Genetic interaction between oxidative stress and body mass index in a Spanish population
Oxidative stress may act as a contributing factor in the development of an elevated body mass index (BMI). Oxidative stress has the potential to modulate genetic activity at various levels, including gene transcription and protein function regulation. Nevertheless, the interplay between genetic vari...
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| Language: | English |
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Elsevier
2025-03-01
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| Series: | Redox Biology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213231725000448 |
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| author | Francisco Lara-Hernández Rebeca Melero María Elena Quiroz-Rodríguez Celeste Moya-Valera Mariana de Jesús Gallardo-Espinoza Luis Álvarez Ingrid Lizeth Valarezo-Torres Laisa Briongos-Figuero Jessica Abadía-Otero Francisco Javier Mena-Martin Guillermo Saez Josep Redon Juan-Carlos Martín-Escudero Ana-Bárbara García-García Guillermo Ayala Felipe Javier Chaves |
| author_facet | Francisco Lara-Hernández Rebeca Melero María Elena Quiroz-Rodríguez Celeste Moya-Valera Mariana de Jesús Gallardo-Espinoza Luis Álvarez Ingrid Lizeth Valarezo-Torres Laisa Briongos-Figuero Jessica Abadía-Otero Francisco Javier Mena-Martin Guillermo Saez Josep Redon Juan-Carlos Martín-Escudero Ana-Bárbara García-García Guillermo Ayala Felipe Javier Chaves |
| author_sort | Francisco Lara-Hernández |
| collection | DOAJ |
| description | Oxidative stress may act as a contributing factor in the development of an elevated body mass index (BMI). Oxidative stress has the potential to modulate genetic activity at various levels, including gene transcription and protein function regulation. Nevertheless, the interplay between genetic variants and oxidative stress in relation to BMI remains to be elucidated. Based on this premise, we studied the potential association between 723 single-nucleotide polymorphisms (SNPs) located within a set of 212 genes and both BMI and oxidative stress parameters in 1502 adults from the general Spanish population (Hortega Study). Oxidative stress parameters measured included malondialdehyde (MDA) levels, 8-oxo-2′-deoxyguanosine (8-oxo-dG) levels and oxidised/reduced glutathione ratio (GSSG/GSH). We also examined the potential impact of the interaction between these SNPs and oxidative stress levels on BMI. The genes selected regulate several key biological processes, including obesity, blood pressure, inflammation, lipid metabolism and redox homeostasis. Our findings indicate a robust association between specific genes and both BMI and oxidative stress parameters. Significant BMI-related interactions between genes and oxidative stress parameters were identified, which have a multifactorial impact on oxidative stress modulation and on BMI. SNPs identified in genes such as NPPA, CPT1A, DDIT3, NOX and IL6ST were significantly associated with all oxidative stress parameters analysed, indicating a substantial influence on BMI modulation. The results provide compelling evidence of a significant relationship between oxidative stress levels and genetic background. Our data provide new insights into BMI modulation by oxidative stress levels, highlighting a role for TNF as a key player in the interrelation of oxidative stress and BMI. |
| format | Article |
| id | doaj-art-f48e73b25e8e4043be37842a12ee4986 |
| institution | Kabale University |
| issn | 2213-2317 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Redox Biology |
| spelling | doaj-art-f48e73b25e8e4043be37842a12ee49862025-02-10T04:34:21ZengElsevierRedox Biology2213-23172025-03-0180103531Genetic interaction between oxidative stress and body mass index in a Spanish populationFrancisco Lara-Hernández0Rebeca Melero1María Elena Quiroz-Rodríguez2Celeste Moya-Valera3Mariana de Jesús Gallardo-Espinoza4Luis Álvarez5Ingrid Lizeth Valarezo-Torres6Laisa Briongos-Figuero7Jessica Abadía-Otero8Francisco Javier Mena-Martin9Guillermo Saez10Josep Redon11Juan-Carlos Martín-Escudero12Ana-Bárbara García-García13Guillermo Ayala14Felipe Javier Chaves15Genomics and Diabetes Unit. INCLIVA Biomedical Research Institute, 46010, Valencia, SpainGenomics and Diabetes Unit. INCLIVA Biomedical Research Institute, 46010, Valencia, SpainGenomics and Diabetes Unit. INCLIVA Biomedical Research Institute, 46010, Valencia, SpainGenomics and Diabetes Unit. INCLIVA Biomedical Research Institute, 46010, Valencia, SpainGenomics and Diabetes Unit. INCLIVA Biomedical Research Institute, 46010, Valencia, SpainGenomics and Diabetes Unit. INCLIVA Biomedical Research Institute, 46010, Valencia, SpainGenomics and Diabetes Unit. INCLIVA Biomedical Research Institute, 46010, Valencia, SpainInternal Medicine Service. Rio Hortega University Hospital, 47012, Valladolid, SpainInternal Medicine Service. Rio Hortega University Hospital, 47012, Valladolid, SpainInternal Medicine Service. Rio Hortega University Hospital, 47012, Valladolid, SpainDepartment of Biochemistry and Molecular Biology, Faculty of Medicine and Odontology. University of Valencia, 46010, Valencia, Spain; Service of Clinical Analysis. University Hospital Dr. Peset-FISABIO, SpainCardiometabolic Renal Risk Research Group, INCLIVA Biomedical Research Institute, University of Valencia, 46010, Valencia, Spain; CIBEROBN, ISCIII, 28029, Madrid, SpainInternal Medicine Service. Rio Hortega University Hospital, 47012, Valladolid, Spain; Department of Medicine, Faculty of Medicine, University of Valladolid, 47002, Valladolid, SpainGenomics and Diabetes Unit. INCLIVA Biomedical Research Institute, 46010, Valencia, Spain; CIBERDEM, ISCIII, 28029, Madrid, Spain; Corresponding author. Menéndez Pelayo 4 acc, Valencia, 46010, Spain.Department of Statistics and Operation Research, University of Valencia, Burjassot, 46100, Valencia, SpainGenomics and Diabetes Unit. INCLIVA Biomedical Research Institute, 46010, Valencia, Spain; CIBERDEM, ISCIII, 28029, Madrid, SpainOxidative stress may act as a contributing factor in the development of an elevated body mass index (BMI). Oxidative stress has the potential to modulate genetic activity at various levels, including gene transcription and protein function regulation. Nevertheless, the interplay between genetic variants and oxidative stress in relation to BMI remains to be elucidated. Based on this premise, we studied the potential association between 723 single-nucleotide polymorphisms (SNPs) located within a set of 212 genes and both BMI and oxidative stress parameters in 1502 adults from the general Spanish population (Hortega Study). Oxidative stress parameters measured included malondialdehyde (MDA) levels, 8-oxo-2′-deoxyguanosine (8-oxo-dG) levels and oxidised/reduced glutathione ratio (GSSG/GSH). We also examined the potential impact of the interaction between these SNPs and oxidative stress levels on BMI. The genes selected regulate several key biological processes, including obesity, blood pressure, inflammation, lipid metabolism and redox homeostasis. Our findings indicate a robust association between specific genes and both BMI and oxidative stress parameters. Significant BMI-related interactions between genes and oxidative stress parameters were identified, which have a multifactorial impact on oxidative stress modulation and on BMI. SNPs identified in genes such as NPPA, CPT1A, DDIT3, NOX and IL6ST were significantly associated with all oxidative stress parameters analysed, indicating a substantial influence on BMI modulation. The results provide compelling evidence of a significant relationship between oxidative stress levels and genetic background. Our data provide new insights into BMI modulation by oxidative stress levels, highlighting a role for TNF as a key player in the interrelation of oxidative stress and BMI.http://www.sciencedirect.com/science/article/pii/S2213231725000448Body mass indexOxidative stressSNPLinear regression modelInteractionLipid peroxidation |
| spellingShingle | Francisco Lara-Hernández Rebeca Melero María Elena Quiroz-Rodríguez Celeste Moya-Valera Mariana de Jesús Gallardo-Espinoza Luis Álvarez Ingrid Lizeth Valarezo-Torres Laisa Briongos-Figuero Jessica Abadía-Otero Francisco Javier Mena-Martin Guillermo Saez Josep Redon Juan-Carlos Martín-Escudero Ana-Bárbara García-García Guillermo Ayala Felipe Javier Chaves Genetic interaction between oxidative stress and body mass index in a Spanish population Redox Biology Body mass index Oxidative stress SNP Linear regression model Interaction Lipid peroxidation |
| title | Genetic interaction between oxidative stress and body mass index in a Spanish population |
| title_full | Genetic interaction between oxidative stress and body mass index in a Spanish population |
| title_fullStr | Genetic interaction between oxidative stress and body mass index in a Spanish population |
| title_full_unstemmed | Genetic interaction between oxidative stress and body mass index in a Spanish population |
| title_short | Genetic interaction between oxidative stress and body mass index in a Spanish population |
| title_sort | genetic interaction between oxidative stress and body mass index in a spanish population |
| topic | Body mass index Oxidative stress SNP Linear regression model Interaction Lipid peroxidation |
| url | http://www.sciencedirect.com/science/article/pii/S2213231725000448 |
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