Resolved Hepatitis B: Achieved or Imaginary Wellbeing?
Aim. Assessment of the clinical impact of previous hepatitis B infection (PHB).Key points. PHB is characterized by the presence of viral DNA in the organism (including intrahepatic cccDNA and integrated DNA). Possible virus persistence in the PHB patient's hepatocytes potentiates the agent tran...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2021-04-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/514 |
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| _version_ | 1823860171320852480 |
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| author | S. N. Batskikh |
| author_facet | S. N. Batskikh |
| author_sort | S. N. Batskikh |
| collection | DOAJ |
| description | Aim. Assessment of the clinical impact of previous hepatitis B infection (PHB).Key points. PHB is characterized by the presence of viral DNA in the organism (including intrahepatic cccDNA and integrated DNA). Possible virus persistence in the PHB patient's hepatocytes potentiates the agent transmission risk via haemotransfusion, organ transplantation and haemodialysis. Occult HBV infection in PHB individuals can reactivate at background immunosuppressive or chemotherapies. PHB with chronic liver diseases of various aetiology significantly rises the risk of cirrhosis and hepatic cancer. The PHB association with autoimmune liver diseases and extrahepatic gastrointestinal cancer needs a careful research to confirm the possible involvement of hepatitis B virus in morbid genesis.Conclusion. No clinical signs of acute or chronic disease, HBsAg clearance and negative viral DNA load in blood of PHB individuals do not necessarily imply a complete disease eradication.PHB elicitation improves accuracy of the overall prognosis, reduces the virus transmission risk and prevents the reactivation of HBV infection. |
| format | Article |
| id | doaj-art-fb953b390c3b49b8ba678a07a93e2a79 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2021-04-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-fb953b390c3b49b8ba678a07a93e2a792025-02-10T16:14:36ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732021-04-0131171910.22416/1382-4376-2021-31-1-7-19408Resolved Hepatitis B: Achieved or Imaginary Wellbeing?S. N. Batskikh0Loginov Moscow Clinical Scientific CenterAim. Assessment of the clinical impact of previous hepatitis B infection (PHB).Key points. PHB is characterized by the presence of viral DNA in the organism (including intrahepatic cccDNA and integrated DNA). Possible virus persistence in the PHB patient's hepatocytes potentiates the agent transmission risk via haemotransfusion, organ transplantation and haemodialysis. Occult HBV infection in PHB individuals can reactivate at background immunosuppressive or chemotherapies. PHB with chronic liver diseases of various aetiology significantly rises the risk of cirrhosis and hepatic cancer. The PHB association with autoimmune liver diseases and extrahepatic gastrointestinal cancer needs a careful research to confirm the possible involvement of hepatitis B virus in morbid genesis.Conclusion. No clinical signs of acute or chronic disease, HBsAg clearance and negative viral DNA load in blood of PHB individuals do not necessarily imply a complete disease eradication.PHB elicitation improves accuracy of the overall prognosis, reduces the virus transmission risk and prevents the reactivation of HBV infection.https://www.gastro-j.ru/jour/article/view/514previous hepatitis bresolved hepatitis boccult hbv infectionanti-hbcreactivationcirrhosishepatocellular carcinoma |
| spellingShingle | S. N. Batskikh Resolved Hepatitis B: Achieved or Imaginary Wellbeing? Российский журнал гастроэнтерологии, гепатологии, колопроктологии previous hepatitis b resolved hepatitis b occult hbv infection anti-hbc reactivation cirrhosis hepatocellular carcinoma |
| title | Resolved Hepatitis B: Achieved or Imaginary Wellbeing? |
| title_full | Resolved Hepatitis B: Achieved or Imaginary Wellbeing? |
| title_fullStr | Resolved Hepatitis B: Achieved or Imaginary Wellbeing? |
| title_full_unstemmed | Resolved Hepatitis B: Achieved or Imaginary Wellbeing? |
| title_short | Resolved Hepatitis B: Achieved or Imaginary Wellbeing? |
| title_sort | resolved hepatitis b achieved or imaginary wellbeing |
| topic | previous hepatitis b resolved hepatitis b occult hbv infection anti-hbc reactivation cirrhosis hepatocellular carcinoma |
| url | https://www.gastro-j.ru/jour/article/view/514 |
| work_keys_str_mv | AT snbatskikh resolvedhepatitisbachievedorimaginarywellbeing |