Optic Nerve Sheath Diameter in Predicting the Neurological Outcomes of Cardiac Arrest Survivors: A Systematic Review and Meta-analysis
Introduction: Previous studies have investigated different methods for estimating neurological outcomes after cardiac arrest. However, there is still much uncertainty about using optic nerve sheath diameter (ONSD) measurement as an indirect method for predicting neurological outcomes following card...
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Shahid Beheshti University of Medical Sciences
2025-01-01
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| Series: | Archives of Academic Emergency Medicine |
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| Online Access: | https://journals.sbmu.ac.ir/aaem/index.php/AAEM/article/view/2486 |
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| author | Parisa Jafari Khouzani Erfan Rahmani Mehdi Rezaei Sasan Pohrbagher Benam Atousa Moghadam Fard Reza Amani-Beni Maziar Daneshvar Faezeh Jalayer Sarnaghy Naghme Masoomi Goodarzi Ramila Abedi Azar Amirhossein Mirbolook Peyman Bashghareh Elham Bibak Babak Goodarzi Zahra Salarinezhad Reza Zahedpasha Marzieh Hajizaman Negar Pourhossein Rahmani Azam Darvishi Alireza Hadizadeh Fatemeh Zandi Ashkan Azizi Armin Naderi Sepideh Shah Hosseini Asie Sanjary Mozhdeh Mohammadi Virsoudi Habibollah Afshang Seyedsaber Mirabdali Navid Fathalian Pouria Momeni Mahsan Valizade Fateme Nozari Hamed Ghorbani Sanam Mohammadzadeh Seyed Kiavash Sajadi Azam Abdollahi Mehrdad Farrokhi |
| author_facet | Parisa Jafari Khouzani Erfan Rahmani Mehdi Rezaei Sasan Pohrbagher Benam Atousa Moghadam Fard Reza Amani-Beni Maziar Daneshvar Faezeh Jalayer Sarnaghy Naghme Masoomi Goodarzi Ramila Abedi Azar Amirhossein Mirbolook Peyman Bashghareh Elham Bibak Babak Goodarzi Zahra Salarinezhad Reza Zahedpasha Marzieh Hajizaman Negar Pourhossein Rahmani Azam Darvishi Alireza Hadizadeh Fatemeh Zandi Ashkan Azizi Armin Naderi Sepideh Shah Hosseini Asie Sanjary Mozhdeh Mohammadi Virsoudi Habibollah Afshang Seyedsaber Mirabdali Navid Fathalian Pouria Momeni Mahsan Valizade Fateme Nozari Hamed Ghorbani Sanam Mohammadzadeh Seyed Kiavash Sajadi Azam Abdollahi Mehrdad Farrokhi |
| author_sort | Parisa Jafari Khouzani |
| collection | DOAJ |
| description |
Introduction: Previous studies have investigated different methods for estimating neurological outcomes after cardiac arrest. However, there is still much uncertainty about using optic nerve sheath diameter (ONSD) measurement as an indirect method for predicting neurological outcomes following cardiac arrest. In this meta-analysis, we aimed to investigate the value of ONSD for predicting the neurological outcomes of cardiac arrest survivors.
Methods: We comprehensively performed a systematic search in three main electronic databases, including Scopus, Medline, and Web of Science Cochrane, from inception to August 2024. Based on the heterogeneity evaluation results, fixed or random effects models were used to estimate the pooled diagnostic parameters. Meta-regressions were performed for subgroup analysis.
Results: The pooled sensitivity and specificity of ONSD for predicting the neurological outcomes were 0.56 (95% CI, 0.35–0.74) and 0.92 (95% CI, 0.85–0.96), respectively. Meta-regression revealed that as the cutoff level of ONSD increases, the sensitivity significantly decreases (P < 0.01), while the specificity significantly increases (P = 0.01). Furthermore, meta-regression analysis revealed that ONSD measurement using CT scans is significantly associated with lower sensitivity and higher specificity compared to ultrasound (P = 0.009 and P = 0.01).
Conclusion: Our meta-analysis showed that ONSD has low sensitivity and high specificity for predicting neurological outcomes in survivors of cardiac arrest. However, since the cut-off values and methods of ONSD measurement affect its predictive performance, further studies will be required to standardize these factors to achieve optimal predictive parameters.
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| format | Article |
| id | doaj-art-f4928d082fda44d281b15412f935d97d |
| institution | Kabale University |
| issn | 2645-4904 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Shahid Beheshti University of Medical Sciences |
| record_format | Article |
| series | Archives of Academic Emergency Medicine |
| spelling | doaj-art-f4928d082fda44d281b15412f935d97d2025-02-11T20:47:50ZengShahid Beheshti University of Medical SciencesArchives of Academic Emergency Medicine2645-49042025-01-0113110.22037/aaemj.v13i1.2486Optic Nerve Sheath Diameter in Predicting the Neurological Outcomes of Cardiac Arrest Survivors: A Systematic Review and Meta-analysis Parisa Jafari KhouzaniErfan RahmaniMehdi RezaeiSasan Pohrbagher BenamAtousa Moghadam FardReza Amani-BeniMaziar DaneshvarFaezeh Jalayer SarnaghyNaghme Masoomi GoodarziRamila Abedi AzarAmirhossein MirbolookPeyman BashgharehElham BibakBabak GoodarziZahra SalarinezhadReza ZahedpashaMarzieh HajizamanNegar Pourhossein RahmaniAzam DarvishiAlireza HadizadehFatemeh ZandiAshkan AziziArmin NaderiSepideh Shah HosseiniAsie SanjaryMozhdeh Mohammadi VirsoudiHabibollah AfshangSeyedsaber MirabdaliNavid FathalianPouria MomeniMahsan ValizadeFateme NozariHamed GhorbaniSanam MohammadzadehSeyed Kiavash SajadiAzam AbdollahiMehrdad Farrokhi Introduction: Previous studies have investigated different methods for estimating neurological outcomes after cardiac arrest. However, there is still much uncertainty about using optic nerve sheath diameter (ONSD) measurement as an indirect method for predicting neurological outcomes following cardiac arrest. In this meta-analysis, we aimed to investigate the value of ONSD for predicting the neurological outcomes of cardiac arrest survivors. Methods: We comprehensively performed a systematic search in three main electronic databases, including Scopus, Medline, and Web of Science Cochrane, from inception to August 2024. Based on the heterogeneity evaluation results, fixed or random effects models were used to estimate the pooled diagnostic parameters. Meta-regressions were performed for subgroup analysis. Results: The pooled sensitivity and specificity of ONSD for predicting the neurological outcomes were 0.56 (95% CI, 0.35–0.74) and 0.92 (95% CI, 0.85–0.96), respectively. Meta-regression revealed that as the cutoff level of ONSD increases, the sensitivity significantly decreases (P < 0.01), while the specificity significantly increases (P = 0.01). Furthermore, meta-regression analysis revealed that ONSD measurement using CT scans is significantly associated with lower sensitivity and higher specificity compared to ultrasound (P = 0.009 and P = 0.01). Conclusion: Our meta-analysis showed that ONSD has low sensitivity and high specificity for predicting neurological outcomes in survivors of cardiac arrest. However, since the cut-off values and methods of ONSD measurement affect its predictive performance, further studies will be required to standardize these factors to achieve optimal predictive parameters. https://journals.sbmu.ac.ir/aaem/index.php/AAEM/article/view/2486Diagnostic TechniquesNeurological; Heart ArrestMeta-analysisOptic NervePrognosis |
| spellingShingle | Parisa Jafari Khouzani Erfan Rahmani Mehdi Rezaei Sasan Pohrbagher Benam Atousa Moghadam Fard Reza Amani-Beni Maziar Daneshvar Faezeh Jalayer Sarnaghy Naghme Masoomi Goodarzi Ramila Abedi Azar Amirhossein Mirbolook Peyman Bashghareh Elham Bibak Babak Goodarzi Zahra Salarinezhad Reza Zahedpasha Marzieh Hajizaman Negar Pourhossein Rahmani Azam Darvishi Alireza Hadizadeh Fatemeh Zandi Ashkan Azizi Armin Naderi Sepideh Shah Hosseini Asie Sanjary Mozhdeh Mohammadi Virsoudi Habibollah Afshang Seyedsaber Mirabdali Navid Fathalian Pouria Momeni Mahsan Valizade Fateme Nozari Hamed Ghorbani Sanam Mohammadzadeh Seyed Kiavash Sajadi Azam Abdollahi Mehrdad Farrokhi Optic Nerve Sheath Diameter in Predicting the Neurological Outcomes of Cardiac Arrest Survivors: A Systematic Review and Meta-analysis Archives of Academic Emergency Medicine Diagnostic Techniques Neurological; Heart Arrest Meta-analysis Optic Nerve Prognosis |
| title | Optic Nerve Sheath Diameter in Predicting the Neurological Outcomes of Cardiac Arrest Survivors: A Systematic Review and Meta-analysis |
| title_full | Optic Nerve Sheath Diameter in Predicting the Neurological Outcomes of Cardiac Arrest Survivors: A Systematic Review and Meta-analysis |
| title_fullStr | Optic Nerve Sheath Diameter in Predicting the Neurological Outcomes of Cardiac Arrest Survivors: A Systematic Review and Meta-analysis |
| title_full_unstemmed | Optic Nerve Sheath Diameter in Predicting the Neurological Outcomes of Cardiac Arrest Survivors: A Systematic Review and Meta-analysis |
| title_short | Optic Nerve Sheath Diameter in Predicting the Neurological Outcomes of Cardiac Arrest Survivors: A Systematic Review and Meta-analysis |
| title_sort | optic nerve sheath diameter in predicting the neurological outcomes of cardiac arrest survivors a systematic review and meta analysis |
| topic | Diagnostic Techniques Neurological; Heart Arrest Meta-analysis Optic Nerve Prognosis |
| url | https://journals.sbmu.ac.ir/aaem/index.php/AAEM/article/view/2486 |
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