Multi-INTACT: integrative analysis of the genome, transcriptome, and proteome identifies causal mechanisms of complex traits

Multi-INTACT: integrative analysis of the genome, transcriptome, and proteome identifies causal mechanisms of complex traits

Abstract We present multi-integration of transcriptome-wide association studies and colocalization (Multi-INTACT), an algorithm that models multiple “gene products” (e.g., encoded RNA transcript and protein levels) to implicate causal genes and relevant gene products. In simulations, Multi-INTACT ac...

Full description

Saved in:
Bibliographic Details
Main Authors: Jeffrey Okamoto, Xianyong Yin, Brady Ryan, Joshua Chiou, Francesca Luca, Roger Pique-Regi, Hae Kyung Im, Jean Morrison, Charles Burant, Eric B. Fauman, Markku Laakso, Michael Boehnke, Xiaoquan Wen
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Genome Biology
Online Access:https://doi.org/10.1186/s13059-025-03480-2
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items