Chronic exposure to diesel engine exhaust and alteration of the airway bacteriome
The detrimental effects of diesel engine exhaust (DEE) on public health are receiving increasing attention, particularly concerning respiratory health. Our understanding of the associations of the airway bacterial ecosystem with exposure to DEE and respiratory health remains limited. Our study aimed...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-02-01
|
| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325001939 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823856951016030208 |
|---|---|
| author | Menghui Jiang Yongwei Yan Tao Wang Bojia Wang Yanting Li Jinglong Tang Yuxin Zheng |
| author_facet | Menghui Jiang Yongwei Yan Tao Wang Bojia Wang Yanting Li Jinglong Tang Yuxin Zheng |
| author_sort | Menghui Jiang |
| collection | DOAJ |
| description | The detrimental effects of diesel engine exhaust (DEE) on public health are receiving increasing attention, particularly concerning respiratory health. Our understanding of the associations of the airway bacterial ecosystem with exposure to DEE and respiratory health remains limited. Our study aimed to identify the airway bacterial signature and assess its correlation with respiratory health in occupational populations. In this study, we collected induced sputum from 54 diesel-exposed workers and 52 unexposed controls. The exposed participants experienced lower forced vital capacity (FVC) and forced expiratory volume in one second (FEV1) than controls. Importantly, the overall airway bacterial signature and assemblage in exposed individuals differed significantly from controls. The relative abundance of Prevotella nanceiensis, Prevotella shahii, Aggregatibacter segnis, and Lachnoanaerobaculum umeaense displayed remarkable differences between the two groups. Furthermore, exposed individuals showed a less robust correlation network and fewer keystone species in their airway bacteriome than controls. Furthermore, the Spearman analysis indicated notable correlations of specific species with carbon content in airway macrophages (CCAM), club cell protein (CC16), FVC and FEV1. Taken together, our study provided new information on the difference in the airway bacterial signature under exposure to DEE and supported a potential new link between specific species and lung function in occupational populations. |
| format | Article |
| id | doaj-art-f86ebfd1d9ae489f93971d73e3e45d18 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-f86ebfd1d9ae489f93971d73e3e45d182025-02-12T05:30:22ZengElsevierEcotoxicology and Environmental Safety0147-65132025-02-01291117857Chronic exposure to diesel engine exhaust and alteration of the airway bacteriomeMenghui Jiang0Yongwei Yan1Tao Wang2Bojia Wang3Yanting Li4Jinglong Tang5Yuxin Zheng6School of Public Health, Qingdao University, Qingdao, Shandong, China; Corresponding authors.State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, Shandong, ChinaUniversity of Health and Rehabilitation Sciences, Qingdao, Shandong, ChinaSchool of Public Health, Qingdao University, Qingdao, Shandong, ChinaSchool of Public Health, Qingdao University, Qingdao, Shandong, ChinaSchool of Public Health, Qingdao University, Qingdao, Shandong, ChinaSchool of Public Health, Qingdao University, Qingdao, Shandong, China; Corresponding authors.The detrimental effects of diesel engine exhaust (DEE) on public health are receiving increasing attention, particularly concerning respiratory health. Our understanding of the associations of the airway bacterial ecosystem with exposure to DEE and respiratory health remains limited. Our study aimed to identify the airway bacterial signature and assess its correlation with respiratory health in occupational populations. In this study, we collected induced sputum from 54 diesel-exposed workers and 52 unexposed controls. The exposed participants experienced lower forced vital capacity (FVC) and forced expiratory volume in one second (FEV1) than controls. Importantly, the overall airway bacterial signature and assemblage in exposed individuals differed significantly from controls. The relative abundance of Prevotella nanceiensis, Prevotella shahii, Aggregatibacter segnis, and Lachnoanaerobaculum umeaense displayed remarkable differences between the two groups. Furthermore, exposed individuals showed a less robust correlation network and fewer keystone species in their airway bacteriome than controls. Furthermore, the Spearman analysis indicated notable correlations of specific species with carbon content in airway macrophages (CCAM), club cell protein (CC16), FVC and FEV1. Taken together, our study provided new information on the difference in the airway bacterial signature under exposure to DEE and supported a potential new link between specific species and lung function in occupational populations.http://www.sciencedirect.com/science/article/pii/S0147651325001939Diesel engine exhaustAirway bacteriomeRespiratory health |
| spellingShingle | Menghui Jiang Yongwei Yan Tao Wang Bojia Wang Yanting Li Jinglong Tang Yuxin Zheng Chronic exposure to diesel engine exhaust and alteration of the airway bacteriome Ecotoxicology and Environmental Safety Diesel engine exhaust Airway bacteriome Respiratory health |
| title | Chronic exposure to diesel engine exhaust and alteration of the airway bacteriome |
| title_full | Chronic exposure to diesel engine exhaust and alteration of the airway bacteriome |
| title_fullStr | Chronic exposure to diesel engine exhaust and alteration of the airway bacteriome |
| title_full_unstemmed | Chronic exposure to diesel engine exhaust and alteration of the airway bacteriome |
| title_short | Chronic exposure to diesel engine exhaust and alteration of the airway bacteriome |
| title_sort | chronic exposure to diesel engine exhaust and alteration of the airway bacteriome |
| topic | Diesel engine exhaust Airway bacteriome Respiratory health |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325001939 |
| work_keys_str_mv | AT menghuijiang chronicexposuretodieselengineexhaustandalterationoftheairwaybacteriome AT yongweiyan chronicexposuretodieselengineexhaustandalterationoftheairwaybacteriome AT taowang chronicexposuretodieselengineexhaustandalterationoftheairwaybacteriome AT bojiawang chronicexposuretodieselengineexhaustandalterationoftheairwaybacteriome AT yantingli chronicexposuretodieselengineexhaustandalterationoftheairwaybacteriome AT jinglongtang chronicexposuretodieselengineexhaustandalterationoftheairwaybacteriome AT yuxinzheng chronicexposuretodieselengineexhaustandalterationoftheairwaybacteriome |