Fecal Microbiota Transplantation: A Systematic Review of Therapeutic Potential, Preparation Techniques, and Delivery Methods Across Medical Conditions
Fecal microbiota transplantation (FMT) is revolutionizing the treatment of gastrointestinal disorders by leveraging the gut microbiome in innovative ways. This systematic review evaluates the clinical effectiveness and safety of FMT across various medical conditions, offering insights into its ther...
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| Format: | Article |
| Language: | English |
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Sulaimani Polytechnic University
2024-11-01
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| Series: | Kurdistan Journal of Applied Research |
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| Online Access: | https://kjar.spu.edu.iq/index.php/kjar/article/view/952 |
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| author | Syamand Ahmed Qadir Qausar Hamed ALKaisy Abdulbasit F. Hasan Farhang Hameed Awlqadr Ammar B. Altemimi Aryan Mahmood Faraj Angelo Maria Giuffrè Mohammed N. Saeed Sherzad Rasul Abdalla |
| author_facet | Syamand Ahmed Qadir Qausar Hamed ALKaisy Abdulbasit F. Hasan Farhang Hameed Awlqadr Ammar B. Altemimi Aryan Mahmood Faraj Angelo Maria Giuffrè Mohammed N. Saeed Sherzad Rasul Abdalla |
| author_sort | Syamand Ahmed Qadir |
| collection | DOAJ |
| description |
Fecal microbiota transplantation (FMT) is revolutionizing the treatment of gastrointestinal disorders by leveraging the gut microbiome in innovative ways. This systematic review evaluates the clinical effectiveness and safety of FMT across various medical conditions, offering insights into its therapeutic potential and limitations. A comprehensive search of PubMed, Web of Science, Scopus, Embase, and ClinicalTrials.gov from January 2000 to December 2023 identified 97 relevant studies on FMT's efficacy, safety, and microbiome changes after eliminating duplicates. FMT has demonstrated high success rates, particularly in treating recurrent and refractory Clostridium difficile infections (CDI), with up to 90% effectiveness, establishing it as a primary treatment for antibiotic-resistant cases. FMT’s applications are expanding to inflammatory bowel diseases (IBD), including ulcerative colitis and Crohn's disease, as well as metabolic disorders and neuropsychiatric conditions. Remission rates for IBD range from 37-45%, with outcomes influenced by donor characteristics, stool preparation, and disease subtype. with mild, self-limiting side effects such as transient diarrhea and abdominal cramping. However, rare serious adverse events underscore the need for rigorous donor screening and standardized preparation protocols to mitigate risks. FMT’s ability to restore healthy gut flora highlights its promise in both gastrointestinal and systemic disease management. However, further research is essential to establish optimized procedures, standardized guidelines, and long-term safety data to facilitate its integration into mainstream medical practice.
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| format | Article |
| id | doaj-art-f4c1447ad44e4eecb76f007890a3af73 |
| institution | Kabale University |
| issn | 2411-7684 2411-7706 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Sulaimani Polytechnic University |
| record_format | Article |
| series | Kurdistan Journal of Applied Research |
| spelling | doaj-art-f4c1447ad44e4eecb76f007890a3af732025-02-09T20:59:28ZengSulaimani Polytechnic UniversityKurdistan Journal of Applied Research2411-76842411-77062024-11-019210.24017/science.2024.2.6Fecal Microbiota Transplantation: A Systematic Review of Therapeutic Potential, Preparation Techniques, and Delivery Methods Across Medical ConditionsSyamand Ahmed Qadir 0https://orcid.org/0000-0002-6498-2643Qausar Hamed ALKaisy 1https://orcid.org/0000-0003-2039-6551Abdulbasit F. Hasan2https://orcid.org/0000-0002-8041-3360Farhang Hameed Awlqadr3https://orcid.org/0000-0002-1737-5920Ammar B. Altemimi4https://orcid.org/0000-0001-7750-5988Aryan Mahmood Faraj 5https://orcid.org/0000-0002-7229-3717Angelo Maria Giuffrè 6https://orcid.org/0000-0002-4663-8056Mohammed N. Saeed7https://orcid.org/0009-0003-6968-4252Sherzad Rasul Abdalla 8https://orcid.org/0009-0002-1324-6774Medical Laboratory Techniques Department, Halabja Technical Institute, Research center, Sulaimani Polytechnic University, Sulaymaniyah, IraqDepartment of Dairy Science and Technology, College of Food Sciences, University of AL-Qasim Green, Al Qasim, IraqDepartment of Food Science, College of Agriculture, University of Basrah, Basrah, IraqFood Science and Quality Control, Halabja Technical College Applied Science, Sulaimani Polytechnic University, Sulaymaniyah, IraqDepartment of Food Science, College of Agriculture, University of Basrah, Basrah, IraqMedical Laboratory Science Department, Halabja Technical College of Applied Sciences, Sulaimani Polytechnic University Sulaymaniyah, IraqDepartment Agraria, University of Studies Mediterranea of Reggio Calabria, Reggio Calabria, ItalyDepartment of Nutritional Analysis and Health, Kifri Technical college, Garmian Polytechnic University, Sulaymaniyah , IraqMedical Laboratory Techniques Department, Halabja Technical Institute, Research center, Sulaimani Polytechnic University, Sulaymaniyah, Iraq Fecal microbiota transplantation (FMT) is revolutionizing the treatment of gastrointestinal disorders by leveraging the gut microbiome in innovative ways. This systematic review evaluates the clinical effectiveness and safety of FMT across various medical conditions, offering insights into its therapeutic potential and limitations. A comprehensive search of PubMed, Web of Science, Scopus, Embase, and ClinicalTrials.gov from January 2000 to December 2023 identified 97 relevant studies on FMT's efficacy, safety, and microbiome changes after eliminating duplicates. FMT has demonstrated high success rates, particularly in treating recurrent and refractory Clostridium difficile infections (CDI), with up to 90% effectiveness, establishing it as a primary treatment for antibiotic-resistant cases. FMT’s applications are expanding to inflammatory bowel diseases (IBD), including ulcerative colitis and Crohn's disease, as well as metabolic disorders and neuropsychiatric conditions. Remission rates for IBD range from 37-45%, with outcomes influenced by donor characteristics, stool preparation, and disease subtype. with mild, self-limiting side effects such as transient diarrhea and abdominal cramping. However, rare serious adverse events underscore the need for rigorous donor screening and standardized preparation protocols to mitigate risks. FMT’s ability to restore healthy gut flora highlights its promise in both gastrointestinal and systemic disease management. However, further research is essential to establish optimized procedures, standardized guidelines, and long-term safety data to facilitate its integration into mainstream medical practice. https://kjar.spu.edu.iq/index.php/kjar/article/view/952Fecal Microbiota Transplantation (FMT)Therapy Gut Microbiome systematic review and Dysbiosis |
| spellingShingle | Syamand Ahmed Qadir Qausar Hamed ALKaisy Abdulbasit F. Hasan Farhang Hameed Awlqadr Ammar B. Altemimi Aryan Mahmood Faraj Angelo Maria Giuffrè Mohammed N. Saeed Sherzad Rasul Abdalla Fecal Microbiota Transplantation: A Systematic Review of Therapeutic Potential, Preparation Techniques, and Delivery Methods Across Medical Conditions Kurdistan Journal of Applied Research Fecal Microbiota Transplantation (FMT) Therapy Gut Microbiome systematic review and Dysbiosis |
| title | Fecal Microbiota Transplantation: A Systematic Review of Therapeutic Potential, Preparation Techniques, and Delivery Methods Across Medical Conditions |
| title_full | Fecal Microbiota Transplantation: A Systematic Review of Therapeutic Potential, Preparation Techniques, and Delivery Methods Across Medical Conditions |
| title_fullStr | Fecal Microbiota Transplantation: A Systematic Review of Therapeutic Potential, Preparation Techniques, and Delivery Methods Across Medical Conditions |
| title_full_unstemmed | Fecal Microbiota Transplantation: A Systematic Review of Therapeutic Potential, Preparation Techniques, and Delivery Methods Across Medical Conditions |
| title_short | Fecal Microbiota Transplantation: A Systematic Review of Therapeutic Potential, Preparation Techniques, and Delivery Methods Across Medical Conditions |
| title_sort | fecal microbiota transplantation a systematic review of therapeutic potential preparation techniques and delivery methods across medical conditions |
| topic | Fecal Microbiota Transplantation (FMT) Therapy Gut Microbiome systematic review and Dysbiosis |
| url | https://kjar.spu.edu.iq/index.php/kjar/article/view/952 |
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