Positron emission tomography molecular imaging for pathological visualization in multiple system atrophy
Multiple system atrophy (MSA) is a complex, heterogeneous neurodegenerative disorder characterized by a multifaceted pathogenesis. Its key pathological hallmark is the abnormal aggregation of α-synuclein, which triggers neuroinflammation, disrupts both dopaminergic and non-dopaminergic systems, and...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Neurobiology of Disease |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996125000440 |
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| author | La Dong Rui Zhou Jinyun Zhou Ke Liu Chentao Jin Jing Wang Chenxi Xue Mei Tian Hong Zhang Yan Zhong |
| author_facet | La Dong Rui Zhou Jinyun Zhou Ke Liu Chentao Jin Jing Wang Chenxi Xue Mei Tian Hong Zhang Yan Zhong |
| author_sort | La Dong |
| collection | DOAJ |
| description | Multiple system atrophy (MSA) is a complex, heterogeneous neurodegenerative disorder characterized by a multifaceted pathogenesis. Its key pathological hallmark is the abnormal aggregation of α-synuclein, which triggers neuroinflammation, disrupts both dopaminergic and non-dopaminergic systems, and results in metabolic abnormalities in the brain. Positron emission tomography (PET) is a non-invasive technique that enables the visualization, characterization, and quantification of these pathological processes from diverse perspectives using radiolabeled agents. PET imaging of molecular events provides valuable insights into the underlying pathomechanisms of MSA and holds significant promise for the development of imaging biomarkers, which could greatly improve disease assessment and management. In this review, we focused on the pathological mechanisms of MSA, summarized relevant targets and radiopharmaceuticals, and discussed the clinical applications and future perspectives of PET molecular imaging in MSA. |
| format | Article |
| id | doaj-art-f504bd43f00e4e94b4b2011cd1860dc1 |
| institution | Kabale University |
| issn | 1095-953X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj-art-f504bd43f00e4e94b4b2011cd1860dc12025-02-07T04:46:53ZengElsevierNeurobiology of Disease1095-953X2025-03-01206106828Positron emission tomography molecular imaging for pathological visualization in multiple system atrophyLa Dong0Rui Zhou1Jinyun Zhou2Ke Liu3Chentao Jin4Jing Wang5Chenxi Xue6Mei Tian7Hong Zhang8Yan Zhong9Department of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 31009, China; Institute of Nuclear Medicine and Molecular Imaging of Zhejiang University, Hangzhou, Zhejiang 31009, China; Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, Zhejiang 31009, ChinaDepartment of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 31009, China; Institute of Nuclear Medicine and Molecular Imaging of Zhejiang University, Hangzhou, Zhejiang 31009, China; Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, Zhejiang 31009, ChinaDepartment of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 31009, China; Institute of Nuclear Medicine and Molecular Imaging of Zhejiang University, Hangzhou, Zhejiang 31009, China; Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, Zhejiang 31009, ChinaDepartment of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 31009, China; Institute of Nuclear Medicine and Molecular Imaging of Zhejiang University, Hangzhou, Zhejiang 31009, China; Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, Zhejiang 31009, ChinaDepartment of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 31009, China; Institute of Nuclear Medicine and Molecular Imaging of Zhejiang University, Hangzhou, Zhejiang 31009, China; Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, Zhejiang 31009, ChinaDepartment of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 31009, China; Institute of Nuclear Medicine and Molecular Imaging of Zhejiang University, Hangzhou, Zhejiang 31009, China; Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, Zhejiang 31009, ChinaDepartment of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 31009, China; Institute of Nuclear Medicine and Molecular Imaging of Zhejiang University, Hangzhou, Zhejiang 31009, China; Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, Zhejiang 31009, China; Human Phenome Institute, Fudan University, Shanghai 200040, ChinaDepartment of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 31009, China; Institute of Nuclear Medicine and Molecular Imaging of Zhejiang University, Hangzhou, Zhejiang 31009, China; Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, Zhejiang 31009, China; Human Phenome Institute, Fudan University, Shanghai 200040, China; Corresponding authors at: Department of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 31009, China.Department of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 31009, China; Institute of Nuclear Medicine and Molecular Imaging of Zhejiang University, Hangzhou, Zhejiang 31009, China; Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, Zhejiang 31009, China; College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, Zhejiang 310014, China; Key Laboratory for Biomedical Engineering of Ministry of Education, Zhejiang University, Hangzhou, Zhejiang 310014, China; Corresponding authors at: Department of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 31009, China.Department of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 31009, China; Institute of Nuclear Medicine and Molecular Imaging of Zhejiang University, Hangzhou, Zhejiang 31009, China; Key Laboratory of Medical Molecular Imaging of Zhejiang Province, Hangzhou, Zhejiang 31009, China; Key Laboratory for Biomedical Engineering of Ministry of Education, Zhejiang University, Hangzhou, Zhejiang 310014, China; Corresponding authors at: Department of Nuclear Medicine and PET Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 31009, China.Multiple system atrophy (MSA) is a complex, heterogeneous neurodegenerative disorder characterized by a multifaceted pathogenesis. Its key pathological hallmark is the abnormal aggregation of α-synuclein, which triggers neuroinflammation, disrupts both dopaminergic and non-dopaminergic systems, and results in metabolic abnormalities in the brain. Positron emission tomography (PET) is a non-invasive technique that enables the visualization, characterization, and quantification of these pathological processes from diverse perspectives using radiolabeled agents. PET imaging of molecular events provides valuable insights into the underlying pathomechanisms of MSA and holds significant promise for the development of imaging biomarkers, which could greatly improve disease assessment and management. In this review, we focused on the pathological mechanisms of MSA, summarized relevant targets and radiopharmaceuticals, and discussed the clinical applications and future perspectives of PET molecular imaging in MSA.http://www.sciencedirect.com/science/article/pii/S0969996125000440Multiple system atrophyPositron emission tomographyα-SynucleinInflammationDopaminergic and non-dopaminergic systemBrain metabolism |
| spellingShingle | La Dong Rui Zhou Jinyun Zhou Ke Liu Chentao Jin Jing Wang Chenxi Xue Mei Tian Hong Zhang Yan Zhong Positron emission tomography molecular imaging for pathological visualization in multiple system atrophy Neurobiology of Disease Multiple system atrophy Positron emission tomography α-Synuclein Inflammation Dopaminergic and non-dopaminergic system Brain metabolism |
| title | Positron emission tomography molecular imaging for pathological visualization in multiple system atrophy |
| title_full | Positron emission tomography molecular imaging for pathological visualization in multiple system atrophy |
| title_fullStr | Positron emission tomography molecular imaging for pathological visualization in multiple system atrophy |
| title_full_unstemmed | Positron emission tomography molecular imaging for pathological visualization in multiple system atrophy |
| title_short | Positron emission tomography molecular imaging for pathological visualization in multiple system atrophy |
| title_sort | positron emission tomography molecular imaging for pathological visualization in multiple system atrophy |
| topic | Multiple system atrophy Positron emission tomography α-Synuclein Inflammation Dopaminergic and non-dopaminergic system Brain metabolism |
| url | http://www.sciencedirect.com/science/article/pii/S0969996125000440 |
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