The impact of PD-L1 expression status on the prognosis of ALK-positive lung cancer patients
Objective: This study analyzes the clinical characteristics of ALK-positive lung cancer patients and the impact of PD-L1 expression on their prognosis, providing insights for diagnosis and treatment. Materials and methods: A total of 291 ALK-positive lung cancer patients, tested for PD-L1 expression...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Cancer Treatment and Research Communications |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468294225000061 |
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| _version_ | 1823864290857189376 |
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| author | Li Wang Yingjun Kong Yao Zhang Chuanyong Mu |
| author_facet | Li Wang Yingjun Kong Yao Zhang Chuanyong Mu |
| author_sort | Li Wang |
| collection | DOAJ |
| description | Objective: This study analyzes the clinical characteristics of ALK-positive lung cancer patients and the impact of PD-L1 expression on their prognosis, providing insights for diagnosis and treatment. Materials and methods: A total of 291 ALK-positive lung cancer patients, tested for PD-L1 expression at the First Affiliated Hospital of Soochow University between January 2019 and November 2021, were included. Clinical data and prognostic information were collected. Statistical analysis was conducted using SPSS 26.0 to explore the relationship between clinical features and prognosis. Results: In ALK positive patients, the PD-L1 positivity rate was 59.8 %, with 19.2 % showing strong positivity. PD-L1 positive patients were predominantly male, over 55 years old, and presented more clinical symptoms, higher Ki-67 expression, larger tumor sizes, and more advanced disease stages. The progression-free survival (PFS) and overall survival (OS) were significantly lower in the ALK+PD-L1+ group compared to the ALK+PD-L1- group. Those receiving targeted therapy in stage IIIB-IVB non-squamous non-small cell lung cancer had significantly higher PFS and OS. Conclusion: PD-L1 positivity is common in ALK-positive lung cancer patients and correlates with poorer prognosis. PD-L1 serves as an independent predictor of adverse outcomes, indicating its potential as a biomarker for assessing lung cancer severity and prognosis. |
| format | Article |
| id | doaj-art-f72eb4730c374abc8be9204475cebf16 |
| institution | Kabale University |
| issn | 2468-2942 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cancer Treatment and Research Communications |
| spelling | doaj-art-f72eb4730c374abc8be9204475cebf162025-02-09T05:00:47ZengElsevierCancer Treatment and Research Communications2468-29422024-01-0142100868The impact of PD-L1 expression status on the prognosis of ALK-positive lung cancer patientsLi Wang0Yingjun Kong1Yao Zhang2Chuanyong Mu3Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, ChinaDepartment of Respiratory Medicine, Pingshan District Central Hospital of Shenzhen, Guangdong, 518122, ChinaDepartment of Respiratory Medicine, Pingshan District Central Hospital of Shenzhen, Guangdong, 518122, ChinaDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China; Corresponding author at: Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.Objective: This study analyzes the clinical characteristics of ALK-positive lung cancer patients and the impact of PD-L1 expression on their prognosis, providing insights for diagnosis and treatment. Materials and methods: A total of 291 ALK-positive lung cancer patients, tested for PD-L1 expression at the First Affiliated Hospital of Soochow University between January 2019 and November 2021, were included. Clinical data and prognostic information were collected. Statistical analysis was conducted using SPSS 26.0 to explore the relationship between clinical features and prognosis. Results: In ALK positive patients, the PD-L1 positivity rate was 59.8 %, with 19.2 % showing strong positivity. PD-L1 positive patients were predominantly male, over 55 years old, and presented more clinical symptoms, higher Ki-67 expression, larger tumor sizes, and more advanced disease stages. The progression-free survival (PFS) and overall survival (OS) were significantly lower in the ALK+PD-L1+ group compared to the ALK+PD-L1- group. Those receiving targeted therapy in stage IIIB-IVB non-squamous non-small cell lung cancer had significantly higher PFS and OS. Conclusion: PD-L1 positivity is common in ALK-positive lung cancer patients and correlates with poorer prognosis. PD-L1 serves as an independent predictor of adverse outcomes, indicating its potential as a biomarker for assessing lung cancer severity and prognosis.http://www.sciencedirect.com/science/article/pii/S2468294225000061ALK gene mutationPD-L1Non-squamous non-small cell lung cancerClinical characteristicsPrognosis |
| spellingShingle | Li Wang Yingjun Kong Yao Zhang Chuanyong Mu The impact of PD-L1 expression status on the prognosis of ALK-positive lung cancer patients Cancer Treatment and Research Communications ALK gene mutation PD-L1 Non-squamous non-small cell lung cancer Clinical characteristics Prognosis |
| title | The impact of PD-L1 expression status on the prognosis of ALK-positive lung cancer patients |
| title_full | The impact of PD-L1 expression status on the prognosis of ALK-positive lung cancer patients |
| title_fullStr | The impact of PD-L1 expression status on the prognosis of ALK-positive lung cancer patients |
| title_full_unstemmed | The impact of PD-L1 expression status on the prognosis of ALK-positive lung cancer patients |
| title_short | The impact of PD-L1 expression status on the prognosis of ALK-positive lung cancer patients |
| title_sort | impact of pd l1 expression status on the prognosis of alk positive lung cancer patients |
| topic | ALK gene mutation PD-L1 Non-squamous non-small cell lung cancer Clinical characteristics Prognosis |
| url | http://www.sciencedirect.com/science/article/pii/S2468294225000061 |
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