Follistatin like-1 aggravates silica-induced mouse lung injury
Abstract Occupational inhalation of dust, such as crystalline silica, for prolonged periods in the workplace leads to fibrotic lung diseases worldwide. The mechanisms underlying the diseases are unknown, so that no effective treatment exists for these conditions. We found elevated levels of follista...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-017-00478-0 |
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| _version_ | 1823862268516892672 |
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| author | Yinshan Fang Si Zhang Xiaohe Li Fangxin Jiang Qiao Ye Wen Ning |
| author_facet | Yinshan Fang Si Zhang Xiaohe Li Fangxin Jiang Qiao Ye Wen Ning |
| author_sort | Yinshan Fang |
| collection | DOAJ |
| description | Abstract Occupational inhalation of dust, such as crystalline silica, for prolonged periods in the workplace leads to fibrotic lung diseases worldwide. The mechanisms underlying the diseases are unknown, so that no effective treatment exists for these conditions. We found elevated levels of follistatin like 1 (FSTL1) in serum from patients with silicosis and in lungs from silica-induced mouse model. The induced Fstl1 regulated inflammation response via activation of nod-like receptor family, pyrin domain containing 3v (NLRP3) inflammasome-mediated IL-1β production from macrophages. Meanwhile, Fstl1 promoted fibrosis via positive regulation of TGF-β1 signaling. Haploinsufficiency of Fstl1 or blockage of FSTL1 with a neutralizing antibody was protective from silica-induced lung injury in mice in vivo. Our data suggest that Fstl1 plays an important role in lung fibrosis, and may serve as a novel therapeutic target for treatment of silicosis. |
| format | Article |
| id | doaj-art-f87cb8a5f8e14970a88b7d22e5ecf7c9 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2017-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-f87cb8a5f8e14970a88b7d22e5ecf7c92025-02-09T12:38:29ZengNature PortfolioScientific Reports2045-23222017-03-017111210.1038/s41598-017-00478-0Follistatin like-1 aggravates silica-induced mouse lung injuryYinshan Fang0Si Zhang1Xiaohe Li2Fangxin Jiang3Qiao Ye4Wen Ning5State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai UniversityState Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai UniversityState Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai UniversityState Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai UniversityDepartment of Occupational Diseases and Toxicology, Beijing Chao-Yang Hospital, Capital Medical UniversityState Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai UniversityAbstract Occupational inhalation of dust, such as crystalline silica, for prolonged periods in the workplace leads to fibrotic lung diseases worldwide. The mechanisms underlying the diseases are unknown, so that no effective treatment exists for these conditions. We found elevated levels of follistatin like 1 (FSTL1) in serum from patients with silicosis and in lungs from silica-induced mouse model. The induced Fstl1 regulated inflammation response via activation of nod-like receptor family, pyrin domain containing 3v (NLRP3) inflammasome-mediated IL-1β production from macrophages. Meanwhile, Fstl1 promoted fibrosis via positive regulation of TGF-β1 signaling. Haploinsufficiency of Fstl1 or blockage of FSTL1 with a neutralizing antibody was protective from silica-induced lung injury in mice in vivo. Our data suggest that Fstl1 plays an important role in lung fibrosis, and may serve as a novel therapeutic target for treatment of silicosis.https://doi.org/10.1038/s41598-017-00478-0 |
| spellingShingle | Yinshan Fang Si Zhang Xiaohe Li Fangxin Jiang Qiao Ye Wen Ning Follistatin like-1 aggravates silica-induced mouse lung injury Scientific Reports |
| title | Follistatin like-1 aggravates silica-induced mouse lung injury |
| title_full | Follistatin like-1 aggravates silica-induced mouse lung injury |
| title_fullStr | Follistatin like-1 aggravates silica-induced mouse lung injury |
| title_full_unstemmed | Follistatin like-1 aggravates silica-induced mouse lung injury |
| title_short | Follistatin like-1 aggravates silica-induced mouse lung injury |
| title_sort | follistatin like 1 aggravates silica induced mouse lung injury |
| url | https://doi.org/10.1038/s41598-017-00478-0 |
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