Apical periodontitis in inflammatory bowel disease: a meta-analysis at patient and tooth level
Apical periodontitis (AP) is the local inflammation of periapical tissues originating from the dental pulp disease. Cumulative evidence suggests a link between oral and gastro-intestinal systems in both health and disease. In this context, the relationship between AP and inflammatory bowel diseases...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Dental Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fdmed.2025.1553914/full |
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| author | Giusy Rita Maria La Rosa Alejandro Ismael Lorenzo-Pouso Vito Carlo Alberto Caponio Mariangela Valentina Puci Mariangela Valentina Puci |
| author_facet | Giusy Rita Maria La Rosa Alejandro Ismael Lorenzo-Pouso Vito Carlo Alberto Caponio Mariangela Valentina Puci Mariangela Valentina Puci |
| author_sort | Giusy Rita Maria La Rosa |
| collection | DOAJ |
| description | Apical periodontitis (AP) is the local inflammation of periapical tissues originating from the dental pulp disease. Cumulative evidence suggests a link between oral and gastro-intestinal systems in both health and disease. In this context, the relationship between AP and inflammatory bowel diseases (IBDs) has not yet been elucidated. The aims of this systematic review and meta-analysis were to describe the prevalence of AP in patients with IBDs and evaluate the potential association between AP and IBDs. Electronic (Embase, PubMed, Scopus, Web of Science) and manual literature searches were conducted from inception to 31 October, 2023 (updated in August, 2024). Strict inclusion criteria were applied to identify observational and experimental clinical studies on AP in IBDs patients. The bias risk was assessed using the Joanna Briggs Institute critical appraisal tools and a biases' report selected from the Oxford Centre for Evidence Based Medicine Catalogue of Bias. A meta-analysis was performed to determine the pooled prevalence and risk of AP at individual and tooth level and the quality of evidence was assessed by the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach. The search strategy identified 82 articles with 5 studies included (657 subjects, 7,142 teeth). The overall proportion of AP was 58% at patient level (95% CI = 37%–78%, I2 = 95.3%) and 7% at tooth level (95% CI = 2%–15%; I2 = 99.2%). AP was prevalent in IBDs subjects than in healthy controls, both at patient and tooth level. The pooled OR was 1.57 (95% CI = 1.04–2.35; P = 0.038; I2 = 20%) at patient level, and 1.91 (95% CI = 1.16–3.15; P = 0.011; I2 = 82%) at tooth level. A potential association between AP and IBDs is plausible, although the quality evidence was low to very low. Longitudinal and experimental studies should be conducted to better understand the relationship between these two conditions and explore any potential causative factors.
Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=411038, PROSPERO (CRD42023411038). |
| format | Article |
| id | doaj-art-f5cbcfa3a0054f3ebdefc9864839ff27 |
| institution | Kabale University |
| issn | 2673-4915 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Dental Medicine |
| spelling | doaj-art-f5cbcfa3a0054f3ebdefc9864839ff272025-02-10T06:49:07ZengFrontiers Media S.A.Frontiers in Dental Medicine2673-49152025-02-01610.3389/fdmed.2025.15539141553914Apical periodontitis in inflammatory bowel disease: a meta-analysis at patient and tooth levelGiusy Rita Maria La Rosa0Alejandro Ismael Lorenzo-Pouso1Vito Carlo Alberto Caponio2Mariangela Valentina Puci3Mariangela Valentina Puci4Department of General Surgery and Medical-Surgical Specialties, University of Catania, Catania, ItalyOral Medicine, Oral Surgery and Implantology Unit (MedOralRes Group), Faculty of Medicine and Dentistry, University of Santiago de Compostela, A Coruña, SpainDepartment of Clinical and Experimental Medicine, University of Foggia, Foggia, ItalyBiostatistics and Clinical Epidemiology Unit, Department of Public Health, Experimental Medicine and Forensic Science, University of Pavia, Pavia, ItalyClinical Epidemiology and Medical Statistics Unit, Department of Medicine, Surgery and Pharmacy, University of Sassari, Sassari, ItalyApical periodontitis (AP) is the local inflammation of periapical tissues originating from the dental pulp disease. Cumulative evidence suggests a link between oral and gastro-intestinal systems in both health and disease. In this context, the relationship between AP and inflammatory bowel diseases (IBDs) has not yet been elucidated. The aims of this systematic review and meta-analysis were to describe the prevalence of AP in patients with IBDs and evaluate the potential association between AP and IBDs. Electronic (Embase, PubMed, Scopus, Web of Science) and manual literature searches were conducted from inception to 31 October, 2023 (updated in August, 2024). Strict inclusion criteria were applied to identify observational and experimental clinical studies on AP in IBDs patients. The bias risk was assessed using the Joanna Briggs Institute critical appraisal tools and a biases' report selected from the Oxford Centre for Evidence Based Medicine Catalogue of Bias. A meta-analysis was performed to determine the pooled prevalence and risk of AP at individual and tooth level and the quality of evidence was assessed by the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach. The search strategy identified 82 articles with 5 studies included (657 subjects, 7,142 teeth). The overall proportion of AP was 58% at patient level (95% CI = 37%–78%, I2 = 95.3%) and 7% at tooth level (95% CI = 2%–15%; I2 = 99.2%). AP was prevalent in IBDs subjects than in healthy controls, both at patient and tooth level. The pooled OR was 1.57 (95% CI = 1.04–2.35; P = 0.038; I2 = 20%) at patient level, and 1.91 (95% CI = 1.16–3.15; P = 0.011; I2 = 82%) at tooth level. A potential association between AP and IBDs is plausible, although the quality evidence was low to very low. Longitudinal and experimental studies should be conducted to better understand the relationship between these two conditions and explore any potential causative factors. Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=411038, PROSPERO (CRD42023411038).https://www.frontiersin.org/articles/10.3389/fdmed.2025.1553914/fullapical periodontitisinflammatory bowel diseaseCrohn's diseasesystematic reviewmeta-analysis |
| spellingShingle | Giusy Rita Maria La Rosa Alejandro Ismael Lorenzo-Pouso Vito Carlo Alberto Caponio Mariangela Valentina Puci Mariangela Valentina Puci Apical periodontitis in inflammatory bowel disease: a meta-analysis at patient and tooth level Frontiers in Dental Medicine apical periodontitis inflammatory bowel disease Crohn's disease systematic review meta-analysis |
| title | Apical periodontitis in inflammatory bowel disease: a meta-analysis at patient and tooth level |
| title_full | Apical periodontitis in inflammatory bowel disease: a meta-analysis at patient and tooth level |
| title_fullStr | Apical periodontitis in inflammatory bowel disease: a meta-analysis at patient and tooth level |
| title_full_unstemmed | Apical periodontitis in inflammatory bowel disease: a meta-analysis at patient and tooth level |
| title_short | Apical periodontitis in inflammatory bowel disease: a meta-analysis at patient and tooth level |
| title_sort | apical periodontitis in inflammatory bowel disease a meta analysis at patient and tooth level |
| topic | apical periodontitis inflammatory bowel disease Crohn's disease systematic review meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fdmed.2025.1553914/full |
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