Placental Maspin Gene Expression Pattern May Be Used to Distinguish Between Preeclampsia and Intrauterine Growth Restriction
Objective: Maspin is one of the members of serin protease inhibitor superfamily, and acts as a tumor suppressor protein. Here we report maspin expression in placental tissues of preeclampsia or intrauterine growth retardation pregnancies. Study Design: Maspin expression level was analyzed by semi-...
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| Format: | Article |
| Language: | English |
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Medical Network
2021-08-01
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| Series: | Gynecology Obstetrics & Reproductive Medicine |
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| Online Access: | https://gorm.com.tr/index.php/GORM/article/view/969 |
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| author | Gogsen Onalan Yunus Kasim Terzi Yusuf Aytac Tohma Erkan Yurtcu Esra Kuscu Feride Iffet Sahin Hulusi Bulent Zeyneloglu |
| author_facet | Gogsen Onalan Yunus Kasim Terzi Yusuf Aytac Tohma Erkan Yurtcu Esra Kuscu Feride Iffet Sahin Hulusi Bulent Zeyneloglu |
| author_sort | Gogsen Onalan |
| collection | DOAJ |
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Objective: Maspin is one of the members of serin protease inhibitor superfamily, and acts as a tumor suppressor protein. Here we report maspin expression in placental tissues of preeclampsia or intrauterine growth retardation pregnancies.
Study Design: Maspin expression level was analyzed by semi-quantitative RT-PCR method. For this purpose, placental tissue samples were obtained from pregnancies 13 with intrauterine growth retardation, and 6 with preeclampsia, and also 12 tissues from women without preeclampsia or intrauterine growth retardation history were included as controls.
Results: Maspin expression was found to be 11-fold higher in placentas from preeclampsia patients than placentas from intrauterine growth retardation patients (p=0.036). However, there was no difference between preeclampsia and control groups (p=0.76), and intrauterine growth retardation and control groups (p=0.849).
Conclusion: As far as we know this is the first study reporting expression level of maspin in placental tissues of pregnancies with intrauterine growth retardation. These findings support that molecular pathology between preeclampsia and IUGR might be different at the molecular level and maspin levels in the placenta may be used to differentiate preeclampsia from IUGR.
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| format | Article |
| id | doaj-art-f55c022b13ee45dba2386ded7f374b89 |
| institution | Kabale University |
| issn | 1300-4751 2602-4918 |
| language | English |
| publishDate | 2021-08-01 |
| publisher | Medical Network |
| record_format | Article |
| series | Gynecology Obstetrics & Reproductive Medicine |
| spelling | doaj-art-f55c022b13ee45dba2386ded7f374b892025-02-11T21:12:59ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512602-49182021-08-0127210.21613/GORM.2019.969Placental Maspin Gene Expression Pattern May Be Used to Distinguish Between Preeclampsia and Intrauterine Growth RestrictionGogsen Onalan0Yunus Kasim Terzi1Yusuf Aytac Tohma2Erkan Yurtcu3Esra Kuscu4Feride Iffet Sahin5Hulusi Bulent Zeyneloglu6Baskent UniversityBaskent UniversityBaskent University Medical SchoolBaskent UniversityBaskent UniversityBaskent UniversityBaskent University Objective: Maspin is one of the members of serin protease inhibitor superfamily, and acts as a tumor suppressor protein. Here we report maspin expression in placental tissues of preeclampsia or intrauterine growth retardation pregnancies. Study Design: Maspin expression level was analyzed by semi-quantitative RT-PCR method. For this purpose, placental tissue samples were obtained from pregnancies 13 with intrauterine growth retardation, and 6 with preeclampsia, and also 12 tissues from women without preeclampsia or intrauterine growth retardation history were included as controls. Results: Maspin expression was found to be 11-fold higher in placentas from preeclampsia patients than placentas from intrauterine growth retardation patients (p=0.036). However, there was no difference between preeclampsia and control groups (p=0.76), and intrauterine growth retardation and control groups (p=0.849). Conclusion: As far as we know this is the first study reporting expression level of maspin in placental tissues of pregnancies with intrauterine growth retardation. These findings support that molecular pathology between preeclampsia and IUGR might be different at the molecular level and maspin levels in the placenta may be used to differentiate preeclampsia from IUGR. https://gorm.com.tr/index.php/GORM/article/view/969Intrauterine growth restrictionMaspinPreeclampsiaPregnancy |
| spellingShingle | Gogsen Onalan Yunus Kasim Terzi Yusuf Aytac Tohma Erkan Yurtcu Esra Kuscu Feride Iffet Sahin Hulusi Bulent Zeyneloglu Placental Maspin Gene Expression Pattern May Be Used to Distinguish Between Preeclampsia and Intrauterine Growth Restriction Gynecology Obstetrics & Reproductive Medicine Intrauterine growth restriction Maspin Preeclampsia Pregnancy |
| title | Placental Maspin Gene Expression Pattern May Be Used to Distinguish Between Preeclampsia and Intrauterine Growth Restriction |
| title_full | Placental Maspin Gene Expression Pattern May Be Used to Distinguish Between Preeclampsia and Intrauterine Growth Restriction |
| title_fullStr | Placental Maspin Gene Expression Pattern May Be Used to Distinguish Between Preeclampsia and Intrauterine Growth Restriction |
| title_full_unstemmed | Placental Maspin Gene Expression Pattern May Be Used to Distinguish Between Preeclampsia and Intrauterine Growth Restriction |
| title_short | Placental Maspin Gene Expression Pattern May Be Used to Distinguish Between Preeclampsia and Intrauterine Growth Restriction |
| title_sort | placental maspin gene expression pattern may be used to distinguish between preeclampsia and intrauterine growth restriction |
| topic | Intrauterine growth restriction Maspin Preeclampsia Pregnancy |
| url | https://gorm.com.tr/index.php/GORM/article/view/969 |
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