The perspectives of autologous hepatocytes generation for the treatment of liver failure
The aim of the review. To analyze the main cellbased sources of hepatocyte for artificial liver generation, to describe the key features of each approach, to discuss benefits and shortcomings.Summary. Artificial liver transplantation could be an alternative for traditional transplantation. For the a...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Gastro LLC
2015-12-01
|
| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| Subjects: | |
| Online Access: | https://www.gastro-j.ru/jour/article/view/1038 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823860171822071808 |
|---|---|
| author | M. N. Evseeva A. F. Sheptulina Yu. P. Rubtsov |
| author_facet | M. N. Evseeva A. F. Sheptulina Yu. P. Rubtsov |
| author_sort | M. N. Evseeva |
| collection | DOAJ |
| description | The aim of the review. To analyze the main cellbased sources of hepatocyte for artificial liver generation, to describe the key features of each approach, to discuss benefits and shortcomings.Summary. Artificial liver transplantation could be an alternative for traditional transplantation. For the artificial liver generation specialized cells are required. So far several sources of hepatocyte-like cells generation are known. This review presents alternative approaches for liver failure treatment: inhibition of epithelial-mesenchymal transformation, e.g. by induction of proliferation (gene therapy with HGF), and by influence on immune imbalance (T-regulatory lymphocytes application).Conclusion. Evaluation of the main sources of autologous hepatocytes would provide insights into priority directions of future studies, and lead to progress in liver failure treatment. |
| format | Article |
| id | doaj-art-fc542e0550cd4d4298b57b88ad3e241c |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2015-12-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-fc542e0550cd4d4298b57b88ad3e241c2025-02-10T16:14:34ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732015-12-012564957645The perspectives of autologous hepatocytes generation for the treatment of liver failureM. N. Evseeva0A. F. Sheptulina1Yu. P. Rubtsov2Lomonosov Moscow State UniversityState educational government-financed institution of higher professional education «Sechenov First Moscow state medical university», Ministry of Healthcare of the Russian FederationLomonosov Moscow State UniversityThe aim of the review. To analyze the main cellbased sources of hepatocyte for artificial liver generation, to describe the key features of each approach, to discuss benefits and shortcomings.Summary. Artificial liver transplantation could be an alternative for traditional transplantation. For the artificial liver generation specialized cells are required. So far several sources of hepatocyte-like cells generation are known. This review presents alternative approaches for liver failure treatment: inhibition of epithelial-mesenchymal transformation, e.g. by induction of proliferation (gene therapy with HGF), and by influence on immune imbalance (T-regulatory lymphocytes application).Conclusion. Evaluation of the main sources of autologous hepatocytes would provide insights into priority directions of future studies, and lead to progress in liver failure treatment.https://www.gastro-j.ru/jour/article/view/1038liver failureliver fibrosisautologous hepatocytesinduced pluripotent cellsmesenchymal stromal cells |
| spellingShingle | M. N. Evseeva A. F. Sheptulina Yu. P. Rubtsov The perspectives of autologous hepatocytes generation for the treatment of liver failure Российский журнал гастроэнтерологии, гепатологии, колопроктологии liver failure liver fibrosis autologous hepatocytes induced pluripotent cells mesenchymal stromal cells |
| title | The perspectives of autologous hepatocytes generation for the treatment of liver failure |
| title_full | The perspectives of autologous hepatocytes generation for the treatment of liver failure |
| title_fullStr | The perspectives of autologous hepatocytes generation for the treatment of liver failure |
| title_full_unstemmed | The perspectives of autologous hepatocytes generation for the treatment of liver failure |
| title_short | The perspectives of autologous hepatocytes generation for the treatment of liver failure |
| title_sort | perspectives of autologous hepatocytes generation for the treatment of liver failure |
| topic | liver failure liver fibrosis autologous hepatocytes induced pluripotent cells mesenchymal stromal cells |
| url | https://www.gastro-j.ru/jour/article/view/1038 |
| work_keys_str_mv | AT mnevseeva theperspectivesofautologoushepatocytesgenerationforthetreatmentofliverfailure AT afsheptulina theperspectivesofautologoushepatocytesgenerationforthetreatmentofliverfailure AT yuprubtsov theperspectivesofautologoushepatocytesgenerationforthetreatmentofliverfailure AT mnevseeva perspectivesofautologoushepatocytesgenerationforthetreatmentofliverfailure AT afsheptulina perspectivesofautologoushepatocytesgenerationforthetreatmentofliverfailure AT yuprubtsov perspectivesofautologoushepatocytesgenerationforthetreatmentofliverfailure |