The perspectives of autologous hepatocytes generation for the treatment of liver failure

The aim of the review. To analyze the main cellbased sources of hepatocyte for artificial liver generation, to describe the key features of each approach, to discuss benefits and shortcomings.Summary. Artificial liver transplantation could be an alternative for traditional transplantation. For the a...

Full description

Saved in:
Bibliographic Details
Main Authors: M. N. Evseeva, A. F. Sheptulina, Yu. P. Rubtsov
Format: Article
Language:Russian
Published: Gastro LLC 2015-12-01
Series:Российский журнал гастроэнтерологии, гепатологии, колопроктологии
Subjects:
Online Access:https://www.gastro-j.ru/jour/article/view/1038
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of the review. To analyze the main cellbased sources of hepatocyte for artificial liver generation, to describe the key features of each approach, to discuss benefits and shortcomings.Summary. Artificial liver transplantation could be an alternative for traditional transplantation. For the artificial liver generation specialized cells are required. So far several sources of hepatocyte-like cells generation are known. This review presents alternative approaches for liver failure treatment: inhibition of epithelial-mesenchymal transformation, e.g. by induction of proliferation (gene therapy with HGF), and by influence on immune imbalance (T-regulatory lymphocytes application).Conclusion. Evaluation of the main sources of autologous hepatocytes would provide insights into priority directions of future studies, and lead to progress in liver failure treatment.
ISSN:1382-4376
2658-6673