Repetitive stability study of remdesivir/cyclodextrin complex on the international space station
Abstract Stability assessment of drugs in space is particularly important for future missions. In space there are multiple factors, such as the variability of the conditions (radiation, microgravity, vacuum etc.) that could affect the reliability and reproducibility of the data. Therefore, we invest...
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Nature Portfolio
2025-02-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-81428-5 |
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| author | György Dormán Balázs Buchholcz István Puskás Pál Szabó Erzsébet Varga Lajos Szente György M. Keserű Ferenc Darvas |
| author_facet | György Dormán Balázs Buchholcz István Puskás Pál Szabó Erzsébet Varga Lajos Szente György M. Keserű Ferenc Darvas |
| author_sort | György Dormán |
| collection | DOAJ |
| description | Abstract Stability assessment of drugs in space is particularly important for future missions. In space there are multiple factors, such as the variability of the conditions (radiation, microgravity, vacuum etc.) that could affect the reliability and reproducibility of the data. Therefore, we investigated the stability of an anti-Covid drug formulation, Remdesivir (RDV) sulfobutylether-beta-cyclodextrin (SBECD) complex, in two separate flight experiments on the International Space Station (ISS). While HPLC/MS studies revealed no degradation of the cyclodextrin excipient in any of the samples investigated in both missions, RDV purity analysis of the RDV/SBECD complex after the first mission revealed different stabilities and altered degradation in space and on Earth. This latter interesting finding was not supported by the second mission, where no differences in the drug stabilities were identified. This anomaly highlighted the importance of standardization together with increased control of the variable parameters during the entire space missions and the terrestrial control experiments. |
| format | Article |
| id | doaj-art-f460d8fcace14e5f936bdb5cfb58eab3 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-f460d8fcace14e5f936bdb5cfb58eab32025-02-09T12:30:33ZengNature PortfolioScientific Reports2045-23222025-02-0115111010.1038/s41598-024-81428-5Repetitive stability study of remdesivir/cyclodextrin complex on the international space stationGyörgy Dormán0Balázs Buchholcz1István Puskás2Pál Szabó3Erzsébet Varga4Lajos Szente5György M. Keserű6Ferenc Darvas7Innostudio, Inc.Innostudio, Inc.Cyclolab Cyclodextrin Research & Development Laboratory LtdResearch Centre for Natural Science and National Drug Research and Development LaboratoryCyclolab Cyclodextrin Research & Development Laboratory LtdCyclolab Cyclodextrin Research & Development Laboratory LtdResearch Centre for Natural Science and National Drug Research and Development LaboratoryInnostudio, Inc.Abstract Stability assessment of drugs in space is particularly important for future missions. In space there are multiple factors, such as the variability of the conditions (radiation, microgravity, vacuum etc.) that could affect the reliability and reproducibility of the data. Therefore, we investigated the stability of an anti-Covid drug formulation, Remdesivir (RDV) sulfobutylether-beta-cyclodextrin (SBECD) complex, in two separate flight experiments on the International Space Station (ISS). While HPLC/MS studies revealed no degradation of the cyclodextrin excipient in any of the samples investigated in both missions, RDV purity analysis of the RDV/SBECD complex after the first mission revealed different stabilities and altered degradation in space and on Earth. This latter interesting finding was not supported by the second mission, where no differences in the drug stabilities were identified. This anomaly highlighted the importance of standardization together with increased control of the variable parameters during the entire space missions and the terrestrial control experiments.https://doi.org/10.1038/s41598-024-81428-5Remdesivir sulfobutylether-beta-cyclodextrinIn-space drug stabilitySpace medicinal chemistrySpace environmentChemical degradationReproducibility |
| spellingShingle | György Dormán Balázs Buchholcz István Puskás Pál Szabó Erzsébet Varga Lajos Szente György M. Keserű Ferenc Darvas Repetitive stability study of remdesivir/cyclodextrin complex on the international space station Scientific Reports Remdesivir sulfobutylether-beta-cyclodextrin In-space drug stability Space medicinal chemistry Space environment Chemical degradation Reproducibility |
| title | Repetitive stability study of remdesivir/cyclodextrin complex on the international space station |
| title_full | Repetitive stability study of remdesivir/cyclodextrin complex on the international space station |
| title_fullStr | Repetitive stability study of remdesivir/cyclodextrin complex on the international space station |
| title_full_unstemmed | Repetitive stability study of remdesivir/cyclodextrin complex on the international space station |
| title_short | Repetitive stability study of remdesivir/cyclodextrin complex on the international space station |
| title_sort | repetitive stability study of remdesivir cyclodextrin complex on the international space station |
| topic | Remdesivir sulfobutylether-beta-cyclodextrin In-space drug stability Space medicinal chemistry Space environment Chemical degradation Reproducibility |
| url | https://doi.org/10.1038/s41598-024-81428-5 |
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