A human pathogenic hantavirus circulates and is shed in taxonomically diverse rodent reservoirs.
<h4>Background</h4>Orthohantaviruses are negative-sense RNA viruses that can cause hantavirus cardiopulmonary syndrome (HCPS) in humans. In the United States, Sin Nombre orthohantavirus (SNV) is the primary cause of HCPS, with a fatality rate of 36% and most cases occuring in the southwe...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2025-01-01
|
| Series: | PLoS Pathogens |
| Online Access: | https://doi.org/10.1371/journal.ppat.1012849 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1825206839052075008 |
|---|---|
| author | Samuel M Goodfellow Robert A Nofchissey Chunyan Ye Jaecy K Banther-McConnell Thanchira Suriyamongkol Joseph A Cook Jonathan L Dunnum Ivana Mali Steven B Bradfute |
| author_facet | Samuel M Goodfellow Robert A Nofchissey Chunyan Ye Jaecy K Banther-McConnell Thanchira Suriyamongkol Joseph A Cook Jonathan L Dunnum Ivana Mali Steven B Bradfute |
| author_sort | Samuel M Goodfellow |
| collection | DOAJ |
| description | <h4>Background</h4>Orthohantaviruses are negative-sense RNA viruses that can cause hantavirus cardiopulmonary syndrome (HCPS) in humans. In the United States, Sin Nombre orthohantavirus (SNV) is the primary cause of HCPS, with a fatality rate of 36% and most cases occuring in the southwestern states. The western deer mouse, Peromyscus sonoriensis, is the primary reservoir for SNV; however, it remains unclear if alternative reservoirs exist.<h4>Results</h4>We conducted an extensive survey of SNV genetic prevalence in wild-caught small mammal communities throughout New Mexico and observed that 27% of all animals were positive for SNV. Through longitudinal trapping at a site of patient exposure, we found that SNV circulates at a high rate in multiple species over time. Furthermore, we isolated live SNV from tissues and feces from multiple small mammal species, demonstrating infectious virus in alternative and novel reservoirs.<h4>Significance</h4>Altogether, this work shows that SNV is widely prevalent and persistent throughout New Mexico in multiple small mammal reservoirs that can harbor and shed infectious virus. This encourages future work for additional surviellance efforts and revaluates host-species dynamics for New World hantaviruses. |
| format | Article |
| id | doaj-art-fc0f8f1eac864c0d8115d3ab92c8abaa |
| institution | Kabale University |
| issn | 1553-7366 1553-7374 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj-art-fc0f8f1eac864c0d8115d3ab92c8abaa2025-02-07T05:30:31ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742025-01-01211e101284910.1371/journal.ppat.1012849A human pathogenic hantavirus circulates and is shed in taxonomically diverse rodent reservoirs.Samuel M GoodfellowRobert A NofchisseyChunyan YeJaecy K Banther-McConnellThanchira SuriyamongkolJoseph A CookJonathan L DunnumIvana MaliSteven B Bradfute<h4>Background</h4>Orthohantaviruses are negative-sense RNA viruses that can cause hantavirus cardiopulmonary syndrome (HCPS) in humans. In the United States, Sin Nombre orthohantavirus (SNV) is the primary cause of HCPS, with a fatality rate of 36% and most cases occuring in the southwestern states. The western deer mouse, Peromyscus sonoriensis, is the primary reservoir for SNV; however, it remains unclear if alternative reservoirs exist.<h4>Results</h4>We conducted an extensive survey of SNV genetic prevalence in wild-caught small mammal communities throughout New Mexico and observed that 27% of all animals were positive for SNV. Through longitudinal trapping at a site of patient exposure, we found that SNV circulates at a high rate in multiple species over time. Furthermore, we isolated live SNV from tissues and feces from multiple small mammal species, demonstrating infectious virus in alternative and novel reservoirs.<h4>Significance</h4>Altogether, this work shows that SNV is widely prevalent and persistent throughout New Mexico in multiple small mammal reservoirs that can harbor and shed infectious virus. This encourages future work for additional surviellance efforts and revaluates host-species dynamics for New World hantaviruses.https://doi.org/10.1371/journal.ppat.1012849 |
| spellingShingle | Samuel M Goodfellow Robert A Nofchissey Chunyan Ye Jaecy K Banther-McConnell Thanchira Suriyamongkol Joseph A Cook Jonathan L Dunnum Ivana Mali Steven B Bradfute A human pathogenic hantavirus circulates and is shed in taxonomically diverse rodent reservoirs. PLoS Pathogens |
| title | A human pathogenic hantavirus circulates and is shed in taxonomically diverse rodent reservoirs. |
| title_full | A human pathogenic hantavirus circulates and is shed in taxonomically diverse rodent reservoirs. |
| title_fullStr | A human pathogenic hantavirus circulates and is shed in taxonomically diverse rodent reservoirs. |
| title_full_unstemmed | A human pathogenic hantavirus circulates and is shed in taxonomically diverse rodent reservoirs. |
| title_short | A human pathogenic hantavirus circulates and is shed in taxonomically diverse rodent reservoirs. |
| title_sort | human pathogenic hantavirus circulates and is shed in taxonomically diverse rodent reservoirs |
| url | https://doi.org/10.1371/journal.ppat.1012849 |
| work_keys_str_mv | AT samuelmgoodfellow ahumanpathogenichantaviruscirculatesandisshedintaxonomicallydiverserodentreservoirs AT robertanofchissey ahumanpathogenichantaviruscirculatesandisshedintaxonomicallydiverserodentreservoirs AT chunyanye ahumanpathogenichantaviruscirculatesandisshedintaxonomicallydiverserodentreservoirs AT jaecykbanthermcconnell ahumanpathogenichantaviruscirculatesandisshedintaxonomicallydiverserodentreservoirs AT thanchirasuriyamongkol ahumanpathogenichantaviruscirculatesandisshedintaxonomicallydiverserodentreservoirs AT josephacook ahumanpathogenichantaviruscirculatesandisshedintaxonomicallydiverserodentreservoirs AT jonathanldunnum ahumanpathogenichantaviruscirculatesandisshedintaxonomicallydiverserodentreservoirs AT ivanamali ahumanpathogenichantaviruscirculatesandisshedintaxonomicallydiverserodentreservoirs AT stevenbbradfute ahumanpathogenichantaviruscirculatesandisshedintaxonomicallydiverserodentreservoirs AT samuelmgoodfellow humanpathogenichantaviruscirculatesandisshedintaxonomicallydiverserodentreservoirs AT robertanofchissey humanpathogenichantaviruscirculatesandisshedintaxonomicallydiverserodentreservoirs AT chunyanye humanpathogenichantaviruscirculatesandisshedintaxonomicallydiverserodentreservoirs AT jaecykbanthermcconnell humanpathogenichantaviruscirculatesandisshedintaxonomicallydiverserodentreservoirs AT thanchirasuriyamongkol humanpathogenichantaviruscirculatesandisshedintaxonomicallydiverserodentreservoirs AT josephacook humanpathogenichantaviruscirculatesandisshedintaxonomicallydiverserodentreservoirs AT jonathanldunnum humanpathogenichantaviruscirculatesandisshedintaxonomicallydiverserodentreservoirs AT ivanamali humanpathogenichantaviruscirculatesandisshedintaxonomicallydiverserodentreservoirs AT stevenbbradfute humanpathogenichantaviruscirculatesandisshedintaxonomicallydiverserodentreservoirs |