To Analyze the Effect of Platelet Count of Platelet-rich Plasma on Clinical Outcomes in Patients of Osteoarthritis of Knee
Purpose: The purpose of this study was to find the association between the platelet (PLT) count in PLT-rich plasma (PRP) injection and clinical response in knee osteoarthritis (KOA) patients. Materials and Methods: Fifty patients of Kellgren–Lawrence Grade 2 and 3 KOA were given single intra-articul...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-07-01
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| Series: | Journal of Orthopedics, Traumatology and Rehabilitation |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jotr.jotr_27_23 |
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| _version_ | 1823868533555068928 |
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| author | Amit Saraf Prakhar Agarwal Abhinav Kush |
| author_facet | Amit Saraf Prakhar Agarwal Abhinav Kush |
| author_sort | Amit Saraf |
| collection | DOAJ |
| description | Purpose:
The purpose of this study was to find the association between the platelet (PLT) count in PLT-rich plasma (PRP) injection and clinical response in knee osteoarthritis (KOA) patients.
Materials and Methods:
Fifty patients of Kellgren–Lawrence Grade 2 and 3 KOA were given single intra-articular PRP injection. Baseline PLT count was documented and PLT concentration of each PRP was documented and was classified as P1, P2, and P3 (as per PAW classification). This was compared to clinical results using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Visual Analog Scale (VAS) score at baseline, followed by 3, 6, and 9 months of follow-up.
Results:
There was a significant decrease in VAS score between the P1 and P2 and P1 and P3 groups at 9-month follow-up, with P = 0.028 (<0.05) and P = 0.01 (<0.05), respectively. Moreover, the WOMAC score significantly dropped among the P1 and P2 and P1 and P3 groups at 9-month follow-up, with P = 0.016 (<0.05) and P = 0.036 (<0.05), respectively.
Conclusion:
Both the VAS score and the WOMAC score have significantly decreased at 9-month follow-up period when the P1 group is compared to both P2 and P3 but not between P2 and P3, so it is concluded that for proper efficacy of PRP injection in OA knee Grades 2 and 3, concentration of platelets in prepared PRP should be more than baseline PLT concentration. |
| format | Article |
| id | doaj-art-f9fb8d6f4f564662bfdd7c7fe5d38053 |
| institution | Kabale University |
| issn | 0975-7341 2347-3746 |
| language | English |
| publishDate | 2023-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Orthopedics, Traumatology and Rehabilitation |
| spelling | doaj-art-f9fb8d6f4f564662bfdd7c7fe5d380532025-02-08T05:58:01ZengWolters Kluwer Medknow PublicationsJournal of Orthopedics, Traumatology and Rehabilitation0975-73412347-37462023-07-0115215515910.4103/jotr.jotr_27_23To Analyze the Effect of Platelet Count of Platelet-rich Plasma on Clinical Outcomes in Patients of Osteoarthritis of KneeAmit SarafPrakhar AgarwalAbhinav KushPurpose: The purpose of this study was to find the association between the platelet (PLT) count in PLT-rich plasma (PRP) injection and clinical response in knee osteoarthritis (KOA) patients. Materials and Methods: Fifty patients of Kellgren–Lawrence Grade 2 and 3 KOA were given single intra-articular PRP injection. Baseline PLT count was documented and PLT concentration of each PRP was documented and was classified as P1, P2, and P3 (as per PAW classification). This was compared to clinical results using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Visual Analog Scale (VAS) score at baseline, followed by 3, 6, and 9 months of follow-up. Results: There was a significant decrease in VAS score between the P1 and P2 and P1 and P3 groups at 9-month follow-up, with P = 0.028 (<0.05) and P = 0.01 (<0.05), respectively. Moreover, the WOMAC score significantly dropped among the P1 and P2 and P1 and P3 groups at 9-month follow-up, with P = 0.016 (<0.05) and P = 0.036 (<0.05), respectively. Conclusion: Both the VAS score and the WOMAC score have significantly decreased at 9-month follow-up period when the P1 group is compared to both P2 and P3 but not between P2 and P3, so it is concluded that for proper efficacy of PRP injection in OA knee Grades 2 and 3, concentration of platelets in prepared PRP should be more than baseline PLT concentration.https://journals.lww.com/10.4103/jotr.jotr_27_23intra-articularkellgren–lawrence gradingknee osteoarthritisplatelet-rich plasmavisual analog scalewestern ontario and mcmaster universities osteoarthritis index |
| spellingShingle | Amit Saraf Prakhar Agarwal Abhinav Kush To Analyze the Effect of Platelet Count of Platelet-rich Plasma on Clinical Outcomes in Patients of Osteoarthritis of Knee Journal of Orthopedics, Traumatology and Rehabilitation intra-articular kellgren–lawrence grading knee osteoarthritis platelet-rich plasma visual analog scale western ontario and mcmaster universities osteoarthritis index |
| title | To Analyze the Effect of Platelet Count of Platelet-rich Plasma on Clinical Outcomes in Patients of Osteoarthritis of Knee |
| title_full | To Analyze the Effect of Platelet Count of Platelet-rich Plasma on Clinical Outcomes in Patients of Osteoarthritis of Knee |
| title_fullStr | To Analyze the Effect of Platelet Count of Platelet-rich Plasma on Clinical Outcomes in Patients of Osteoarthritis of Knee |
| title_full_unstemmed | To Analyze the Effect of Platelet Count of Platelet-rich Plasma on Clinical Outcomes in Patients of Osteoarthritis of Knee |
| title_short | To Analyze the Effect of Platelet Count of Platelet-rich Plasma on Clinical Outcomes in Patients of Osteoarthritis of Knee |
| title_sort | to analyze the effect of platelet count of platelet rich plasma on clinical outcomes in patients of osteoarthritis of knee |
| topic | intra-articular kellgren–lawrence grading knee osteoarthritis platelet-rich plasma visual analog scale western ontario and mcmaster universities osteoarthritis index |
| url | https://journals.lww.com/10.4103/jotr.jotr_27_23 |
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