microbiota-gut-brain axis and are influenced by diet, particularly in infancy. Breast milk supports gut and brain barrier function, but infant formulas often lack key protective components. Bifidobacterium is the predominant bacteria in the infant gut microbiome. Here, we evaluated the impact of four infant formulas fermented with three Bifidobacterium strains, originally isolated from infant stool, on gut and BBB integrity. Cell-free supernatants from these fermentations were exposed to cultures of T84 colonocytes (gut barrier model) or bEnd.3 brain endothelial cells (BBB model), with and without lipopolysaccharide challenge. All three Bifidobacterium strains exhibited protective effects on both gut barrier and BBB integrity with a profile that depended on the infant formula. Taken together, this data indicates that the fermentation products of relevant Bifidobacterium strains with infant formulas may provide protection against barrier disruption.http://www.sciencedirect.com/science/article/pii/S1756464625000039BifidobacteriumFermentationGut-brain AxisGut barrier functionBrain barrier functionInfant formula |
| spellingShingle | Emily G. Knox Paula Sánchez-Díaz Colin Buttimer Sarah-Jane Leigh Klara Vlckova Colin Hill Elaine Kennedy Jonathan O’Regan Seamus McSweeney David Goulding Maria Rodriguez Aburto Caitriona M. O’Driscoll John F. Cryan Eoin Gunnigle Gerard Clarke Bifidobacterium fermentation with infant formulas is associated with benefits for gut and brain barrier function Journal of Functional Foods Bifidobacterium Fermentation Gut-brain Axis Gut barrier function Brain barrier function Infant formula |
| title | Bifidobacterium fermentation with infant formulas is associated with benefits for gut and brain barrier function |
| title_full | Bifidobacterium fermentation with infant formulas is associated with benefits for gut and brain barrier function |
| title_fullStr | Bifidobacterium fermentation with infant formulas is associated with benefits for gut and brain barrier function |
| title_full_unstemmed | Bifidobacterium fermentation with infant formulas is associated with benefits for gut and brain barrier function |
| title_short | Bifidobacterium fermentation with infant formulas is associated with benefits for gut and brain barrier function |
| title_sort | bifidobacterium fermentation with infant formulas is associated with benefits for gut and brain barrier function |
| topic | Bifidobacterium Fermentation Gut-brain Axis Gut barrier function Brain barrier function Infant formula |
| url | http://www.sciencedirect.com/science/article/pii/S1756464625000039 |
| work_keys_str_mv | AT emilygknox bifidobacteriumfermentationwithinfantformulasisassociatedwithbenefitsforgutandbrainbarrierfunction AT paulasanchezdiaz bifidobacteriumfermentationwithinfantformulasisassociatedwithbenefitsforgutandbrainbarrierfunction AT colinbuttimer bifidobacteriumfermentationwithinfantformulasisassociatedwithbenefitsforgutandbrainbarrierfunction AT sarahjaneleigh bifidobacteriumfermentationwithinfantformulasisassociatedwithbenefitsforgutandbrainbarrierfunction AT klaravlckova bifidobacteriumfermentationwithinfantformulasisassociatedwithbenefitsforgutandbrainbarrierfunction AT colinhill bifidobacteriumfermentationwithinfantformulasisassociatedwithbenefitsforgutandbrainbarrierfunction AT elainekennedy bifidobacteriumfermentationwithinfantformulasisassociatedwithbenefitsforgutandbrainbarrierfunction AT jonathanoregan bifidobacteriumfermentationwithinfantformulasisassociatedwithbenefitsforgutandbrainbarrierfunction AT seamusmcsweeney bifidobacteriumfermentationwithinfantformulasisassociatedwithbenefitsforgutandbrainbarrierfunction AT davidgoulding bifidobacteriumfermentationwithinfantformulasisassociatedwithbenefitsforgutandbrainbarrierfunction AT mariarodriguezaburto bifidobacteriumfermentationwithinfantformulasisassociatedwithbenefitsforgutandbrainbarrierfunction AT caitrionamodriscoll bifidobacteriumfermentationwithinfantformulasisassociatedwithbenefitsforgutandbrainbarrierfunction AT johnfcryan bifidobacteriumfermentationwithinfantformulasisassociatedwithbenefitsforgutandbrainbarrierfunction AT eoingunnigle bifidobacteriumfermentationwithinfantformulasisassociatedwithbenefitsforgutandbrainbarrierfunction AT gerardclarke bifidobacteriumfermentationwithinfantformulasisassociatedwithbenefitsforgutandbrainbarrierfunction |