Germ granule-mediated mRNA storage and translational control
Germ cells depend on specialized post-transcriptional regulation for proper development and function, much of which is mediated by dynamic RNA granules. These membrane-less organelles form through the condensation of RNA and proteins, governed by multivalent biomolecular interactions. RNA granules c...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | RNA Biology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/15476286.2025.2462276 |
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| _version_ | 1825206992633856000 |
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| author | Hoang-Anh Pham-Bui Mihye Lee |
| author_facet | Hoang-Anh Pham-Bui Mihye Lee |
| author_sort | Hoang-Anh Pham-Bui |
| collection | DOAJ |
| description | Germ cells depend on specialized post-transcriptional regulation for proper development and function, much of which is mediated by dynamic RNA granules. These membrane-less organelles form through the condensation of RNA and proteins, governed by multivalent biomolecular interactions. RNA granules compartmentalize cellular components, selectively enriching specific factors and modulating biochemical reactions. Over recent decades, various types of RNA granules have been identified in germ cells across species, with extensive studies uncovering their molecular roles and developmental significance. This review explores the mRNA regulatory mechanisms mediated by RNA granules in germ cells. We discuss the distinct spatial organization of specific granule components and the variations in material states of germ granules, which contribute to the regulation of mRNA storage and translation. Additionally, we highlight emerging research on how changes in these material states, during developmental stages, reflect the dynamic nature of germ granules and their critical role in development. |
| format | Article |
| id | doaj-art-f811224ba42c4308af038611a8547042 |
| institution | Kabale University |
| issn | 1547-6286 1555-8584 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | RNA Biology |
| spelling | doaj-art-f811224ba42c4308af038611a85470422025-02-07T03:56:13ZengTaylor & Francis GroupRNA Biology1547-62861555-85842025-12-0122111110.1080/15476286.2025.2462276Germ granule-mediated mRNA storage and translational controlHoang-Anh Pham-Bui0Mihye Lee1Soonchunhyang Institute of Medi-Bio Science, Soonchunhyang University, Cheonan-si, KoreaSoonchunhyang Institute of Medi-Bio Science, Soonchunhyang University, Cheonan-si, KoreaGerm cells depend on specialized post-transcriptional regulation for proper development and function, much of which is mediated by dynamic RNA granules. These membrane-less organelles form through the condensation of RNA and proteins, governed by multivalent biomolecular interactions. RNA granules compartmentalize cellular components, selectively enriching specific factors and modulating biochemical reactions. Over recent decades, various types of RNA granules have been identified in germ cells across species, with extensive studies uncovering their molecular roles and developmental significance. This review explores the mRNA regulatory mechanisms mediated by RNA granules in germ cells. We discuss the distinct spatial organization of specific granule components and the variations in material states of germ granules, which contribute to the regulation of mRNA storage and translation. Additionally, we highlight emerging research on how changes in these material states, during developmental stages, reflect the dynamic nature of germ granules and their critical role in development.https://www.tandfonline.com/doi/10.1080/15476286.2025.2462276RNA granulegerm cellspost-transcriptional regulationmRNA storagetranslational controlphase separation |
| spellingShingle | Hoang-Anh Pham-Bui Mihye Lee Germ granule-mediated mRNA storage and translational control RNA Biology RNA granule germ cells post-transcriptional regulation mRNA storage translational control phase separation |
| title | Germ granule-mediated mRNA storage and translational control |
| title_full | Germ granule-mediated mRNA storage and translational control |
| title_fullStr | Germ granule-mediated mRNA storage and translational control |
| title_full_unstemmed | Germ granule-mediated mRNA storage and translational control |
| title_short | Germ granule-mediated mRNA storage and translational control |
| title_sort | germ granule mediated mrna storage and translational control |
| topic | RNA granule germ cells post-transcriptional regulation mRNA storage translational control phase separation |
| url | https://www.tandfonline.com/doi/10.1080/15476286.2025.2462276 |
| work_keys_str_mv | AT hoanganhphambui germgranulemediatedmrnastorageandtranslationalcontrol AT mihyelee germgranulemediatedmrnastorageandtranslationalcontrol |