Differences and analogies in thyroid cancer discovered incidentally or by thyroid-related screening: a multicenter study
Objective: The prevalence of thyroid cancer (TC) has increased worldwide, and an association with metabolic and cardiovascular disorders has been reported. Moreover, an increasing percentage of patients are currently diagnosed incidentally through non-thyroid-related imaging for other clinical condi...
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Bioscientifica
2025-02-01
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| Series: | European Thyroid Journal |
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| Online Access: | https://etj.bioscientifica.com/view/journals/etj/14/1/ETJ-24-0190.xml |
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| author | Laura Croce Rosaria Maddalena Ruggeri Camilla Virili Carlo Cappelli Marsida Teliti Pietro Costa Spyridon Chytiris Antonio Nicocia Francesca Coperchini Maria Flavia Bagaglini Flavia Magri Alfredo Campennì Mario Rotondi |
| author_facet | Laura Croce Rosaria Maddalena Ruggeri Camilla Virili Carlo Cappelli Marsida Teliti Pietro Costa Spyridon Chytiris Antonio Nicocia Francesca Coperchini Maria Flavia Bagaglini Flavia Magri Alfredo Campennì Mario Rotondi |
| author_sort | Laura Croce |
| collection | DOAJ |
| description | Objective: The prevalence of thyroid cancer (TC) has increased worldwide, and an association with metabolic and cardiovascular disorders has been reported. Moreover, an increasing percentage of patients are currently diagnosed incidentally through non-thyroid-related imaging for other clinical conditions. Our aim was to assess the prevalence of thyroid-related disease (TD) versus incidental diagnosis (ID) pre-surgery reasons leading to TC diagnosis and to compare the two groups in terms of clinical characteristics, size and severity of TC at presentation and rate of non-thyroid cancers and cardiovascular/metabolic comorbidities. Design: We performed a retrospective cohort study in three high-volume hospital-based centers for thyroid diseases (Pavia, Latina and Messina) in Italy. Patients: Consecutive patients with TC were included. Measurements: Data on pre-surgery reasons leading to TC diagnosis, age, sex, BMI, presence of cardiometabolic comorbidities and non-thyroid cancer were collected. Results: Among the 327 enrolled subjects, the diagnosis of TC was prompted by thyroid-related reasons in 262 (80.1%, TD group) and incidental in 65 (19.9%, ID group). The ID group patients were more frequently males, significantly older and with a higher BMI than the TD group ones; they had a higher rate of non-thyroidal cancers and cardiovascular/metabolic comorbidities. No significant differences could be observed in terms of TC histotype, cancer size, extrathyroidal extension, lymph node metastases, AJCC staging or American Thyroid Association (ATA) risk stratification. Conclusions: Biological features of TC are similar in the TD and ID groups, but patients in the two groups display significant differences regarding their clinical features. |
| format | Article |
| id | doaj-art-f40591a98dbd4dc497fa441d5aa67642 |
| institution | Kabale University |
| issn | 2235-0802 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | European Thyroid Journal |
| spelling | doaj-art-f40591a98dbd4dc497fa441d5aa676422025-02-09T12:04:06ZengBioscientificaEuropean Thyroid Journal2235-08022025-02-0114110.1530/ETJ-24-01901Differences and analogies in thyroid cancer discovered incidentally or by thyroid-related screening: a multicenter studyLaura Croce0Rosaria Maddalena Ruggeri1Camilla Virili2Carlo Cappelli3Marsida Teliti4Pietro Costa5Spyridon Chytiris6Antonio Nicocia7Francesca Coperchini8Maria Flavia Bagaglini9Flavia Magri10Alfredo Campennì11Mario Rotondi12Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, ItalyDepartment of Human Pathology and Childhood “G. Barresi” (DETEV), University of Messina, Messina, ItalyEndocrinology Section, Department of Medico-Surgical Sciences and Biotechnologies, “Sapienza” University of Rome, Latina, ItalyDepartment of Clinical and Experimental Sciences, SSD Medicina ad indirizzo Endocrino-Metabolico, University of Brescia, ASST Spedali Civili di Brescia, Brescia, ItalyDepartment of Internal Medicine and Therapeutics, University of Pavia, Pavia, ItalyDepartment of Internal Medicine and Therapeutics, University of Pavia, Pavia, ItalyIstituti Clinici Scientifici Maugeri IRCCS, Unit of Endocrinology and Metabolism, Laboratory for Endocrine Disruptors, Pavia, ItalyDepartment of Biomedical and Dental Sciences and Morpho-Functional Imaging, Nuclear Medicine Unit, University of Messina, Messina, ItalyDepartment of Internal Medicine and Therapeutics, University of Pavia, Pavia, ItalyEndocrinology Section, Department of Medico-Surgical Sciences and Biotechnologies, “Sapienza” University of Rome, Latina, ItalyDepartment of Internal Medicine and Therapeutics, University of Pavia, Pavia, ItalyDepartment of Biomedical and Dental Sciences and Morpho-Functional Imaging, Nuclear Medicine Unit, University of Messina, Messina, ItalyDepartment of Internal Medicine and Therapeutics, University of Pavia, Pavia, ItalyObjective: The prevalence of thyroid cancer (TC) has increased worldwide, and an association with metabolic and cardiovascular disorders has been reported. Moreover, an increasing percentage of patients are currently diagnosed incidentally through non-thyroid-related imaging for other clinical conditions. Our aim was to assess the prevalence of thyroid-related disease (TD) versus incidental diagnosis (ID) pre-surgery reasons leading to TC diagnosis and to compare the two groups in terms of clinical characteristics, size and severity of TC at presentation and rate of non-thyroid cancers and cardiovascular/metabolic comorbidities. Design: We performed a retrospective cohort study in three high-volume hospital-based centers for thyroid diseases (Pavia, Latina and Messina) in Italy. Patients: Consecutive patients with TC were included. Measurements: Data on pre-surgery reasons leading to TC diagnosis, age, sex, BMI, presence of cardiometabolic comorbidities and non-thyroid cancer were collected. Results: Among the 327 enrolled subjects, the diagnosis of TC was prompted by thyroid-related reasons in 262 (80.1%, TD group) and incidental in 65 (19.9%, ID group). The ID group patients were more frequently males, significantly older and with a higher BMI than the TD group ones; they had a higher rate of non-thyroidal cancers and cardiovascular/metabolic comorbidities. No significant differences could be observed in terms of TC histotype, cancer size, extrathyroidal extension, lymph node metastases, AJCC staging or American Thyroid Association (ATA) risk stratification. Conclusions: Biological features of TC are similar in the TD and ID groups, but patients in the two groups display significant differences regarding their clinical features.https://etj.bioscientifica.com/view/journals/etj/14/1/ETJ-24-0190.xmlthyroid cancercardiovascular diseasesmetabolic syndromeincidental diagnosisthyroid ultrasound |
| spellingShingle | Laura Croce Rosaria Maddalena Ruggeri Camilla Virili Carlo Cappelli Marsida Teliti Pietro Costa Spyridon Chytiris Antonio Nicocia Francesca Coperchini Maria Flavia Bagaglini Flavia Magri Alfredo Campennì Mario Rotondi Differences and analogies in thyroid cancer discovered incidentally or by thyroid-related screening: a multicenter study European Thyroid Journal thyroid cancer cardiovascular diseases metabolic syndrome incidental diagnosis thyroid ultrasound |
| title | Differences and analogies in thyroid cancer discovered incidentally or by thyroid-related screening: a multicenter study |
| title_full | Differences and analogies in thyroid cancer discovered incidentally or by thyroid-related screening: a multicenter study |
| title_fullStr | Differences and analogies in thyroid cancer discovered incidentally or by thyroid-related screening: a multicenter study |
| title_full_unstemmed | Differences and analogies in thyroid cancer discovered incidentally or by thyroid-related screening: a multicenter study |
| title_short | Differences and analogies in thyroid cancer discovered incidentally or by thyroid-related screening: a multicenter study |
| title_sort | differences and analogies in thyroid cancer discovered incidentally or by thyroid related screening a multicenter study |
| topic | thyroid cancer cardiovascular diseases metabolic syndrome incidental diagnosis thyroid ultrasound |
| url | https://etj.bioscientifica.com/view/journals/etj/14/1/ETJ-24-0190.xml |
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