Advances in small extracellular vesicles: roles in the tumor microenvironment and epithelial ovarian cancer diagnosis and treatment
Epithelial ovarian cancer (EOC), one of the most prevalent subtypes of ovarian cancer, has a 5-year survival rate of less than 30%, highlighting the urgent need for novel diagnostic and therapeutic strategies. The tumor microenvironment (TME), a critical regulator of tumor progression, includes vari...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1526944/full |
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| author | Liang Peng Yi Lai Baodi Cao |
| author_facet | Liang Peng Yi Lai Baodi Cao |
| author_sort | Liang Peng |
| collection | DOAJ |
| description | Epithelial ovarian cancer (EOC), one of the most prevalent subtypes of ovarian cancer, has a 5-year survival rate of less than 30%, highlighting the urgent need for novel diagnostic and therapeutic strategies. The tumor microenvironment (TME), a critical regulator of tumor progression, includes various components, among which small extracellular vesicles (sEVs) serve as important molecular carriers, having gained attention as significant contributors to cancer biology. These vesicles, released by cells into the extracellular space, are pivotal in the pathogenesis of EOC. In addition, sEVs show significant promise as biomarkers and therapeutic agents for the treatment and management of this malignancy. This review explores recent advancements in the understanding of sEVs within the TME and their potential applications in the diagnosis and treatment of EOC. |
| format | Article |
| id | doaj-art-fb3208dbf1d549ea90d6021f6130b50d |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-fb3208dbf1d549ea90d6021f6130b50d2025-02-11T05:10:22ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-02-011510.3389/fonc.2025.15269441526944Advances in small extracellular vesicles: roles in the tumor microenvironment and epithelial ovarian cancer diagnosis and treatmentLiang Peng0Yi Lai1Baodi Cao2Department of Gynecology, The Second People’s Hospital of Jingdezhen, Jingdezhen, Jiangxi, ChinaDepartment of Laboratory Medicine, Yiwu Hospital Affiliated to Hangzhou Medical College, Yiwu, Zhejiang, ChinaDepartment of Gynecology, The Second People’s Hospital of Jingdezhen, Jingdezhen, Jiangxi, ChinaEpithelial ovarian cancer (EOC), one of the most prevalent subtypes of ovarian cancer, has a 5-year survival rate of less than 30%, highlighting the urgent need for novel diagnostic and therapeutic strategies. The tumor microenvironment (TME), a critical regulator of tumor progression, includes various components, among which small extracellular vesicles (sEVs) serve as important molecular carriers, having gained attention as significant contributors to cancer biology. These vesicles, released by cells into the extracellular space, are pivotal in the pathogenesis of EOC. In addition, sEVs show significant promise as biomarkers and therapeutic agents for the treatment and management of this malignancy. This review explores recent advancements in the understanding of sEVs within the TME and their potential applications in the diagnosis and treatment of EOC.https://www.frontiersin.org/articles/10.3389/fonc.2025.1526944/fullsmall extracellular vesiclesepithelial ovarian cancertumor microenvironmentdiagnostic biomarkerstherapeutic strategiesrecent advances |
| spellingShingle | Liang Peng Yi Lai Baodi Cao Advances in small extracellular vesicles: roles in the tumor microenvironment and epithelial ovarian cancer diagnosis and treatment Frontiers in Oncology small extracellular vesicles epithelial ovarian cancer tumor microenvironment diagnostic biomarkers therapeutic strategies recent advances |
| title | Advances in small extracellular vesicles: roles in the tumor microenvironment and epithelial ovarian cancer diagnosis and treatment |
| title_full | Advances in small extracellular vesicles: roles in the tumor microenvironment and epithelial ovarian cancer diagnosis and treatment |
| title_fullStr | Advances in small extracellular vesicles: roles in the tumor microenvironment and epithelial ovarian cancer diagnosis and treatment |
| title_full_unstemmed | Advances in small extracellular vesicles: roles in the tumor microenvironment and epithelial ovarian cancer diagnosis and treatment |
| title_short | Advances in small extracellular vesicles: roles in the tumor microenvironment and epithelial ovarian cancer diagnosis and treatment |
| title_sort | advances in small extracellular vesicles roles in the tumor microenvironment and epithelial ovarian cancer diagnosis and treatment |
| topic | small extracellular vesicles epithelial ovarian cancer tumor microenvironment diagnostic biomarkers therapeutic strategies recent advances |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1526944/full |
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