HINT1 suppression protects against age-related cardiac dysfunction by enhancing mitochondrial biogenesis

HINT1 suppression protects against age-related cardiac dysfunction by enhancing mitochondrial biogenesis

Objective: Cardiac function declines with age, impairing exercise tolerance and negatively impacting healthy aging. However, mechanisms driving age-related declines in cardiac function are not fully understood. Methods: We examined mechanisms underlying age-related cardiac dysfunction using 3- and 2...

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Main Authors: Michio Sato, Tsuyoshi Kadomatsu, Jun Morinaga, Yuya Kinoshita, Daisuke Torigoe, Haruki Horiguchi, Sumio Ohtsuki, Shuji Yamamura, Ryoko Kusaba, Takanori Yamaguchi, Goro Yoshioka, Kimi Araki, Tomohiko Wakayama, Keishi Miyata, Koichi Node, Yuichi Oike
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Molecular Metabolism
Subjects:
Cardiac aging
Heart failure
Mitochondrial biogenesis
Calorie restriction
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877825000146
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