Exploring Novel Non-Operative Treatments for Osteoarthritis: An Examination of Innovative Therapies
Osteoarthritis (OA) is a prevalent degenerative joint disease that significantly impacts the quality of life of millions worldwide, particularly the elderly. While conventional non-surgical treatments, such as NSAIDs, intra-articular injections, and physical therapy, provide symptomatic relief, thei...
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| Format: | Article |
| Language: | English |
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Nicolaus Copernicus University in Toruń
2025-02-01
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| Series: | Quality in Sport |
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| Online Access: | https://apcz.umk.pl/QS/article/view/58169 |
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| author | Piotr Robert Bakuła Kamila Jałocha Joanna Zygadło |
| author_facet | Piotr Robert Bakuła Kamila Jałocha Joanna Zygadło |
| author_sort | Piotr Robert Bakuła |
| collection | DOAJ |
| description | Osteoarthritis (OA) is a prevalent degenerative joint disease that significantly impacts the quality of life of millions worldwide, particularly the elderly. While conventional non-surgical treatments, such as NSAIDs, intra-articular injections, and physical therapy, provide symptomatic relief, their long-term efficacy and safety remain limited. Recent advancements in understanding OA pathophysiology have spurred the development of innovative therapeutic strategies targeting disease progression. This review examines emerging pharmacological and regenerative approaches, including disease-modifying osteoarthritis drugs (DMOADs), biologics, and cell-based therapies. Cutting-edge technologies such as RNA interference, CRISPR/Cas9, and advanced regenerative medicine are also explored for their potential to revolutionize OA management. Additionally, the integration of novel therapies with traditional interventions is discussed, highlighting opportunities for a more personalized, multimodal approach to OA care. Despite significant progress, challenges such as translational hurdles, cost barriers, and long-term efficacy require further investigation. This review emphasizes the transformative potential of emerging therapies in addressing the unmet needs of OA patients and shaping future treatment paradigms.
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| format | Article |
| id | doaj-art-fa89c2494ce54264a04ae0c9fde6368b |
| institution | Kabale University |
| issn | 2450-3118 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nicolaus Copernicus University in Toruń |
| record_format | Article |
| series | Quality in Sport |
| spelling | doaj-art-fa89c2494ce54264a04ae0c9fde6368b2025-02-12T08:26:14ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182025-02-013810.12775/QS.2025.38.58169Exploring Novel Non-Operative Treatments for Osteoarthritis: An Examination of Innovative TherapiesPiotr Robert Bakuła0https://orcid.org/0009-0002-8066-5688Kamila Jałocha1https://orcid.org/0009-0003-5734-5261Joanna Zygadło2https://orcid.org/0000-0001-5377-5254Międzyleski Specialist Hospital in Warsaw, Bursztynowa 2, 04-749 Warsaw, PolandMedical University of Warsaw, Żwirki i Wigury 61, 02-091 Warsaw, Poland Medical University of Warsaw, Żwirki i Wigury 61, 02-091 Warsaw, Poland Osteoarthritis (OA) is a prevalent degenerative joint disease that significantly impacts the quality of life of millions worldwide, particularly the elderly. While conventional non-surgical treatments, such as NSAIDs, intra-articular injections, and physical therapy, provide symptomatic relief, their long-term efficacy and safety remain limited. Recent advancements in understanding OA pathophysiology have spurred the development of innovative therapeutic strategies targeting disease progression. This review examines emerging pharmacological and regenerative approaches, including disease-modifying osteoarthritis drugs (DMOADs), biologics, and cell-based therapies. Cutting-edge technologies such as RNA interference, CRISPR/Cas9, and advanced regenerative medicine are also explored for their potential to revolutionize OA management. Additionally, the integration of novel therapies with traditional interventions is discussed, highlighting opportunities for a more personalized, multimodal approach to OA care. Despite significant progress, challenges such as translational hurdles, cost barriers, and long-term efficacy require further investigation. This review emphasizes the transformative potential of emerging therapies in addressing the unmet needs of OA patients and shaping future treatment paradigms. https://apcz.umk.pl/QS/article/view/58169cartilage regenerationosteoarthritisdisease-modyfing osteoarthritis drugsemerging therapiespain managementcell-based therapies |
| spellingShingle | Piotr Robert Bakuła Kamila Jałocha Joanna Zygadło Exploring Novel Non-Operative Treatments for Osteoarthritis: An Examination of Innovative Therapies Quality in Sport cartilage regeneration osteoarthritis disease-modyfing osteoarthritis drugs emerging therapies pain management cell-based therapies |
| title | Exploring Novel Non-Operative Treatments for Osteoarthritis: An Examination of Innovative Therapies |
| title_full | Exploring Novel Non-Operative Treatments for Osteoarthritis: An Examination of Innovative Therapies |
| title_fullStr | Exploring Novel Non-Operative Treatments for Osteoarthritis: An Examination of Innovative Therapies |
| title_full_unstemmed | Exploring Novel Non-Operative Treatments for Osteoarthritis: An Examination of Innovative Therapies |
| title_short | Exploring Novel Non-Operative Treatments for Osteoarthritis: An Examination of Innovative Therapies |
| title_sort | exploring novel non operative treatments for osteoarthritis an examination of innovative therapies |
| topic | cartilage regeneration osteoarthritis disease-modyfing osteoarthritis drugs emerging therapies pain management cell-based therapies |
| url | https://apcz.umk.pl/QS/article/view/58169 |
| work_keys_str_mv | AT piotrrobertbakuła exploringnovelnonoperativetreatmentsforosteoarthritisanexaminationofinnovativetherapies AT kamilajałocha exploringnovelnonoperativetreatmentsforosteoarthritisanexaminationofinnovativetherapies AT joannazygadło exploringnovelnonoperativetreatmentsforosteoarthritisanexaminationofinnovativetherapies |